绞股蓝浸出液的抑瘤作用

定期给荷瘤小鼠注射或灌服一定剂量浓度的绞股蓝浸出液后,小鼠体质增强,胸腺的萎缩速度减慢,每克体重的胸腺和脾脏重均显著高于对照组.胸腺与脾脏每克重细胞数增多.每克体重的瘤重明显降低,瘤细胞数减少,取荷瘤小鼠胸腺淋巴细胞与瘤细胞离体混合培养后,被致敏的淋巴细胞的“粘瘤”和“钻瘤”作用加强,癌细胞发生轻度皱缩,淋巴细胞钻入的癌细胞发生裂解,碎片逐渐增多,而淋巴细胞的形态和数量无变化.实验结果表明:纹股蓝浸出液具有增强荷瘤小鼠免疫力和抑制;肿瘤生长的作用。     

Imbalanced expression of mitogen-activated protein kinase phosphatase-1 and phosphorylated extracellular signal-regulated kinases in lung squamous cell carcinoma

Objective  

Mitogen-activated protein kinases (MAPKs) are correlated with a more malignant phenotype in many cancers. This study was designed to evaluate the predictive value of the expression of MAPK phosphatase-1 (MKP-1) and phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK_1/2), as the key regulatory mechanism of the MAPKs, in lung squamous cell carcinoma (SCC).     

Up-regulation of mitochondrial antioxidation signals in ovarian cancer cells with aggressive biologic behavior

Objective  

Recently, a high frequency of mutations in mitochondrial DNA (mtDNA) has been detected in ovarian cancer. To explore the alterations of proteins in mitochondria in ovarian cancer, a pair of human ovarian carcinoma cell lines (SKOV3/SKOV3.ip1) with different metastatic potentials was examined.     

早期饲喂对肉鸡生长性能和肠道消化酶的影响

为研究早期饲喂对肉鸡生长性能和肠道消化酶的影响,选择360只刚出壳的AA肉用雏鸡,采用单因子试验设计,随机分成4个处理组,每组4个重复,每个重复20只,试验1组出壳后12 h饲喂,试验Ⅱ组出壳24 h后饲喂,试验Ⅲ组出壳36 h后饲喂,对照组出壳48 h后饲喂.饲喂相同日粮,试验期为6周.于21日龄和42日龄分别测定肉鸡进行生产性能和酶活性.结果表明：早期饲喂显著提高了肉鸡的日增重,降低了料重比,试验Ⅰ组和试验Ⅱ组与对照组相比,日增重分别提高了4.19%和3.70%,料重比分别降低5.61%和5.10%,差异显著（P〈0.05）;试验Ⅰ组、试验Ⅱ组和试验Ⅲ组肠道消化酶水平高于对照组.早期饲喂提高了肉鸡肠道消化酶水平,以出壳后12 h饲喂最好.     

磁处理党参药液对消化功能影响的药效研究

研究磁处理党参药液对消化功能影响的药效作用.用炭末法比较生理盐水、磁处理党参药液与非磁处理党参药液对小鼠肠推进运动的影响;用麦特(Mett)氏法比较正常对照组、非磁处理党参药液组与磁处理党参药液组的胃蛋白酶活性.与生理盐水组比较,磁处理药液组小鼠肠的炭末推进率显著增加(P0.01);与非磁处理药液组比较,磁处理药液组小鼠肠的炭末推进率显著减小(P0.01).与正常对照组比较,磁处理药液组的胃蛋白酶活性显著增强(P0.01);与非磁处理药液组比较,磁处理药液组的胃蛋白酶活性亦显著增强(P0.01及P0.05).党参磁处理药液对小鼠肠的推进及胃蛋白酶活性有明显作用.     

甲状腺癌骨转移的诊疗措施的个例报道及其文献回顾

研究目的：探究甲状腺癌骨转移的规范诊疗措施,为提高甲状腺癌骨转移的生存期提供指导。创新要点：本例病人通过普外科、骨科联合手术,内分泌激素替代治疗,I^131治疗等多学科联合治疗,取得较好的疗效,对探究甲状腺癌骨转移的规范化诊疗措施有重要的指导意义。研究方法：本文分析本科室一例甲状腺癌骨转移病人,同时搜集了1996年至2013年中文文献报道的甲状腺癌骨转移患者11例,通过统计其病理类型、手术方式、转移部位、随访资料等,讨论其规范化治疗方式。重要结论：彻底的术前检查对发现甲状腺癌骨转移至关重要。甲状腺癌骨转移需要多学科协同治疗,手术治疗仍为首选,联合手术的激素替代治疗、I^131治疗、二膦酸盐治疗是较好的选择。放疗的作用仍需大样本数据的评估。     

