Combination of Se-methylselenocysteine,D-α-tocopheryl succinate, β-carotene,and L-lysine can prevent cancer metastases using as an adjuvant therapy

ObjectivePrimary tumor treatment through surgical resection and adjuvant therapy has been extensively studied, but there is a lack of effective strategies and drugs for the treatment of tumor metastases. Here, we describe a functional product based on a combination of compounds, which can be used as an adjuvant therapy and has well-known mechanisms for inhibiting cancer metastases, improving anti-cancer treatment, and enhancing immunity and antioxidant capacity. Our designed combination, named MVBL, consists of four inexpensive compounds: L-selenium-methylselenocysteine (MSC), D-‍α‍-tocopheryl succinic acid (VES), β‍-carotene (β‍-Ca), and L-lysine (Lys).MethodsThe effects of MVBL on cell viability, cell cycle, cell apoptosis, cell migration, cell invasion, reactive oxygen species (ROS), and paclitaxel (PTX)-combined treatment were studied in vitro. The inhibition of tumor metastasis, antioxidation, and immune enhancement capacity of MVBL were determined in vivo.ResultsMVBL exhibited higher toxicity to tumor cells than to normal cells. It did not significantly affect the cell cycle of cancer cells, but increased their apoptosis. Wound healing, adhesion, and transwell assays showed that MVBL significantly inhibited tumor cell migration, adhesion, and invasion. MVBL sensitized MDA-MB-231 breast cancer cells to PTX, indicating that it can be used as an adjuvant to enhance the therapeutic effect of chemotherapy drugs. In mice, experimental data showed that MVBL inhibited tumor metastasis, prolonged their survival time, and enhanced their antioxidant capacity and immune function.ConclusionsThis study revealed the roles of MVBL in improving immunity and antioxidation, preventing tumor growth, and inhibiting metastasis in vitro and in vivo. MVBL may be used as an adjuvant drug in cancer therapy for improving the survival and quality of life of cancer patients.     

Hyperinsulinemia and Hypoadiponectinemia are Associated with Increased Risk for Occurrence of Ovarian Cancer in Non-diabetic Women of North Indian Population

Ovarian cancer has been emerged as a most common and lethal gynecological malignancy in India. High serum insulin and low adiponectin have been associated with increased risk of ovarian cancer. But their role in development of ovarian cancer is conflicting and little evidence is available. We aimed to evaluate blood levels of insulin and adiponectin in epithelial ovarian cancer (EOC) patients and their association with the risk to develop EOC. The study included following three groups; Group 1: fifty cases of cytohistopathologically confirmed cases of EOC, Group 2: fifty age matched cases of benign ovarian conditions and Group 3: fifty ages matched healthy controls with no evidence of any benign or malignant ovarian pathology as ruled out by clinical examination and relevant investigations. Cytohistopathologically confirmed and newly diagnosed cases of EOC and benign ovarian cancer were included in this study. The median value of fasting serum insulin was significantly high (15.0 µlU/ml, P = 0.02) and adiponectin were significantly low (5.1 µg/ml, P < 0.001) in ovarian cancer patients compared to benign ovarian tumors and healthy controls group. A significant increase risk of ovarian cancer was found in high tertile (≥ 18.7 µlU/ml) of serum insulin level (OR = 2.7; 95% CI = 1.00–6.67, P = 0.04) and lower tertile (≤ 5.45 µg/ml) of adiponectin level (OR = 3.2; 95% CI = 1.10–9.71, P = 0.03). High serum insulin level and low adiponectin levels were significantly associated with increased risk for development of ovarian cancer.     

“Tightening the Knots” of the International Drugs Trade in Brazil

Much academic analysis of media representations of drugs-related violence in Brazil has focused on their role in perpetuating violence and societal divisions. There is less research on how the country’s traditional news media can shape information in order to foster dialogue between people and potentially resolve conflict. This article aims to address this gap by exploring the possibilities and challenges for printed news media to acquire “mediated” social capital. The concept is understood here as a specific resource of power that has the potential to connect people from diverse social, cultural and economic backgrounds. In order to do so, we analyse how a popular Rio newspaper has used its symbolic power to produce social capital with an investigative series about Brazil’s involvement in the international drugs trade. It is argued here that the series paints a complex picture of its causes and consequences and is an important step towards a deliberative process about possible solutions to drugs-related violence in Rio and beyond.     

