The effect of acute aerobic exercise on central arterial stiffness,wave reflections,and hemodynamics in adults with diabetes: A randomized cross-over design

BackgroundIndividuals with diabetes have greater central arterial stiffness, wave reflections, and hemodynamics, all of which promote the accelerated cardiovascular pathology seen in this population. Acute aerobic exercise has been shown to be an effective strategy for reducing central arterial stiffness, wave reflections, and hemodynamics in healthy individuals; however, the effects of acute aerobic exercise in reducing these outcomes is not well established in people with diabetes. Recently, implementation of high-intensity interval exercise (HIIE) has shown superior improvements in cardiovascular health outcomes when compared to traditional aerobic exercise. Yet, the effect of HIIE on the aforementioned outcomes in people with diabetes is not known. The purpose of this study was to (i) describe the central arterial stiffness, wave reflections, and hemodynamic responses to a bout of HIIE and moderate-intensity continuous exercise (MICE) in adults with diabetes; and (ii) compare the effects of HIIE and MICE on the aforementioned outcomes.MethodsA total of 24 adult men and women (aged 29–59 years old) with type 1 (n = 12) and type 2 (n = 12) diabetes participated in a randomized cross-over study. All participants completed the following protocols: (i) HIIE: cycling for 4 × 4 min at 85%–95% of heart rate peak (HR_peak), interspersed with 3 min of active recovery at 60%–70%HR_peak; (ii) MICE: 33 min of continuous cycling at 60%–70%HR_peak; and (iii) control (CON): lying quietly in a supine position for 30 min.ResultsA significant group × time effect was found for changes in central systolic blood pressure (F = 3.20, p = 0.01) with a transient reduction for the HIIE group but not for the MICE or CON groups. There was a significant group × time effect for changes in augmentation index at a heart rate of 75 beats/min (F = 2.32, p = 0.04) with a decrease following for HIIE and MICE but not for CON. For all other measures of central arterial stiffness and hemodynamics, no significant changes were observed (p > 0.05).ConclusionA bout of HIIE appears to lead to a greater transient reduction in central systolic blood pressure than the reduction observed following MICE; however, both HIIE and MICE improved augmentation index at a heart rate of 75 beats/min in people with diabetes. There was no significant difference in response to HIIE and MICE in all outcomes. This provides preliminary evidence on the role of HIIE on such outcomes in people with diabetes.     

Reliability of arterial spin labelling measurements of perfusion within the quadriceps during steady-state exercise

Arterial spin labelling (ASL) provides a potential method to non-invasively determine muscle blood flow and examine the impact of interventions such as supplementation and training. However, it's a method with intrinsically low signal, leading to limitations in accuracy and temporal resolution. To examine these limitations, the current study measured perfusion via ASL on three occasions in the rectus femoris of 10 healthy adults, during light and moderate exercise, over three different exercise durations. For data sampled over 9 min, light intensity exercise gave an average perfusion of 35.0 ± 5.1 ml/min.100g^?1 with a coefficient of variation (COV) of 16% and single intraclass correlation coefficient (ICC) of 0.67. For the moderate bout, perfusion was 51.3 ± 5.6 ml/min.100g^?1 (COV 10%, ICC 0.82). When the same data were analyzed over 5 min 24 s, perfusion was 37.8 ± 11.13 (COV 30%, ICC 0.13) during light and 49.5 ± 8.8 ml/min.100g^?1 (COV 18%, ICC 0.52) during moderate exercise. When sampling was reduced to 1 min 48 s, perfusion was 41.2 ± 13.7 (COV 33%, ICC 0.26) during light and 49.5 ± 13.6 ml/min.100g^?1 (COV 28%, ICC 0.04) during moderate exercise. For 9 min a significant perfusion difference was found between the exercise intensities; however, this was not the case for sampling over 5 min 24 s or 1 min 48 s. Such findings illustrate the potential of ASL to non-invasively monitor muscle perfusion under steady-state conditions, but highlight that extended exercise protocols are necessary in order to generate date of sufficient reliability to be able to discriminate intervention dependent perfusion differences.     

