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排序方式: 共有163条查询结果,搜索用时 15 毫秒
91.
Eshrat Halim M. A. Hussain Kaiser Jamil Mala Rao 《Indian journal of clinical biochemistry : IJCB》2001,16(2):190-194
Effect of oral administration of 200 mg/Kg body weight of the aqueous extract ofOcimum sanctum (Tulsi) mixed with diet for eight weeks to diabetic (streptozotocin induced) rats was studied. There was significant reduction
in fasting blood glucose, serum lipid profile, lipid peroxidation products, (LPO) and improvement in glucose tolerance. The
aqueous extract also decreased LPO formation (thiobarbituric acid reactive substances TBARS) and increased antioxidant enzymes
superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione transferase (GT) and one antioxidant
reduced glutathione (GSH) in plasma and rat liver, lung, kidney and brain. The decrease in TBARS and increase in GSH, SOD,
CAT, GPX, and GT clearly shows the antioxidant property ofOcimum sanctum. 相似文献
92.
Anjali C. Warrier Narasimha Y. Rao Devdutta S. Kulpati Tarun K. Mishra Bhaskar C. Kabi 《Indian journal of clinical biochemistry : IJCB》1995,10(1):9-13
There was increase in erythrocyte lipid peroxidation and adenosine deaminase (ADA) activity in red blood cells (RBC's), white
blood cells (WBC's) and plasma, in 30 patients of confirmed diabetes mellitus, 10 each of insulin dependent diabetes mellitus
(IDDM or type I), non-insulin dependent diabetes mellitus (NIDDM or type II) and diabetes with ketoacidosis when compared
with 20 healthy individuals (controls). Glycosylated hemoglobin A1c%, plasma free fatty acid (FFA) and glycerol levels were
also elevated in all the cases when compared with controls. The increase was more in diabetic ketoacidosis group. Significant
positive correlations were seen between erythrocyte lipid peroxidation and ADA activities in RBC's, WBC's and plasma. It is
suggested that decreased tissue adenosine levels due to increase in ADA activity, is related to the severity of hyperglycemia
and lipid peroxidation in diabetes mellitus. 相似文献
93.
成熟的苦瓜种子含水量较高,对脱水的反应既有别于正常性种子,又不同于顽拗性种子.室温下应用不同的方法脱水,虽然脱水速度不同,但都有利于苦瓜种于萌发.当含水量在6%以上时.随含水量降低,种子发芽率,发芽势和活力指数显著提高;超氧物歧化酶(SOD)的活性略有降低,脂氧合酶(LOX)的活性和丙二醛(MDA)含量缓慢上升.当含水量低于6%时,种子发芽率和活力指数下降.SOD活性迅速降低,LOX活性和MDA含量明显增加.温度较高的日晒脱水可显著降低苦瓜种子的发芽率和活力指数.使种子很快死亡;并显著降低SOD和LOX的活性.MDA含量增加明显.室温脱水和6%~9%的含水量有利于苦瓜种子的萌发和活力保持. 相似文献
94.
The objective of the present study was to evaluate hypolipidemic effect of methanolic extract of Celastrus paniculatus in experimentally induced hypercholesterolemic rats. Hypercholesterolemia was induced by feeding the animals with high fat
diet. Oral administration of methanolic seed extract (50%) of Celastrus paniculatus at the optimized dose of 65 mg/kg body weight, substantially reduced the plasma total cholesterol, triglycerides and LDL
cholesterol in comparison with induced hypercholesterolemic animal group and the results were comparable with the standard
hypocholesterolemic drug and almost similar to the control group. Atherogenic index and liver weight of treated animals also
showed significant decrease compared to the hypercholesterolemic animals. It substantially increased the HDL cholesterol level
as compared to control group. A significant increase in the activities of lipoprotein lipase and plasma LCAT enhanced hepatic
bile acid synthesis and thereby, increased degradation of cholesterol to neutral sterols. Furthermore, the activities of HMG-CoA
reductase, glucose 6-phosphate dehydrogenase and malate dehydrogenase were significantly reduced. Histological studies showed
less cholesterol deposits in the aorta of animals fed with seed extract of C. paniculatus compared to the induced hypercholesterolemic animals not given C. paniculatus supplement. 相似文献
95.
