内分泌、遗传及运动——急性高原病发病机理、预测、诊断和干预

急性高原病(AMS)是高原暴露时因高原低氧而在数小时至数天内出现的临床综合征,症状包括头痛、恶心、食欲减退、疲倦、眼花及睡眠障碍,在高原旅居者中(>2 500 m)具有高发生率。尽管有关AMS的研究已开展百余年,其病理生理机制目前仍不明确,但已有研究表明,运动、体液潴留、睡眠时低氧血症、通气反应降低、心功能不全和遗传等在其发生中起重要作用。综述了内分泌、遗传及运动对AMS的影响,以期为AMS的预防及诊疗提供参考。     

复方理气中药对女子举重运动员血清GH水平及内分泌功能影响的研究

观察6名女子举重运动员服用复方理气中药对血清生长激素(GH)水平及内分泌功能的影响,结果显示:大强度运动训练后即刻血清GH和血皮质醇(C)水平显著性升高(P＜0.05),但与服药前相比无明显差异(P＞0.05);安静时睾酮(T)水平和血卵泡刺激素(FSH)水平与服药前相比显著性升高(P＜0.05).表明复方理气中药可以促进女举运动员的内分泌功能.     

Correlations between serum and salivary hormonal concentrations in response to resistance exercise

Abstract

The aim of present study was to examine the relationships between serum and salivary values of free testosterone, dehydroepiandrosterone, and cortisol before and after a session of resistance exercise. Twenty-eight healthy men (mean age 40 years, s = 4) participated in the present study. Serum and salivary samples were collected at rest and after a multiple-sets resistance exercise protocol, of approximately 25 minutes duration. Concentrations of free testosterone, dehydroepiandrosterone, and cortisol were measured using radioimmunoassay kits. No significant correlation was observed between serum free testosterone and salivary testosterone (r = 0.22 to 0.26, P > 0.05). Serum cortisol was significantly correlated with salivary cortisol before (r = 0.52, P = 0.005) and after (r = 0.62, P = 0.001) the exercise protocol. Serum and salivary concentrations of dehydroepiandrosterone were significantly correlated before (r = 0.68, P < 0.001) and after (r = 0.7, P < 0.001) exercise. The results of the present study suggest that even under exercise conditions, the salivary values of cortisol and dehydroepiandrosterone can reflect the behaviour of these hormones in blood. However, further studies are necessary to verify if salivary testosterone reflects the behaviour of serum free testosterone during resistance exercise.     

双酚A的环境行为研究进展

双酚A(BPA)是重要的化工原料苯酚和丙酮的衍生物,主要用于合成高分子材料。研究表明,BPA具有内分泌干扰作用,是环境荷尔蒙物质。本文综述了双酚A的环境行为研究进展,包括样品的采集、保存、前处理方法、分析方法、各环境介质中的浓度水平及其归趋行为。