音频DCT系数分布函数的建模

针对DCT系数的非高斯性以及广义高斯分布和α稳定分布在音频DCT系数建模上的局限性,提出了一种混合模型.该模型由广义高斯分布和α稳定分布线性加权而成,其加权系数由遗传算法产生.模型的准确性由衡量2个概率分布之间差异的物理量Kullback-Leibler Divergence(KL散度)测量.实验结果表明,提出的混合模型接近于真实分布,并可用于音频检索和隐写分析.     

黄参多糖对小鼠血清CK、LDH和MG、HG及运动耐力影响的研究

应用从黄参肉质根中提取出的黄参多糖（SGP）灌喂小鼠实验,结果显示SGP可明显增加MG、HG的含量,为运动提供快速的能源供应。还显示单纯运动的小鼠CK、LDH活性显著高于对照,而灌服SGP各组比单纯运动组都有所下降,并明显存在量效关系,其中以150mg.kg^-1剂量组效果最佳。实验为应用黄参多糖SGP作为运动营养补剂提供了理论依据。     

基于对数变换的非高斯噪声几何功率谱特性分析

在简要介绍稳定分布统计特性的基础上,介绍了常用的信号非线性变换方法,建立不同于传统二阶过程的对数阶过程及其几何功率、几何相关、几何功率谱密度等新的信号分析概念,提出了一种新的稳定分布对数阶白噪声概念及其判断准则,建立了一种基于非线性变换的重拖尾稳定分布脉冲信号分析的新框架与模型。计算机模拟表明,这种模型是一种在高斯和分数低阶α稳定分布噪声条件下具有良好韧性的模型,是对传统的基于二阶统计量基础上的信号模型分析方法的改造与推广。     

乳酸脱氢酶及其同工酶在游泳选材中的应用

乳酸脱氢酶（LDH）同工酶含量的差异影响运动员机体的有氧和无氧代谢能力，而LDH同工酶的合成受遗传基因调控，为此我们对青少年游泳运动员进行了LDH同工酶谱的调查，结果是长距离游泳项目运动员血清LDH1和LDH2百分含量相对较高，中距离项目运动员LDH4和LDH5百分含量相对较高。LDH同工酶百分含量可作为中距离和长距离游泳运动员的选材指标之一。     

Serum Lactate Dehydrogenase in Non-Hodgkin’s Lymphoma: A Prognostic Indicator

Non-Hodgkin’s lymphoma constitutes a group of disorders originating from the malignant transformation of lymphocytes and involving either the lymph nodes or extranodal sites. NHL commonly presents in the sixth to seventh decade of life with a male preponderance (50–75 %). Recent studies have shown importance of serum LDH in prognosis of NHL. Authors report a case of a 63 year old male presenting with complaints of fever and backache for past 4 months. General and systemic examination revealed bilateral axillary lymphadenopathy and splenomegaly respectively. Serum LDH level was highly elevated (3441 U/l). Excisional axillary and bone marrow biopsy were done before oncology referral. Complete workup revealed diffuse Non-Hodgkin’s lymphoma with bone marrow infiltration. Patient died because of acute renal failure due to NHL and DM 2 (Type 2 diabetes mellitus).     

高等植物中氨同化酶及其同工酶研究

介绍了高等植物中谷氨酰胺合成酶及其同工酶的分布及亚细胞定位、生理功能及其基因的研究进展 ;同时还简要介绍了谷氨酸脱氢酶、谷氨酸合酶的分布及其生理作用     

体育系和生物系女生70％VO2max恒负荷前后的血乳酸和乳酸脱氢酶的含量变化

本研究测定了 1 7例体育系女生和 1 4例生物系女生 70 % VO2 max恒负荷前后体内血乳酸 (简称 BLA)和乳酸脱氢酶 (简称 LDH)含量。结果表明 :体育系女生在恒负荷后体内的 BLA浓度明显低于生物系女生 (p<0 .0 5) :LDH在恒负荷后含量明显增高 ,但两系之间没有明显差异。在 70 % VO2 max后 BLA含量有明显差异 ,这主要是体育锻炼使机体机能改善 ,有氧代谢能力和耐乳酸能力提高 ,从而为体育系的体育训练提供有价值的参考     

