艾迪加体部伽玛刀治疗非小细胞肺癌疗效观察

为了观察艾迪加体部伽玛刀治疗非小细胞肺癌的近期疗效及毒副反应,经临床、影像学和病理学诊断90例非小细胞肺癌,采用随机分组原则分为艾迪加体部伽玛刀治疗组和单纯体部伽玛刀治疗组.结果表明,治疗后3个月复查艾迪加体部伽玛刀治疗组总有效率和CR均略高于单纯体部伽玛刀治疗组;治疗后白细胞下降率分别为4.44%和17.78%,症状改善率分别为84.44%和62.22%,KPS提高率分别为62.22%和33.33%,组间差异性明显.可见,艾迪加体部伽玛刀治疗既能提高非小细胞肺癌的局部控制率,又能增强机体免疫功能.     

Targeting HSPA1A in ARID2-deficient lung adenocarcinoma

Somatic mutations of the chromatin remodeling gene ARID2 are observed in ∼7% of human lung adenocarcinomas (LUADs). However, the role of ARID2 in the pathogenesis of LUADs remains largely unknown. Here we find that ARID2 expression is decreased during the malignant progression of both human and mice LUADs. Using two Kras^G12D-based genetically engineered murine models, we demonstrate that ARID2 knockout significantly promotes lung cancer malignant progression and shortens overall survival. Consistently, ARID2 knockdown significantly promotes cell proliferation in human and mice lung cancer cells. Through integrative analyses of ChIP-Seq and RNA-Seq data, we find that Hspa1a is up-regulated by Arid2 loss. Knockdown of Hspa1a specifically inhibits malignant progression of Arid2-deficient but not Arid2-wt lung cancers in both cell lines as well as animal models. Treatment with an HSPA1A inhibitor could significantly inhibit the malignant progression of lung cancer with ARID2 deficiency. Together, our findings establish ARID2 as an important tumor suppressor in LUADs with novel mechanistic insights, and further identify HSPA1A as a potential therapeutic target in ARID2-deficient LUADs.     

太极拳运动对中老年人体质健康功能及成分影响研究

采用实验对比、文献资料等方法,通过对兰州市参加太极拳健身锻炼两年以上中老年的心肺功能、身体成分、脂质代谢各项指标测试发现太极拳运动对部分慢性疾病心血管及微循环功能具有良好的影响作用,对缓解病症、康复及延缓病理性衰老具有特殊功能．长期坚持参加太极运动,可增强体质,提高身体、机能状态和健康水平。对预防心血管疾病和老年肌肉萎缩、骨质疏松等有积极作用．     

Quick dissection of the segmental bronchi

Knowledge of the three‐dimensional anatomy of the bronchopulmonary segments is essential for respiratory medicine. This report describes a quick guide for dissecting the segmental bronchi in formaldehyde‐fixed human material. All segmental bronchi are easy to dissect, and thus, this exercise will help medical students to better understand the bronchopulmonary segments. Anat Sci Educ 2010. © 2010 American Association of Anatomists.     

16周健身跑运动前后中年男性肺通气功能变化研究

探讨健身跑运动对中年男子肺通气功能的影响。45名高体脂水平中年男子随机分成小强度运动组（L2）,中等强度运动组（L4）和对照组（C组）。L2组和L4组进行两种不同强度的健身跑运动。16周运动干预后,L2组和L4组受试者体脂百分比和体重指数较运动前明显降低（P〈0.01）,肺功能均有改善。体脂百分比的降低与FVC,MVV等肺功能各指标的增高呈负相关（P〈0.05）。L2组和L4组体脂百分比及肺功能各指标运动前后的变化量无显著性差异（P〉0.05）。C组体脂百分比有所增加（P〈0.05）,肺功能无变化（P〉0.05）。结果说明16周适量健身跑运动对高体脂水平中年男子肺通气功能、身体成分有良好的改善作用,运动减肥有益于肺功能的改善,其机理有待于进一步的研究。     

高原训练对残疾田径运动员肺通气功能的影响

通过对北京市残疾田径运动员在云南昆明进行为期五周的高原训练进行跟踪,观察运动员在平原—高原—平原交叉环境下肺功能的变化规律,分别对MVV、VC、FVC、FEV1%、PEF、PEF25～75%用力肺活量平均呼吸流速各指标进行测试。结果显示:高原残疾田径运动员训练后肺功能各指标有明显上升,高原训练有利于残疾田径运动员肺通气功能的提高。     

Comparison of Hydrostatic Weighing at Residual Volume and Total Lung Capacity in Children

Abstract

The influence of perceptions of the motivational climate and perceived ability on situational motivation and the physical activity behavior of 213 male and 229 female adolescent physical education students (M age= 12.56 years; SD = 0.96) was examined over a 3-day period. A significant age by gender interaction emerged, with physical activity declining from the sixth to eighth grade. The decline was more pronounced among female than male students. Perceptions of a mastery climate were strongly related to more self-determined forms of situational motivation. In contrast, perceptions of a performance climate were strongly related to less self-determined forms of situational motivation. Results of a hierarchical regression analysis revealed gender, perceived ability, and perceptions of a mastery climate to explain a significant amount of variance in physical activity. These findings suggest that promoting a mastery oriented motivational climate in physical education will foster self-determined situational motivation and physical activity.     

"轻体育"对职业女性心肺功能及心理的影响

“轻体育”也称“轻松体育”或“快乐体育”,是大众体育的一种形式.职业女性平时的锻炼是不够的,经过对持续参加“轻体育”锻炼的职业女性有关心肺功能和心理方面的测试,结果显示,长期的“轻体育”运动可使她们的心肺功能、精神状态及心理状态得到明显改善.     

CYP1A1多态性在上海人群中的分布

由于单核苷酸多态性(SNPs)在寻找致病基因，了解遗传多样性、环境与基因的相互作用方面有重大价值，SNPs研究已越来越多地引起了学术界和产业界的兴趣．CYP1A1编码的酶在烟草的主要几类前致癌物(如PAHs和芳香胺类物质)的代谢活化中有重要作用，其多态性与个体对环境相关的癌症的易感性密切相关．本研究采用PCR-RFLP技术在上海人群中，对CYP1Al的两个SNPs：CYP1A1 m1和m2进行了基因分型．结合其它已发表的数据，我们的研究表明，在中国人群的不同群体中，m1等位基因的频率分布比较一致，而m2等位基因的频率分布则存在着显著的不同．     

有氧训练对提高学生肺通气功能的调查分析

为了解有氧训练对学生肺通气功能的影响,作者对40名年龄、身高、体重、胸围等可影响因素相似的男性学生配对进行了肺功能调查。调查结果表明各项测试指标均以实验组为高,但与1960年吴氏标准比较,MBC和FEV1,增加不够理想,结果提示肺功能的发育虽与先天能力有关,但有氧训练可充分发挥这种能力的潜在力量,高等学校体育教学应以提高学生心肺机能为主,采取各种强度的有氧训练,以不断提高学生肺功能的发育。