太极拳锻炼对中老年人血脂、脂蛋白代谢的影响

为探索太极拳运动对中老年人健身防病的作用，测定了长期坚持太极拳运动的中老年知识分子锻炼组与非锻炼组血脂、脂蛋白代谢等指标的变化情况。结果表明：常年坚持太极拳运动可降低血脂、改善脂类代谢，预防心血管疾病的发生，从而起到延缓衰老的作用。     

牛磺酸对运动大鼠心肌和大脑脂褐素及脂质过氧化的影响

笔者以力竭运动为模型 ,观察了牛磺酸对大鼠心肌和大脑中脂褐素含量、MDA、SOD及GSH的变化 ,探讨了牛磺酸对运动大鼠心肌和大脑脂褐素及脂质过氧化的影响。发现力竭运动可造成大鼠心肌和大脑中脂褐素含量、MDA水平显著增加 ,造成大鼠心肌和大脑中SOD和GSH显著下降 ;而补充牛磺酸可抑制力竭运动后大鼠心肌和大脑中脂褐素含量和MDA水平的显著增加 ,抑制大鼠心肌和大脑中SOD活性和GSH含量显著下降。结论 :牛磺酸可防止运动后大鼠心肌和大脑脂褐素和脂质过氧化增加 ,有保护细胞和抗衰老作用。     

维生素E和硒对运动大鼠心肌线粒体抗氧化能力的影响

给大鼠腹腔注射亚硒酸钠维生素Ｅ复合注射液０．４ｍｌ／Ｋｇ．Ｗ．Ｄ，４５天，测定疲劳性游泳前后心肌线粒体抗氧化能力的有关指标。发现，亚硒酸钠维生素Ｅ使大鼠游泳耐力提高了7５．８２％，并抑制大鼠疲劳性游泳后心肌线粒体脂质过氧化程度．提高超氧化物歧化酶（ＳＯＤ），谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）的活性；在对膜结构的保护上，硒、维生素Ｅ的作用主要体现在能抑制疲劳性运动导致的线粒体膜流动性的降低，保护膜蛋白功能的正常。     

有氧运动升高脂质清除障碍的ApoE~(-/-)小鼠血脂

目的：探讨ＡｐｏＥ在有氧运动调节脂质代谢机制中的作用。方法：应用基因调皮除的ＡｐｏＥ－／－鼠建立运动模型。结 果：对比游泳 １２周（２ｈ ｘ ６ｄ）前后结果。ＡｐｏＥ－／－鼠 ＴＣ（１８． ５±２． ２７ ｍｍｏｌ／Ｌ ｖｓ ２７． ９±４．６３ｍｍｏｌ／Ｌ，Ｐ＜０． ０１）和 ＴＧ （１．０９±０．２６ｍｍｏｌ／Ｌ ｖｓ　１． ５２±０．３７ ｍｍｏｌ／Ｌ，Ｐ＜０．０１）显著升高，睾丸总胆固醇水平下降。与 Ｃ５７ＢＬ／６Ｊ对照鼠游 泳前后的变化趋势相反（ＴＣ：１．７６±０．３１ ｍｍｏｌ／Ｌ ｖｓ１．３２±０．３２ ｍｍｏｌ／Ｌ，Ｐ＜０．０５；ＴＧ：０．８６±０．１４ ｍｍｏｌ／Ｌ ｖｓ ０．４５±０．０４３ ｍｍｏｌ／Ｌ，Ｐ＜０．０５）。结论：ＡｐｏＥ－／－鼠运动后血脂升高。反映了运动促进组织脂质动员入血和 ＡｐｏＥ缺 失引起脂质清除障碍的机制；也说明运动调节血脂的关键机制包括ＡｐｏＥ参与的受体依赖脂质清除途径；同时提示 脂质清除障碍时，依靠有氧训练改善血脂状况的效果可能不佳。     

Association of Inflammatory Cytokines,Lipid Peroxidation End Products and Nitric Oxide with the Clinical Severity and Fetal Outcome in Preeclampsia in Indian Women

Preeclampsia is a multisystem disorder associated with maternal hypertension, placental abnormalities and adverse fetal outcomes. The various pathways involved in its etiology include endothelial dysfunction, inflammatory milieu, lipid peroxidation and immunological imbalance. The present study was conducted to evaluate the causative and predictive role of nitric oxide, lipid peroxidation end products (MDA) and inflammatory cytokines (IL-6, TNF-α) in clinical presentation, severity and fetal outcome in preeclampsia. The study population was divided into 3 groups- Non- pregnant females comprising the control population; G1 and G2 groups included normal pregnant and pregnant females with preeclampsia with 50 patients in each group. Nitric Oxide and MDA levels were found to be highest in the preeclamptic patients as compared to other two groups. ROC curve analysis shows the superiority of the inflammatory markers as determinants of severity of preeclampsia which suggests the emerging role of pro inflammatory markers in the various pathological changes in preeclampsia. TNF-α emerged as the best marker in multivariate analysis and thus, has the potential for being used as a marker for PIH. Our study illustrates the multifactorial etiology of preeclampsia involving oxidative stress, proinflammatory milieu and endothelial dysfunction.     

