艾迪加体部伽玛刀治疗非小细胞肺癌疗效观察

为了观察艾迪加体部伽玛刀治疗非小细胞肺癌的近期疗效及毒副反应,经临床、影像学和病理学诊断90例非小细胞肺癌,采用随机分组原则分为艾迪加体部伽玛刀治疗组和单纯体部伽玛刀治疗组.结果表明,治疗后3个月复查艾迪加体部伽玛刀治疗组总有效率和CR均略高于单纯体部伽玛刀治疗组;治疗后白细胞下降率分别为4.44%和17.78%,症状改善率分别为84.44%和62.22%,KPS提高率分别为62.22%和33.33%,组间差异性明显.可见,艾迪加体部伽玛刀治疗既能提高非小细胞肺癌的局部控制率,又能增强机体免疫功能.     

耐药标志物金属硫蛋白在乳腺癌中的表达

目的:探讨金属硫蛋白(MT)在乳腺癌中表达的状况.方法:采用免疫组化S-P方法.检测57例乳腺癌中MT表达的情况.结果:MT在乳腺癌组织中的总阳性率为59.65%.浸润性导管癌、单纯癌和髓样癌中MT的阳性率分别是69.05%、80.00%、10.00%,髓样癌和其他组有显著性差异(P＜0.01).MT的表达与淋巴是否转移相关性不明显.结论:检测MT为制定化疗方案提供依据.     

血管内皮生长因子在乳腺良、恶性肿瘤表达的临床意义

目的：探讨血管内皮生长因子（VEGF）在乳癌中过表达的临床意义。方法：取乳腺腺瘤47例,乳腺癌95例,利用SABC法检测VEGF阳性率。结果：VEGF在腺瘤中阳性率为25.53%（12/47）,在乳癌中阳性率为54.75%（52/95）;在浸润性癌和有淋巴结转移组阳性率明显高于非浸润性组和无淋巴结转移组（P〈0.05）。结论：VEGF过表达提示患者预后不良,检测VEGF对化疗方案选择有指导意义。     

浅议健身运动的防癌抗癌作用及癌症患者的健身练习方法

近年来我国肿瘤患者特别是恶性肿瘤患者人数急剧上升,患者一旦知道自己的病情之后大都悲观消极,情绪低落。大部分只注重常规治疗,忽视了健身运动带来的良好效果。文章主要介绍了运动防癌的机理以及针对不同的患者采用合适的练习方法和合适的运动量,从而提高该类人群的生活质量。     

乳癌生活现状透视——《白虎郢都》主旨解读

徐春林写作《白虎郢都》就是要告诉我们郢都的白虎不是舒一晴不是黄晓妮,而是功利至上享乐至上欲望至上导致的价值观病变、道德沉沦、人性沦丧的社会隐痰.《白虎郢都》与《废都》与《拯救乳房》最大的不同是它不以单纯赤裸写“性”为卖点和以疗救生理的乳癌为出发点,而是以揭露当下现实社会的隐疾为立足点.有道德感和社会良知的年轻作家用心血酿造“郢都社会”,无情暴露社会的变态,目的就是拯救现实社会的道德和良知.掩藏和暴露在我们身理和心理的“隐痰”,终将根除.拯救乳房是拯救女性,更是拯救我们的母亲.     

Survivin在乳腺癌及大肠癌中表达的临床意义

目的：探讨大肠癌、乳腺癌中生存素的临床意义。方法：收集大肠癌68例,乳腺癌69例,利用SABC免疫组织化学方法,检测Survivin表达状况。结果：大肠癌和乳腺癌中Survivin阳性率分别为63.24%和42.03%,Survivin在大肠癌低分化组和深浸润组阳性率明显高于浅浸润和高分化组;在浸润型乳腺癌组和有淋巴结转移组Survivin阳性率明显增高。结论：Survivin表达与癌组织生物学特性有关;检测癌组织中Sur-vivin表达可以提示预后及指导靶向治疗方案的制定。     