吸血蛭与非吸血蛭间的氨基酸比较研究

为探究传统中药水蛭的药用成分，更好地开发利用蛭类资源，本文通过高效氨基酸分析仪，分析了云南四种蛭类的氨基酸组成．结果表明吸血蛭与非吸血蛭在氨基酸组成上有明显差异．结合以往实验，分析了非吸血蛭活血化瘀的可能药用成分，为合理开发利用蛭类资源提供了资料和建议．     

便携式多参数监护仪的研制

本介绍了一种便携式人体多参数监护仪的研制方法，包括：心电检测、血压检测、血氧饱和度检测、呼吸检测模拟电路的设计，以及存储单元、A／D转换器、USB通讯口等接口模块的设计。     

利用Winsock控件编写网络通信程序

介绍了控件的主要属性、事件和方法,以及利用控件开发局域网通信程序的方法。WinsockWinsock     

感性设备同名端的判断

本文介绍了一些常见感性设备同名端判断的方法,对其正确使用和维护有重要的实际意义。     

246例体检儿童超重或肥胖与血脂异常调查

目的调查苏北地区儿童的体质指数(BMI)水平和血脂水平,探讨儿童的超重或肥胖与血脂异常的关系。方法统计分析246例体检儿童的BMI指数和血脂水平,以BMI指数水平将246例体检儿童分为正常组和超重或肥胖组,比较两组间多种血脂水平异常的发生率。结果本地区儿童的血脂水平:TC 3.65±0.61 mmol/L,TG 0.96±0.41mmol/L,LDL-C 1.82±0.57 mmol/L,HOL-C 1.47±0.32 mmol/L。BMI水平17.1±2.5。超重或肥胖组血脂异常的发生率:TC 20.0%,TG 53.3%,LDL-C 33.3%,三种血脂水平异常的发生率均显著高于正常组(P<0.01)结论在进行心脑血管疾病早期预防时,应将肥胖或超重儿童这一群体作为重点干预对象,积极预防和治疗肥胖或超重儿童的血脂异常。     

Study of Resistin gene expression in peripheral blood mononuclear cell and its gene polymorphism in a small range population

INTRODUCTION Recently discovered as an endocrine organ, adi-pose tissue can secrete many cytokines such as Re-sistin, adiponectin and free fatty acids, and receives much attention in the study of insulin resistance and type 2 diabetes mellitus (T2DM). As a peptide hor-mone secreted by adipocyte, Resistin is considered to be the linkage between obesity and insulin resistance (Steppan et al., 2001). Most studies on Resistin in-vestigate adipose tissue. In this experiment we de-tected t…     

A novel algorithm for Ethernet-passive-optical-network dynamic bandwidth allocation based on threshold

The Ethernet passive optical network (EPON) is the next generation of broad-band network technique. A crucial issue in EPONs is the sharing of uplink bandwidth among optical network units (ONUs). This article provides a novel dynamic bandwidth allocation algorithm, i.e. threshold dynamic bandwidth allocation (TDBA), which is based on adaptive threshold, to increase resource utilization. The algorithm uses ONU data-transmitting rate to adjust optical line terminal (OLT) receiving data threshold from an ONU. Simulation results show that this algorithm can decrease average packet delay and increase network throughput in a 10G EPON system.     

终端滑模控制器设计在永磁同步电动机中的应用

文中考虑了一类永磁同步电动机的终端滑模控制器设计问题.在控制器设计中利用中继切换控制使系统在给定的当前控制律的作用下运行到某一特定状态（或某一特定区域）后,控制律被切换到有限时间收敛的终端滑模控制器,使得系统在有限时间内达到平衡状态.终端滑模控制器的设计保证了闭环系统所有信号的有界性和平衡点的全局稳定性,以及系统在有限时间内精确地跟踪给定的参考信号.最后,通过一个数值仿真验证了所提算法的正确有效性.