Synergetic Interaction of HLA-DRB1*07 Allele and TNF-Alpha − 863 C/A Single Nucleotide Polymorphism in the Susceptibility to Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease which is characterized by dysregulation of various cytokines propagating the inflammatory processes that is responsible for tissue damage. Tumor necrosis factor alpha (TNF-α) is one of the most important immunoregulatory cytokines that has been implicated in the different autoimmune diseases including SLE. Two hundred and two patients with SLE and 318 controls were included in the study. The TNF-α gene promoter region (from − 250 to − 1000 base pairs) was analyzed by direct Sanger’s DNA sequencing method to find promoter variants associated with South Indian SLE patients. We have analyzed six TNF-α genetic polymorphisms including, − 863C/A (rs1800630), − 857C/T (rs1799724), − 806C/T (rs4248158), − 646G/A (rs4248160), − 572A/C (rs4248161) and − 308G/A (rs1800629) in both SLE patients and controls. We did not find association of TNF-α gene promoter SNPs with SLE patients. However, the − 863A (rs1800630) allele showed association with lupus nephritis phenotype in patients with SLE (OR: 1.62, 95%CI 1.04–2.53, P = 0.034). We found serum TNF-α level was significantly elevated in SLE cases as compared to control and found no association with any of the polymorphisms. The haplotype analysis revealed a significant protective association between the wild TNF-α alleles at positions − 863C, − 857C, − 806C, − 646G, − 572A and − 308G (CCCGAG) haplotype with lupus nephritis phenotype (OR 0.53, 95% CI 0.35–0.82, P = 0.004). Additionally, the TNF-α − 863 C/A (rs1800630) polymorphism and HLA-DRB1*07 haplotype showed significant differences between SLE patients and controls (OR 4.79, 95% CI 1.73–13.29, P = 0.0009). In conclusion, TNF-α − 863A allele (rs1800630) polymorphism is associated with increased risk of nephritis in South Indian SLE patients. We also found an interaction between HLA-DRB1*07 allele with TNF-α − 863 C/A promoter polymorphism giving supportive evidence for the tight linkage disequilibrium between TNF-α promoter SNPs and MHC class II DRB1 alleles.     

高住低训对大鼠骨骼肌低氧诱导因子-1α和血管内皮生长因子蛋白表达的影响

目的:探讨高住低训(HiLo)对大鼠骨骼肌中低氧诱导因子(HIF-1α)和血管内皮因子(VEGF)蛋白表达的影响。方法:40只SD大鼠随机分为常氧安静组(C)、常氧训练组(E)、低氧安静组(L)和高住低训组(H)。实验选择模拟2500m海拔低氧环境,以20m/min的速度,6次/周,40min/d进行跑台训练。采用HE染色法观察高住低训对大鼠骨骼肌形态影响,RT-PCR法检测,半定量分析大鼠腓肠肌HIF-1αmRNA和VEGF m RNA表达,Western Blot检测,Image分析大鼠腓肠肌HIF-1α和VEGF蛋白表达。结果:H组HIF-1αm RNA和VEGF m RNA表达量显著升高(P<0.05),H组HIF-1α和VEGF蛋白表达显著升高(P<0.05)。结论:高住低训诱导HIF-1αmRNA和VEGF m RNA表达,高住低训对大鼠腓肠肌起到保护作用,其机制可能是通过上调腓肠肌HIF-1α和VEGF蛋白表达。     

鬼针草总黄酮对小鼠急性肝损伤的影响

将66只昆明小鼠随机分为11组：正常组、模型组及鬼针草全草、叶和枝总黄酮治疗组,每治疗组分为低、中和高剂量（40、80、160 mg/kg）亚组,鬼针草总黄酮（TFB）采用正交试验法提取.治疗组连续灌胃14 d后以四氯化碳（CCl4）建立小鼠急性肝损伤模型,IFCC速率法检测小鼠血清中丙氨酸氨基转移酶（alanine transaminase, ALT）、天冬氨酸氨基转移酶（aspartate transaminase,AST）和乳酸脱氢酶（lactate dehydrogenase,LDH）活性.观察不同生理部位TFB对小鼠急性肝损伤时肝功能的影响,探讨其肝损伤保护作用.结果表明：与模型组相比,叶和全草TFB（40 mg/kg）和枝TFB（80 mg/kg）能极显著降低ALT含量（P＜0.01）;仅有叶TFB（40 mg/kg）能极显著降低AST含量（P＜0.01）,而枝TFB（160 mg/kg）能极显著升高AST（P＜0.01）含量;叶和全草TFB在40 mg/kg时LDH活性极显著降低（P＜0.01）.提示鬼针草不同生理部位TFB在急性肝损伤中的作用不同,仅有叶TFB在低剂量（40 mg/kg）时表现出较好的肝保护作用,其余鬼针草各组提示可能肝毒性较大.