抗癌食品与防癌机理综述

癌症是人类的一大疾患,严重地威胁着人体生命,对于癌症的发病机理、成因、预防措施、诊治技术等方面的研究是目前全世界十分关注的重大课题.对抗癌食品以及抗癌的原理和方法等进行论述.     

国内有关硒与癌症发生相关文献的评价

目的:通过对国内有关硒与癌症发生的相关文献进行循证医学评价来了解目前相关文献的质量现状.方法:在生物医学文献数据库中以"硒"和"癌症"为主题词检索建库至2014年6月的相关文献,对检出的文献进行筛选后,利用九级证据评价标准及M量表对所纳入的文献进行评价.结果:九级评价标准:纳入的376篇文献中系统评价/Meta分析的文献为0篇,随机对照试验(RCT)文献33篇,其他343篇.M量表:33篇RCT文献评价结果中4分的文献有3篇,未见大于4分的文献.结论:九级评价结果:目前国内有关硒与癌症关系的研究中,动物研究和体外研究占多数,RCT研究相对较少,系统评价/Meta分析文献未见.M量表评价结果:目前国内有关硒与癌症发生相关文献的质量整体水平不高,在实验研究设计中存在很多问题,有待进一步提高.高质量证据的研究表明硒具有防癌治癌的作用,硒制剂能够增强一些化疗药物的疗效,并且减少化疗或放疗对人体产生的副作用.     

热休克蛋白(HSP70、HSP27)在食管癌组织中表达的意义

目的 :探讨HSP70和HSP2 7在食管癌组织中的表达情况。方法 :采用SP免疫组织化学染色检测 5 9例食管癌组织中HSP70和HSP2 7。结果 :HSP70和HSP2 7的总阳性率分别为 6 4.4 1% (38/5 9)和 5 8.6 2 % (34/5 8) ,HSP70和HSP2 7的共同阳性率为 30 .0 0 % (9/30 )。结论 :在食管癌中HSP70和HSP2 7普遍表达。     

抗消化性溃疡药物的研究概述

消化性溃疡是一类常见病、高发性病,严重影响着人们的生活。目前,在抗消化性溃疡药品市场上形成了质子泵抑制剂类、H2-受体拮抗剂、胃粘膜保护剂三大主体药物格局和临床用药"五足鼎立"局面,产品的更新换代又为消化性溃疡的治疗输入了新鲜血液。     

Oxidative stress and antioxidant status in cervical cancer patients

Cervical cancer (CaCx) is a global public health problem as it is the second most common cancer leading to the death of women worldwide. Many references revealed that the low levels of antioxidants induce the generation of free radicals leading to DNA damage and further mutations. In the present study attempt have been made to evaluate the levels of serum Lipid peroxide, Nitric Oxide (NO^.) Erythrocytic—Superoxide Dismutase (RBC-SOD), Vitamin-C, serum Copper (Cu) and serum Zinc (Zn). 120 patients were divided in 4 groups according to the increasing CaCx stages i.e. stage I, II, III & IV respectively. All the patients were around the age group of 25–65 years. 30 healthy women between the same age group were treated as controls. Highly significant increased values of MDA, NO^. and Cu were observed (p<0.001) whereas the activity of RBC-SOD, levels of Vitamin-C and Zn were significantly decreased in CaCx patients as compared with healthy controls (p<0.001). Cu/Zn ratio was found to be altered in CaCx patients. From our findings it can be concluded that the oxidative stress is induced among CaCx patients, which inturn increases the risk of CaCx.     

Performance-enhancing drugs as a collective action problem

Current general restrictions on performance-enhancing drugs (PEDs) pose a collective action problem that cannot be solved and bring a variety of adverse consequences for sport. General prohibitions of PEDs are grounded in claims that they violate the integrity of sport. But there are decisive arguments against integrity of sport-based prohibitions of PEDs for elite sport. We defend a harm prevention approach to PED prohibition as an alternative. This position cannot support a general ban on PEDs, since it provides no basis for prohibiting non-harmful PED use. We argue that a harm prevention approach to restricting PEDs is ethically justified, has better prospects of compliance, is consistent with respecting the integrity of sport, and holds at least a modest prospect of resolving the collective action problem around PED restriction.