近六年《江西图书馆学刊》载文、引文及作者分析

以《江西图书馆学刊》1998～2003年载、引、被引及作情况为研究对象，分析了载的数量、栏目和所占页数，引的数量、来源、语种和年代，载被引情况以及作的单位分布和作数量，从而反映出该刊近六年的栽情况及学术影响。     

澳大利亚公共图书馆活动管窥

本文主要从资源、设施、手段以及与社会互动等方面对澳大利亚公共图书馆的服务特色进行了描绘与分析。认为在我国的图书馆事业发展中，设施建设和环境改善必须与观念更新及人员素质的提高同步，才能切实提高服务质量，最终实现“以人为本”的目标。     

社区图书馆信息服务新思维

社区图书馆的信息服务与一般公共图书馆相比较既有区别也有共同之处。本文通过对社区图书馆信息服务的特殊性及其发展趋势的探讨，提出了社区图书馆开展信息服务新思维。     

致力于优雅社会的新加坡公共图书馆

文章介绍了新加坡公共图书馆的体系、新馆建设以及近年来管理与服务的创新。     

上海图书馆藏四册抄本《松隐文集》卷十四辨伪——兼考《全宋诗》曹勋卷重出诗歌之归属

上海图书馆藏四册抄本《松隐文集》为弥补原第十四卷散佚的缺憾,从《宋诗抄》中抄录杨万里、许月卿、方岳、林景熙、文天祥、郑震的诗歌共28首,拼凑成第十四卷,其为伪作无疑。《全宋诗》所收录的该卷诗歌当剔除。同时上海图书馆将该书著录为明抄本,当改为清抄本。     

基于文件连续体理论模型的“第五维度理论”

从文件生命周期理论到文件连续体理论,档案界对文件运动形式的理解从线性向多维转变。在后现代主义档案观的影响和跨界合作的时代背景下,四维的文件连续体理论模型逐渐向五维演变。本文以加拿大档案学者勒梅教授及其团队提出的“第五维度理论”为基础,认为应该充分考虑利用者在档案工作流程中的作用,同时将对档案的“探索”性开发看成是对文件连续体理论模型的第五个维度。     

王阳明著述的两个版本略考

王阳明之所"立言",版本甚多,然有明隆庆谢氏刻本《王文成公全书》和明崇祯施氏刻本《阳明先生集要》乃为显本,两本各有殊同,皆为读研阳明思想学说最重要的文献资料。     

"你的套鞋带给了人间什么幸福?"——解读安徒生的《幸运的套鞋》

在《幸运的套鞋》中,安徒生利用幻想世界来做现实的人生试验,指明一劳永逸的“幸运套鞋”并不能给我们带来真正的幸福。     

钢琴组曲《南国印象》曲式结构试析

《南国印象》是一部中西合璧的钢琴组曲,它在运用西方曲式结构的同时也有不少创新。可以看出作者在创作上不拘一格,运用各种技法使作品在保持民族气质的同时又具有时代的精神。     

Effects of purposeful soccer heading on circulating small extracellular vesicle concentration and cargo

BackgroundConsidering the potential cumulative effects of repetitive head impact (HI) exposure, we need sensitive biomarkers to track short- and long-term effects. Circulating small extracellular vesicles (sEVs) (<200 nm) traffic biological molecules throughout the body and may have diagnostic value as biomarkers for disease. The purpose of this study was to identify the microRNA (miRNA) profile in circulating sEVs derived from human plasma following repetitive HI exposure.MethodsHealthy adult (aged 18–35 years) soccer players were randomly assigned to one of 3 groups: the HI group performed 10 standing headers, the leg impact group performed 10 soccer ball trapping maneuvers over 10 min, and the control group did not participate in any soccer drills. Plasma was collected before testing and 24 h afterward, and sEVs were isolated and characterized via nanoparticle tracking analysis. Next-generation sequencing was utilized to identify candidate miRNAs isolated from sEVs, and candidate microRNAs were analyzed via quantitative polymerase chain reaction. In silico target prediction was performed using TargetScan (Version 7.0; targetscan.org) and miRWalk (http://mirwalk.umm.uni-heidelberg.de/) programs, and target validation was performed using luciferase reporter vectors with a miR-7844-5p mimic in human embryonic kidney (HEK) 293T/17 cells.ResultsPlasma sEV concentration and size were not affected across time and group following repetitive HI exposure. After 24 h, the HI read count from next-generation sequencing showed a 4-fold or greater increase in miR-92b-5p, miR-423-5p, and miR-24-3p and a 3-fold or greater decrease in miR-7844-5p, miR-144-5p, miR-221-5p, and miR-22-3p. Analysis of quantitative polymerase chain reaction revealed that leg impact did not alter the candidate miRNA levels. To our knowledge, miR-7844-5p is a previously unknown miRNA. We identified 8 miR-7844-5p mRNA targets: protein phosphatase 1 regulatory inhibitor subunit 1B (PPP1R1B), LIM and senescent cell antigen-like domains 1 (LIMS1), autophagy-related 12 (ATG12), microtubule-associated protein 1 light chain 3 beta (MAP1LC3B), integrin subunit alpha-1 (ITGA1), mitogen-activated protein kinase 1 (MAPK1), glycogen synthase kinase 3β (GSK3β), and mitogen-activated protein kinase 8 (MAPK8).ConclusionCollectively, these data indicate repetitive HI exposure alters plasma sEV miRNA content, but not sEV size or number. Furthermore, for the first time we demonstrate that previously unknown miR-7844-5p targets mRNAs known to be involved in mitochondrial apoptosis, autophagy regulation, mood disorders, and neurodegenerative disease.