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排序方式: 共有163条查询结果,搜索用时 31 毫秒
31.
Sarama Saha Chandan Sarkar Subhash Chandra Biswas R. Karim 《Indian journal of clinical biochemistry : IJCB》2008,23(3):262-266
Abnormal lipid profile is often found in women with Polycystic Ovary Syndrome. To assess the impact of abnormal lipid profile
on atherosclerosis in young Polycystic Ovary Syndrome women, carotid intima-media thickness as judged by B-mode ultrasonography
were done in 30 young (18–35 yrs) Polycystic Ovary Syndrome women and in similarly age-matched 30 apparently healthy controls.
Compared to controls, young Polycystic Ovary Syndrome women had significantly elevated serum total cholesterol, triglyceride
and LDL-C levels and carotid intima-media thickness. HDL-C level did not differ significantly between two groups of women.
In Polycystic Ovary Syndrome women carotid intima-media thickness was positively correlated with serum total cholesterol,
triglyceride and LDL-C and negatively correlated with serum HDL-C. Our study suggests that even young Polycystic Ovary Syndrome
women are prone to atherosclerosis from early age. 相似文献
32.
Benedicta D’Souza Vivian D’Souza S. Sowmya G. Seema C. N. Hemalatha M. Anu G. Sajana 《Indian journal of clinical biochemistry : IJCB》2008,23(3):218-222
The study was conducted to find out the extent of lipid peroxidation and antioxidant status in ischemic stroke patients (ISPs)
with and without diabetes. Malondialdehyde (MDA) was studied as a marker of lipid peroxidation. Glutathione (GSH), uric acid
and ceruloplasmin were estimated to study the antioxidant potential of ISPs. Significantly higher levels of MDA were found
in both the groups of ISPs and the increase in MDA was more in ISPs without diabetes. GSH levels were decreased significantly
in both the groups of ISPs and maximum decline was found in ISPs with diabetes. Uric acid levels were significantly increased
in both the groups of ISPs. Ceruloplasmin levels were increased significantly in ISPs without diabetes, whereas its levels
were slightly decreased in ISPs with diabetes. A negative correlation was found between MDA and the antioxidants GSH, uric
acid and ceruloplasmin in ISPs with diabetes. This study suggests that there is an association between ischemic stroke and
increased oxidative stress and the antioxidant potential is impaired in both the groups of ISPs with and without diabetes. 相似文献
33.
Gbenga Adebola Adenuga Olusegun Lateef Adebayo Bukunola Oluyemisi Adegbesan 《Indian journal of clinical biochemistry : IJCB》2008,23(1):29-32
The response of liver lipid peroxidative and antioxidant defense system of protein undernourished rats to liver regeneration
induced by partial hepatectomy was examined in rats. Animals were divided into four groups; A,B,C and D of four animals each.
Animals in group A were maintained on 16% casein diet while those in groups B, C and D were placed on low-protein diet (5%
casein) for fourteen weeks and fed ad libitum. 72 hours before sacrifice, partial hepatectomy was carried out on animals in
group D while animals in group C were sham-operated. The results show that protein undernutrition induced an increase in lipid
peroxidation but reduced catalase activity, glutathione level and superoxide dismutase activity when compared with well-nourished
rats. Liver regeneration however, resulted in significant increases in lipid peroxidation and catalase activity but significant
reductions in glutathione level and superoxide dismutase activity in protein undernutrition rats when compared with their
sham-operated counterparts. These results suggest that liver regeneration induced by partial hepatectomy exacerbates lipid
peroxidation in protein undernutrition rats and that Catalase plays a major role in the mopping up of reactive oxygen species
generated following liver regeneration in partially hepatectomised protein undernutrition rats. 相似文献
34.
35.
短裙竹荪 [Dictyophora duplicata(Bose) Fisher]经热水抽提 ,乙醇沉淀 ,Sevag法去蛋白 ,乙醇分级分离 ,再经 DEAE-纤维素柱层析得多糖组分 PS.在体外产生 O·2 的反应体系中 ,竹荪多糖组分 PS在较低浓度下 (<2 0 0 mg/ L)具有清除 O·2 的作用 ,而在较高浓度下 (>2 0 0 mg/ L)作用不明显 .同时用荧光法研究了竹荪多糖组分 PS对人红细胞膜脂质过氧化的影响 ,结果表明竹荪多糖能够抑制人红细胞膜的脂质过氧化 相似文献
36.
杂交水稻叶片衰老与膜脂过氧化作用的关系 总被引:9,自引:0,他引:9
杂交水稻汕优63主茎在抽穗后10d,其叶片自上而下表现出叶绿素和蛋白质含量下降.光合作用速率降低.丙二醇和脂质红过氧化物含量明显增加.SOD活性则为倒三叶>倒四叶>倒二叶>旗叶.实验结果表明:叶片自下而上顺序衰老.叶片衰老与膜脂过氧化作用密切相关. 相似文献
37.
