Effect of felodipine on the serum lipid profile of patients with hypertension

Forty patients suffering from mild to moderate degree of hypertension were put on felodipine. Their lipid profile was analysed before the start of their therapy and consecutively at two and four months after starting felodipine. There was a statistically significant fall in the levels of serum cholesterol, serum triglycerides and serum total lipids; though no appreciable variation was observed in HDL and LDL cholesterol levels. At baseline there were a few patients who had higher than the normal range of the serum lipid profile. Analysis of these patients showed a highly significant fall in the levels of serum cholesterol, serum triglycerides, serum LDL-cholesterol and serum total lipids i.e. felodipine modified the lipid profiles of hypertensive patients in a positive way.     

密度泛函理论研究1,1’-二吡咯的结构和振动光谱

采用密度泛函理论的B3LYP方法研究了1,1’-二吡咯的结构和振动光谱.通过对分子势能面扫描确定了当两个吡咯环在相互垂直的两个平面上时具有最低的能量,比平面构型分子的能量低33.09 kJ/mol,是势能面上的稳定构型,这与实验结果一致.同时,对优化所得的稳定构型在相同水平上分析了1,1’-二吡咯的振动光谱,并对光谱进行了指认.     

水膨体类调剖剂堵调机理实验研究

目前,我国大多数注水开发的油田已进入高含水开发阶段,堵水调剖技术得到了广泛应用。本文论述了通过物模试验,开展水膨体类调剖剂对孔隙的封堵能力、封堵强度等研究,探索水膨体类调剖剂在地层中的封堵机理,对高含水油田合理应用水膨体类调剖剂提供参考。     

青海湖北沙柳河镇土壤水与土壤水库研究

根据土壤含水量和粒度测定,对青海湖北侧沙柳河镇附近土壤含水量与土壤水库进行了研究。结果表明：青海湖北侧土壤含水量随着深度的增加而减少,在0.6m深度以下土壤含水量严重不足;该区土壤水库蓄水性非常特殊,上部蓄水量多,下部蓄水量少。该区土壤厚度小,土壤水库容量小,蓄水能力小,干旱年易于发生草原退化。沙柳河镇土壤水集中分布在土壤的上部,初步认为这是该区土层冻结期较长和低温导致蒸发作用较弱决定的,这对该区根系较浅的草原植被的生长发育是非常有利的。在近年降水增多条件下,该区土壤水分能够满足草原植被的生长。该区不适于发展乔灌木植被,适合发展根系短、耗水较少的草原植被。     

Using profile expansion techniques to alleviate the new user problem

Collaborative Filtering techniques have become very popular in the last years as an effective method to provide personalized recommendations. They generally obtain much better accuracy than other techniques such as content-based filtering, because they are based on the opinions of users with tastes or interests similar to the user they are recommending to. However, this is precisely the reason of one of its main limitations: the cold-start problem. That is, how to recommend new items, not yet rated, or how to offer good recommendations to users they have not information about. For example, because they have recently joined the system. In fact, the new user problem is particularly serious, because an unsatisfied user may stop using the system before it could even collect enough information to generate good recommendations. In this article we tackle this problem with a novel approach called “profile expansion”, based on the query expansion techniques used in Information Retrieval. In particular, we propose and evaluate three kinds of techniques: item-global, item-local and user-local. The experiments we have performed show that both item-global and user-local offer outstanding improvements in precision, up to 100%. Moreover, the improvements are statistically significant and consistent among different movie recommendation datasets and several training conditions.     

体育运动心理学中心境量表及其应用研究

通过查阅和分析文献资料，对心境量表的有关研究进行了综述，特别对在体育运动心理学中的应用研究，从三个方面进行了阐述，提出了当前研究中存在的问题。     

Association of Type II 5′ Monodeiodinase Thr92Ala Single Nucleotide Gene Polymorphism and Circulating Thyroid Hormones Among Type 2 Diabetes Mellitus Patients