Hydrogen Breath Tests in Gastrointestinal Diseases

Hydrogen breath tests are widely used to explore pathophysiology of functional gastrointestinal (GI) disorders. Small intestinal bacterial overgrowth (SIBO) and carbohydrate malabsorption are disorders detected by these tests that have been proposed to be of great importance for symptoms of GI diseases. Glucose hydrogen breath test is more acceptable for diagnosis of SIBO whereas lactose and fructose hydrogen breath tests are used for detection of lactose and fructose maldigestion respectively. Lactulose hydrogen breath test is also used widely to measure the orocecal transit time for GI motility. These methods are noninvasive and inexpensive. Many patients with functional gut disorders are unaware of the relationship between diet and GI symptoms they present. In particular, patients with chronic symptoms may regard their condition as normal and may not be aware that their symptoms can be effectively managed following a proper diagnosis. Patients with symptoms of abdominal pain, bloating, flatulence and altered bowel movements (diarrhea and constipation), or with a medical diagnosis of irritable bowel syndrome or celiac disease, may have undiagnosed carbohydrate malabsorption or SIBO. Hydrogen breath tests are specific and sensitive diagnostic tests that can be used to either confirm or eliminate the possibility of carbohydrate malabsorption or SIBO in such patients. Breath tests, though valuable tools, are underutilized in evaluating dyspepsia and functional bloating and diarrhea as well as suspected malabsorption. However, because of their simplicity, reproducibility and safety of procedure they are now being substituted to more uncomfortable and expensive techniques that were traditionally used in gastroenterology.     

对Fordtran等“长时间剧烈运动中的胃排空与肠吸收”一文的述评

关于流汗所导致的身体水分以及电解质的流失和运动中肌糖原的耗尽是引起疲劳的关键因素这一观点已被广泛接收,但是运动营养方面的知识尚未被完全应用于自然科学的研究中,因而运动的强度是否会影响胃排空等一系列问题就显现出来。为此。Fordtran和Saltin设计了一个实验：在跑台上,研究对象以71％最大摄氧量运动,分两天进行胃排空和肠道吸收功能的测试？研究结果显示：运动强度对胃排空和小肠的吸收没有显著影响．．此研究探索了：碳水化合物一电解质溶液以及水在被消化时胃肠道的基本功能,提示了运动员在大强度训练中或者在炎热环境下补充汗液的流失以及提供碳水化合物、电解质溶液作为补给是可行的,但本次研究仅限于71％的最大摄氧量,因此高于或者低于此强度的运动是否会影响胃肠道的功能需以后的研究进一步证明。     

青年食管癌与中老年食管癌外科诊治的比较研究

分析青年与中老年食管癌患者的临床特征及外科治疗效果。回顾性分析49例青年和98例中老年食管癌患者的临床资料。结果:青年食管癌占同期食管癌的6.55%,两组患者在性别比例、肿瘤病变部位、病理类型、分化程度等差异无统计学意义(P>0.05);在术后病理分期、根治性切除率、术后并发症发生率上差异均有统计学意义(P<0.05);青年组与中老年组的手术死亡率分别为0.0%和2.0%,两组生存率差异无统计学意义(P>0.05)。结果表明,青年人食管癌肿瘤病期偏晚,手术切除率更低,术后并发症发生率及手术死亡率优于中老年组,两者在生存预后差别无统计学意义。     

大肠癌组织中血管内皮细胞生长因子的表达

应用免疫组化方法,比较性地研究了大肠癌组织及其同一患者形态正常大肠粘膜组织中血管内皮细胞生长因子的表达,分析血管内皮细胞生长因子表达与大肠癌发生的年龄、性别、病理分期等因素的关系。结果显示,癌组织与正常大肠粘膜的血管内皮细胞生长因子表达存在明显差异,血管内皮细胞生长因子的表达与大肠癌患者年龄、性别、分化程度等因素不存在相关性,而与Ducks分期存在明显相关性。表明肿瘤血管的生成在大肠癌的生长发展方面起着至关重要的作用,血管内皮细胞生长因子的检测可以作为大肠癌诊断的重要参考指标。