Effect of sulphurous mineral water in haematological and biochemical markers of muscle damage after an endurance exercise in well-trained athletes

Abstract

To investigate the effects of sulphurous mineral water (SMW) after a hydroponic treatment on muscle damage, antioxidant activity and peripheral blood changes induced by submaximal exercise. Thirty well-trained male triathletes were supplemented with SMW or placebo: 3 weeks of placebo, 30 days of wash out and 3 weeks of SMW. After both periods, participants ran for 2 h at 70% maximal aerobic speed. Antioxidant enzymes, lipid peroxidation, antioxidant capacity and blood cell markers were compared between placebo and SMW at pre-exercise (T₀), immediately post-exercise (T₁), 24 h post-exercise (T₂) and 48 h post-exercise (T₃). Total thiols decreased until T₃ vs. T₀ for both placebo and SMW; transient red blood cells, haemoglobin and haematocrit increased were shown at T₁ vs. T₀ and for leucocytes until T₂ vs. T₀, only for placebo group. Total thiols increased significantly in SMW vs. placebo at T₀; Thiobarbituric acid reactive species was significantly higher at T₀, T₁, T₂ and T₃; catalase increased significantly at T₁; creatine phosphokinase decreased significantly at T₁, T₂ and T₃, although no significant differences were found at T₀. Furthermore, red blood cells, haemoglobin and haematocrit were significantly higher and leucocytes were significantly lower at T₀ and T₁ in SMW group vs. placebo group. This study suggests that three weeks of SMW supplementation may protect from exercise-induced muscle damage.     

体育舞蹈对绝经女性激素、血脂、免疫及骨密度相关指标的影响

目的：探讨体育舞蹈对绝经女性雌激素、血脂、免疫及骨密度相关指标的影响。方法：对28名身心健康的绝经女性进行6个月的体育舞蹈锻炼,测试锻炼前后受试对象的血清雌二醇（E2）、孕酮（P）、睾酮（T）等激素指标;甘油三脂（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）等血脂指标;免疫球蛋白IgA、IgM、IgG等免疫指标和腰椎、股颈、股骨大转子处骨密度的变化,评价体育舞蹈运动对绝经女性的影响。结果：6个月的体育舞蹈锻炼后,绝经女性的E2较锻炼前提高（p〈0.01）,T水平下降（p〈0.01）;TG、TC、LDL-C较锻炼前降低（p〈0.05或p〈0.01）HDL-C较锻炼前提高（p〈0.01）,IgA、IgM、IgG较锻炼前提高（p〈0.05或p〈0.01）;腰椎L2-4、股骨颈、股骨大转子骨密度较锻炼前提高（p〈0.01）。结论：体育舞蹈锻炼对绝经女性雌激素、血脂及免疫机能有积极影响,能显著提高腰椎L2-4、股骨颈、股骨大转子骨密度。     

饮茶与参加太极运动对老年人体成分和血脂水平的影响

目的：观察饮茶和参加太极运动锻炼联合干预对老年人身体成分和血脂水平的影响,探讨饮茶与参加太极运动联合干预在减肥降脂方面的协同作用。方法：将刚刚加入吕梁市太极协会的128名老年人（之前未进行过太极锻炼）分为饮茶组与非饮茶组,进行太极运动锻炼干预。锻炼前分别采用生物电阻抗法测量体成分,全自动生化分析仪测定血脂指标,10周后复测。结果：饮茶组和不饮茶组老年人太极运动干预前后体脂百分比、血脂六项均有显著变化,且饮茶组效果好于不饮茶组（P〈0.05）,参加太极运动和饮茶在减肥降血脂方面具有叠加效应。结论：饮茶与参加太极运动联合干预在改善老年人身体成分和血脂水平方面具有协同作用。     

沙棘油对SO_2污染环境下运动训练大鼠抗氧化能力的影响

采用动物实验的方法,对不同二氧化硫浓度污染下运动训练大鼠骨骼肌及脑组织脂质过氧化程度的影响进行了研究。结果显示：沙棘油可提高SO2污染环境下大鼠的机体自由基防御系统的能力,对延缓机体疲劳有一定的作用。     

Lipid peroxidation of fish oils

Fish and fish oils are the richest sources of ω-3 fatty acids. However, they are susceptible to lipid peroxidation due to their high degree of unsaturation. In the present study, the level of thiobarbituric acid reactive material in various fish oils available in the market with and without added Vitamin E was determined. The peroxide levels in fish oil heated to food frying temperature of 180°C and the effect of addition of vitamin E has also been studied. The results indicate that the peroxide levels in almost all the products available in the market were abnormally high irrespective of their Vitamin E content. This might be due to the inefficient methods used for processing and storage of fish oils. Addition of vitamin E was found to have a significant effect in lowering the rate of peroxidation of fish oil during thermal stress, showing that association of antioxidants with ω-3 fatty acids lowers the rate of lipid peroxidation.