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Objective: To study the clinical therapy and prognosis in children with transient congenital hypothyroidism (CH).Methods: Fifty-seven children with CH diagnosed after neonatal screening were treated with low-dosage levothyroxine (L-T4).Follow-up evaluation included the determination of TT3, TT4 and TSH serum levels and the assessment of thyroid gland morphology, bone age, growth development and development quotients (DQ). A full check-up was performed at age 2, when the affected children first discontinued the L-T4 treatment for 1 month, and one year later. Development quotients were compared (16.25±3.87) μg/d. Mean duration of therapy was (28.09±9.56) months. No significant difference was found between study group and control group in the DQ test (average score (106.58± 14.40) vs (102.4±8.6), P>0.05) and 96.49% of the CH children achieved a test score above 85. Bone age, 99mTc scans and ultrasonographic findings were all normal, and evaluation of physical development was normal too, as were the serum levels of TT3, TT4 and TSH after one year of follow-up. Conclusion: A L-T4 dosage of and physical development at age 2. So it is possible for CH children to stop taking medicine if their laboratory findings and physical development are all normal after regular treatment and 2~3 years of follow-up. 相似文献
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《中国科学院院刊》2009,(4):435-436
氟喹诺酮(沙星类)是目前我国抗菌药物3大主力品种之一,市场规模达100亿元左右,对保障我国人民身体健康发挥着重要作用。上海药物所杨玉社研究员、嵇汝运院士及团队从1993年开始,对氟喹诺酮类抗菌药物合成方法学、构效关系、成药性等开展了深入系统的研究工作。他们采用结构优化的策略,潜心研究左旋氧氟沙星的基因结构.药效关系、结构一代谢特征关系、结构一毒性关系,合成了一系列新的化合物,最终筛选出具有新化学结构的氟喹诺酮类抗菌药物——盐酸安妥沙星。该药在2008年8月申报国家“重大新药创制”重大科技专项时,获得审评专家的高度认可,评分列为化学类新药第一名。并于2009年4月15日获得国家食品药品监督管理局颁发新药证书,即将上市。 相似文献
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INTRODUCTION At this moment, novel concepts of “negative” media, having negative refraction and/or “double negativity” and their physical consequences and plausible applications are drawing considerable at- tention from the science and engineering community. In the past few years, considerable progress has been made in electromagnetic (EM) waves. It is our wish to generalize such concepts to acoustic waves. Since the concept of negative refraction, negative constitutive relationships… 相似文献
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Analytical solution for electromagnetic scattering from a sphere of uniaxial left-handed material 总被引:2,自引:0,他引:2
INTRODUCTION The concept of left-handed materials (LHM for short, also called negative index materials) was in- troduced by Veselago (1968). An LHM has both negative permittivity and negative permeability, which makes the wave vector, the electric-field vector, and the magnetic-field vector in the LHM obey the left-hand rule. Experimental verifications for the existence of an LHM were made and its use as a perfect lens was suggested (Pendry, 2000; Shelby et al., 2001a; 2001b; Smith … 相似文献
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网球左旋发球和右上旋发球技术探析 总被引:1,自引:0,他引:1
探讨了左旋发球的可行性及其方法,指出了它是我国网球运动员追求发球多变性,以弥补力量与速度不足的重要方法之一。同时,也对右上旋发球的技术动作实质和它的随挥方向进行了解析。 相似文献
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3D动漫大片《极速蜗牛》是一部充满了励志和搞笑的电影,一只慢吞吞的花园蜗牛(garden snail)热爱速度,怀着这份逆天的理想,它开始了冒险之旅……奇遇之后,它还真获得了"超级速度"!不过,真实的蜗牛到底能跑多快,运动能力有多强呢? 相似文献
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清代经学大师江永的西学研究已引起学界广泛关注,但对于其西学研究中的理学背景,关注尚有不足。本文以江永《翼梅》中若干西方宇宙论问题为例,分析了传统理气在江永西学研究中的应用及意义。 相似文献