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邓亚君 《记者观察(上半月)》2010,(5):13-15
2008年的汶川大地震中,那些早逝的生命还未来得及从我们的记忆里消逝。“三聚氰胺”就已经成为老百姓对奶粉的第一印象,而一年后,在湖南郴州,数十名孩子因污染而铅中毒;儿童医院用工业氧冒充医用氧;在福建南平,对社会不满的“失败者”直接挥舞屠刀冲向了儿童。 相似文献
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Study on the neurotoxic effects of low-level lead exposure in rats 总被引:10,自引:0,他引:10
Objective: To investigate effects of developmental lead exposure on nitric oxide synthase (NOS) activity in different brain regions and on N-methyl-D-aspartate (NMDA) receptor mRNA expression in the hippocampus of rats. On the basis of these observations, we explored possible mechanisms by which lead exposure leads to impaired learning and memorizing abilities in children. Methods: A series of rat animal models exposed to low levels of lead during the developing period was established (drinking water containing 0.025%, 0.05% and 0.075% lead acetate). NOS activities in the hippocampus, the cerebral cortex, the cerebellum and the brain stem were determined with fluorescence measurement and levels of mRNA expression of the NMDA receptor 2A (NR2A) subunit and NMDA receptor 2B (NR2B) subunit in the rat hippocampus were measured with Retro-translation (RT-PCR). Results: There were no differences in the body weight of rat pups between any of the groups at any given time (P>0.05). The blood lead level of Pb-exposed rat pups showed a systematic pattern of change: at 14 d of age, it was lower than that at 7 d of age, then rising to the peak level at 21 d and finally falling to lower levels at 28 d. The hippocampal NOS activities of lead-exposed groups were all lower than that of the control group on the 21st and 28th day (P<0.01). NOS activities in the cerebellum of lead-exposed groups were all lower than that of the control group on the 21st and 28th day (P<0.001) and the NOS activity of the 0.025% group was significantly lower than that of the 0.05% and 0.075% groups on the 28th day (P<0.05). NOS activity in the cerebral cortex of the 0.075% group was significantly lower than that of the control, 0.025% and 0.05% groups on the four day spans (P<0.001). There was no significant difference of NOS activity in the brain stem between any lead-exposed group and the control group on the four day spans. In the 0.05% and the 0.075% groups, the level of NR2A mRNA expression was higher than that in the control group at 7 d and 14 d of age (P<0.05). In the 0.025% group, the level of NR2A was found to be higher than that in the control group at 7 d of age only (P<0.05). No significant differences were found for the levels of NR2B mRNA expression between any of the groups at any given time. Conclusions: NOS activity in the hippocampus, the cerebral cortex and the cerebellum are inhibited by lead exposure. The degree of the inhibitory effect depends on the time span of exposure and the lead concentration. Developmental low-level lead exposure was found to raise the level of NR2A mRNA expression in the hippocampus of rats. Developmental low-level lead exposure does not affect the level of NR2B mRNA expression in the hippocampus. 相似文献
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《高等教育与学术研究》2008,(4)
本文综述了近年来铅对日常生活的污染和危害,对目前市场上排铅产品的缺失做出了分析,并对富硒多肽作为新型排铅产品的可行性做了肯定,富硒多肽更有效安全,并能深入更小的靶部位作用,有良好的开发前景。 相似文献
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[目的]了解儿童血铅水平及其影响因素。[方法]采用全血锌原卟啉值测定;问卷调查影响儿童血铅水平的相关因素,并进行多元逐步回归分析。[结果]3621名儿童平均血铅浓度为0.504umol/L。超过0.483umol/L共有1615人,占44.6%,多元逐步回归分析表明饭前不洗手、常玩金属或带油漆的玩具、使用含铅量高的学习和生活用具、常吃含铅量高食品、父母吸烟等因素与儿童血铅水平密切相关。[结论]儿童血铅含量水平与不良的生活习惯及生活环境的铅污染有关,应对影响儿童血铅水平的危险因素进行有效的预防。 相似文献