M. Smita K. Naidu A. N. Suryakar Sanjay C. Swami R. V. Katkam K. M. Kumbar 《Indian journal of clinical biochemistry : IJCB》2007,22(2):140-144
Cervical cancer (CaCx) is a global public health problem as it is the second most common cancer leading to the death of women
worldwide. Many references revealed that the low levels of antioxidants induce the generation of free radicals leading to
DNA damage and further mutations. In the present study attempt have been made to evaluate the levels of serum Lipid peroxide,
Nitric Oxide (NO.) Erythrocytic—Superoxide Dismutase (RBC-SOD), Vitamin-C, serum Copper (Cu) and serum Zinc (Zn). 120 patients were divided
in 4 groups according to the increasing CaCx stages i.e. stage I, II, III & IV respectively. All the patients were around
the age group of 25–65 years. 30 healthy women between the same age group were treated as controls. Highly significant increased
values of MDA, NO. and Cu were observed (p<0.001) whereas the activity of RBC-SOD, levels of Vitamin-C and Zn were significantly decreased in
CaCx patients as compared with healthy controls (p<0.001). Cu/Zn ratio was found to be altered in CaCx patients. From our
findings it can be concluded that the oxidative stress is induced among CaCx patients, which inturn increases the risk of
CaCx. 相似文献
38.
Vasavidevi V. Bet Kishor H. Deshpande Adinath N. Suryakar Rajesh D. Ankush Raghavendra V. Katkam 《Indian journal of clinical biochemistry : IJCB》2006,21(2):177-180
Crystal aggregation and retention are critical events for the formation of kidney stones. There is a close association between
crystal development and free radical activity in vivo. In the present study 30 subjects presenting with urolithiasis were
included. Serum levels of total lipid peroxides, nitric oxide (as nitrite), α-tocopherol, plasma ascorbic acid (vitamin C)
and erythrocyte superoxide dismutase activity were measured. These findings were compared with 30 age matched control subjects
irrespective of sex. Student's ‘t’ test was applied for statistical analysis. There was a significant increase in lipid peroxides
(p<0.001), where as significant decrease in nitrite (p<0.01) and α-tocopherol (p<0.001) levels were observed. Plasma ascorbate
(p>0.05) and erythrocyte superoxide dismutase activity (p>0.05) was also found to be decreased but the difference was not
statistically significant which suggests that oxidative stress is evident in urolithiasis with depletion in antioxidant status
where as decrease in nitric oxide may be less abetting in disease condition. 相似文献
39.
Zhuo-mei Chen Ying-xu Chen Guo-jian Du Xi-lin Wu Feng Li 《Journal of Zhejiang University. Science. B》2010,11(3):190-199
Objective:To study the oxidative stress and antioxidative response of Cinnamomum camphora seedlings exposed to nitrogen dioxide (NO2) fumigation.Methods:Measurements were made up of the growth,chlorophyll content,chlorophyll fluorescence,antioxidant system and lipid peroxidation of one-year-old C.camphora seedlings exposed to NO2 (0.1,0.5,and 4 μl/L) fumigation in open top chambers over a period of 60 d.Results:After the first 30 d,0.5 and 4.0 μl/L NO2 showed insignificant effects on the growth of C.camphora seedlings.However,exposure to 0.5 and 4.0 μl/L NO2 for 15 d significantly reduced their chlorophyll content (P0.05),enhanced their malondialdehyde (MDA) content and superoxide dismutase (SOD) activity (P0.05),and also significantly reduced the maximal quantum yield of PSII in the dark [the ratio of variable fluorescence to maximal fluorescence (Fv/Fm)] (P0.05).In the latter 30 d,0.5 μl/L NO2 showed a positive effect on the vitality of the seedlings,which was reflected by a recovery in the ratio of Fv/Fm and chlorophyll content,and obviously enhanced growth,SOD activity,ascorbate (AsA) content and glutathione reductase (GR) activity (P0.05);4.0 μl/L NO2 then showed a negative effect,indicated by significant reductions in chlorophyll content and the ratio of Fv/Fm,and inhibited growth (P0.05).Conclusion:The results suggest adaptation of C.camphora seedlings to 60-d exposure to 0.1 and 0.5 μl/L NO2,but not to 60-d exposure to 4.0 μl/L NO2.C.camphora seedlings may protect themselves from injury by strengthening their antioxidant system in response to NO2-induced oxidative stress. 相似文献
40.
李莲 《孝感职业技术学院学报》2010,13(1):105-109,53
目的:探讨白芍总甙对实验性大鼠酒精性肝损伤的保护作用及其作用机制。方法:SD大鼠随机分为3组:模型组(M组)、生理盐水对照组(N组)、白芍总甙处理组(B组),每组10只。M组大鼠予56°白酒连续灌胃4周制造酒精性肝损伤模型;B组在白酒灌胃基础上给予白芍总甙0.4mg/100g体重灌胃;N组予生理盐水灌胃。第4周末处死大鼠后检测血清ALT、AST、γ-GT、SOD、MDA水平,光镜下观察肝组织细胞形态学改变,用免疫组化方法测定肝细胞核中NF-κB的表达。结果:模型组大鼠血清ALT、AST、γ-GT、MDA水平明显升高;白芍总甙处理组大鼠血清ALT、AST、γ-GT、MDA轻度升高,但明显低于模型组,与生理盐水对照组相比无显著性差异。模型组大鼠血清SOD水平明显降低,白芍总甙处理组与生理盐水对照组血清SOD水平明显高于模型组。模型组肝细胞脂肪变性、坏死、炎性细胞浸润等改变均较白芍总甙处理组及对照组明显。白芍总甙处理组NF-κB的表达低于模型组。结论:白芍能改善肝功能,对实验性大鼠酒精性肝损伤具有保护作用,其机制可能与降低脂质过氧化水平,提高抗氧化酶活性,抑制NF-κB的活化有关。 相似文献