Diabetes mellitus and thyroid disorders are common endocrinopathies, which often occur parallel. Dyslipidemia is very common in both of these conditions. The development of hypothyroidism is well-known in type 1 diabetics, but it was not distinctly understood in type 2 diabetics. Thus we tried to examine the association between type II deiodinase (D2 or DIO2) Thr92Ala single nucleotide gene polymorphism and thyroid function among type 2 diabetes mellitus patients. A total of 130 type 2 diabetics were screened and genotyped for DIO2 Thr92Ala polymorphism. Fasting plasma glucose, Glycosylated haemoglobin, lipid and thyroid profiles, malondialdehyde (MDA) and paraoxonase were estimated according to standard procedures. A significant altered level of thyroid hormones (TH’s) was found in Ala/Ala genotype when compared with Thr/Thr or Thr/Ala genotype. DIO2 and T₃:T₄ ratio significantly decreased, whereas total T₄ and thyroid stimulating hormone levels significantly elevated among Ala/Ala genotype (131 ± 30 ng/ml; 0.12 ± 0.05; 7.17 ± 2.05 µg/dl; 4.77 ± 3.1 µIU/ml, respectively) when compared with Thr/Thr + Thr/Ala genotypes (176 ± 33 ng/ml; 0.21 ± 0.05; 5.21 ± 1.1 µg/dl; 2.59 ± 1.61 µIU/ml respectively). Moreover, D2 levels were significantly negatively correlated with TH’s levels except total T₄ among Ala/Ala genotypes. All the patients were having a poor glycemic control, and their glycemic status was positively correlating with MDA levels. On the other hand, serum paraoxonase activity decreased among Ala/Ala genotype (104 ± 21 vs. 118 ± 18 nmol/min/ml). In conclusion, DIO2 Ala92 homozygous variant found to be associated with altered levels of DIO2, Thyroid profile and paraoxonase. Hence, we recommend to do detail study of genetic factors related to thyroid function and prevent additional diabetic complications.     

塔里木河下游应急输水前后胡杨生长量分析——以喀尔达依断面为例

通过对塔里木河下游喀尔达依断面应急输水前后不同离河距离胡杨生长量观测与统计分析，结果表明：应急输水前(1994年～1999年，下同)不同离河距离胡杨生长曲线均呈现平行、重合与水平状态，即输水前不同离河距离每年生长量大小趋于一致；应急输水后(2000年～2004年，下同)不同离河距离生长量曲线不平行、不重合、不水平，即不同离河距离胡杨生长量不一致。结合喀尔达依断面应急输水前地下水埋深值及6次应急输水资料，对胡杨生长量进行对应分析，结果表明：应急输水前，不同离河距离地下水埋深的一致性决定了胡杨生长量基本相同，当地下水埋深在9m时，胡杨一级枝年轮仍具有有限的生长量；应急输水后，随输水总量增加及地下水埋深抬升，胡杨生长量同步增加，应急输水明显地促进了河畔带胡杨的生长与恢复；应急输水后胡杨生长量大于应急输水前，对输水产生积极响应，可作为判定胡杨恢复效果的定量指标之一。     

Impact of iodine deficiency on thyroid function in pregnant African women — A possible factor in the genesis of ‘small for dates’ babies

The effect of iodine deficiency (ID) on thyroid function in African women during pregnancy and postnatal period was examined, for which very limited information is available. Serum T₄, T₃, TSH, TBG, thyroxine binding capacity (TBK), free thyroxine index (FT₄I=T₄/TBK) and T₄/TBG were determined by ELISA technique in 32 pregnant women (resident of Plateau state, Nigeria- an ID zone) through pregnancy upto term delivery, and in 5 women up to 6 weeks post delivery. Urinary iodide level was measured at delivery to determine the degree of iodine deficiency. Results were matched with a non pregnant control comprising 44 subjects. 5555 birth weights (BW) of term babies in the region were analysed to determine the prevalence of ‘small for dates’ (SFD) babies in the population. Results show that the level of serum FT₄I was elevated very significantly at late gestation (P<.001) but the women were not hyperthyroid, suggesting a marked disturbance in binding of T₄ with TBG during pregnancy. Five women with SFD babies were found in ‘compensated hypothyroid state’ and showed a significant depression (p<.01) in serum T₄/TBG, T₄, FT₄I and T₃ levels to a low normal range, with a concurrent significant rise (p.<.001) in TSH level (above normal range) throughout pregnancy. Incidence of SFD babies was higher (p.<.001) in ID zone (Bassa 15.2%) compared to control zone (Jos 9.8%). It is concluded that a state of maternal ‘subclinical (compensated) hypothyroidism’ during pregnancy possibly plays an important role in the aetiopathogenesis of SFD babies in Africans. A normal reference range for thyroid parameters at various stages of pregnancy in healthy African women is established for the first time.     

从顺应论看奥康集团简介英译策略

对奥康集团英文简介进行分析后发现,最主要的是缺乏英译策略。为提高企业简介英译本的质量,从顺应论的语境顺应角度提出省译法顺应社交世界、概括法顺应物理世界、整合法顺应语言结构的英译策略。