银杏叶槲皮素对人肝癌HepG2细胞增殖与凋亡的影响

目的探讨银杏叶黄酮单体成分槲皮素体外对人肝癌细胞HepG2增殖与凋亡的影响。方法将银杏叶黄酮单体成分槲皮素作用于体外培养的人肝癌细胞HepG2,MTT法检测其对HepG2细胞增殖的影响,缺口末端核苷标记（TUNNEL）法检测其对HepG2细胞凋亡的影响。结果银杏叶黄酮单体成分槲皮素使体外培养的人肝癌细胞HepG2的增殖效率下降,使凋亡细胞数增加（P〈0.01）,两者均呈剂量依赖效应。结论银杏叶黄酮单体成分槲皮素具有与银杏叶总黄酮相似的作用,对体外培养的人HepG2细胞增殖有抑制作用,并能诱导细胞凋亡。     

Using bio-orthogonally catalyzed lethality strategy to generate mitochondria-targeting anti-tumor metallodrugs in vitro and in vivo

Synthetic lethality was proposed nearly a century ago by geneticists and recently applied to develop precision anti-cancer therapies. To exploit the synthetic lethality concept in the design of chemical anti-cancer agents, we developed a bio-orthogonally catalyzed lethality (BCL) strategy to generate targeting anti-tumor metallodrugs both in vitro and in vivo. Metallodrug Ru-rhein was generated from two non-toxic species Ru-N₃ and rhein-alkyne via exclusive endogenous copper-catalyzed azide alkyne cycloaddition (CuAAC) reaction without the need of an external copper catalyst. The non-toxic species Ru-arene complex Ru-N₃ and rhein-alkyne were designed to perform this strategy, and the mitochondrial targeting product Ru-rhein was generated in high yield (>83%) and showed high anti-tumor efficacy in vitro. This BCL strategy achieved a remarkable tumor suppression effect on the tumor-bearing mice models. It is interesting that the combination of metal-arene complexes with rhein via CuAAC reaction could transform two non-toxic species into a targeting anti-cancer metallodrug both in vitro and in vivo, while the product Ru-rhein was non-toxic towards normal cells. This is the first example that exclusive endogenous copper was used to generate metal-based anti-cancer drugs for cancer treatment. The anti-cancer mechanism of Ru-rhein was studied and autophagy was induced by increased reactive oxygen species and mitochondrial damage. The generality of this BCL strategy was also studied and it could be extended to other metal complexes such as Os-arene and Ir-arene complexes. Compared with the traditional methods for cancer treatment, this work presented a new approach to generating targeting metallodrugs in vivo via the BCL strategy from non-toxic species in metal-based chemotherapy.     

PRRSV弱毒疫苗鼻腔接种对母猪子宫黏膜内淋巴细胞的影响

试验研究了猪繁殖与呼吸综合征病毒(PRRSV)弱毒疫苗鼻腔接种对母猪子宫黏膜内淋巴细胞分布的影响.试验选用4月龄长白×大约克夏二元杂交母猪12头.结果表明:鼻腔接种可使猪子宫角、体和颈黏膜上皮内淋巴细胞的数量较对照组增加,差异显著(P＜0.01).经鼻腔接种时,子宫黏膜固有层中多见淋巴细胞聚集成群,并向黏膜腔表面排放.说明PRRSV弱毒疫苗鼻腔接种对母猪子宫黏膜及上皮内淋巴细胞的分布具有显著影响.     

泰州市2009年麻疹减毒活疫苗初免成功率调查分析

目的了解泰州市婴儿麻疹疫苗接种后的免疫成功率情况,为消除麻疹提供参考依据。方法2009年7-8月在姜堰市2个镇对60名满8月龄婴儿,在麻疹疫接种前、接种后1个月分别采集1份血清标本进行抗体滴度检测。结果60名婴儿接种麻疹疫苗前抗体阳性者3名,阳性率5%;接种麻疹疫苗后1个月,抗体阳转率100%。结论泰州市麻疹疫苗接种有效,抗体阳转率高,免疫前抗体阳性者接种麻疹疫苗后可增加抗体滴度。有效保护儿童免受麻疹病毒的侵袭。