Manisha De N. Banerjee G. Talukdar D. K. Bhattacharya 《Indian journal of clinical biochemistry : IJCB》2000,15(1):56-59
The aim of the present work is to understand the effect of low dose of hydroxyurea (HU) therapy on oxidative damage of RBC
membrane in non-transfused Eβ thalassaemia. HU was administered at a dose of 30 mg/kg/day for 90 consecutive days. The percentage
of spectrin and the level of malondialdehyde (MDA), fetal hemoglobin (HbF), hemoglobin (Hb) and packed cell volume (PCV) were
measured. The HbF level was significantly increased after 90 days of HU therapy. MDA level of RBC membrane was decreased.
There was no change in PCV, Hb and spectrin content of RBC membrane after HU therapy for 90 days in Eβ thalassaemia. Increment
of HbF in HU treated Eβ patient may have some role on the correction of oxidative damage of RBC membrane by inhibiting further
degradation of spectrin and by decreasing lipid peroxidation of red cell membrane. 相似文献
96.
In view of several reports that there is a lack of balance in free radicals in case of bronchial asthma (1) the effect of
free radicals on cell membrane was studied by estimating the membrane bound protein Na+, K+-ATPase activity and the intracellular sodium level in patients of bronchial asthma before and after a short course (one week)
of oral corticosteroid (prednisolone 0.75–1mg/kg body weight) therapy. Results showed that there is a definite statistically
significant rise in free radical level and intracellular sodium level and a significant lowering of Na+, K+-ATPase activity in case of untreated bronchial asthma. After short course of therapy with oral corticosteroids, the free
radical level and intracellular sodium level decreased significantly, together with a significant rise of the Na+, K+-ATPase activity. Also, a significant negative correlation (r=−0.74) between the lipid peroxide level and the Na+,-K+-ATPase activity was found in these cases. 相似文献
97.
Vaishali N. Thorat Adinath N. Suryakar Pradeep Naik Bipin M. Tiwale 《Indian journal of clinical biochemistry : IJCB》2009,24(1):102-104
Liver transplantation is an accepted therapy for chronic liver disease patients. These patients generally have low levels
of fat soluble vitamins, which have important antioxidant roles. Therefore, this study was undertaken to investigate whether
such patients had evidence of antioxidant depletion and increased lipid peroxidation before transplant and whether the subsequent
ischemia and reperfusion encountered during liver transplantation have any effect on antioxidant levels and lipid peroxidation.
We assessed plasma total antioxidant capacity and serum lipid peroxide in 12 patients undergoing liver transplantation and
equal numbers of healthy subjects. We found that before reperfusion, antioxidant levels were significantly decreased along
with significantly elevated lipid peroxidation levels as compared with healthy controls (P<0.001). On reperfusion of the liver
graft, further declined values of total antioxidant accompanied with highly elevated lipid peroxidation were seen than those
of pre-reperfusion samples (P<0.001). This data shows that patients undergoing liver transplant have lowered antioxidant defenses
and evidence of free radical damage, which compound the additional insult of reperfusion injury. Therefore antioxidant therapy
in these patients before transplantation may ameliorate the effects of reperfusion. 相似文献
98.
活性氧代谢与植物的抗逆性 总被引:11,自引:0,他引:11
简述了植物体内活性氧的产生及其主要部位,活性氧对膜脂过氧化的启动以及活性氧对细胞膜系统结构的损伤,着重讨论了活性氧的清除与植物的抗逆性之间的关系,认为在各种逆境胁迫下,植物体内酶促与非酶促系统对活性氧的清除从而增强了植物的抗逆性,同时,应用一些外源新型植物生长调节剂可有效促进酶促系统清除活性氧,更好地增强植物对逆境的忍耐力。 相似文献
99.
R. Giri M. M. Kesavulu B. Kameswara Rao V. Ramana Ch. Appa Rao 《Indian journal of clinical biochemistry : IJCB》1999,14(2):168-175
Plasma levels of lipids, lipoproteins and lipid peroxides and erythrocyte Na+−K+ ATPase, Mg2+ATPase and antioxidant enzymes were measured in type-2 diabetic patients. A significant decrease in Na+-K+-ATPase activity was observed in diabetic patients which was negatively correlated with blood glucose and lipid peroxides,
while the Mg2+-ATPase activity was increased. In the diabetic subjects the plasma concentrations of Na+ and K+ were increased where as erythrocyte levels of Na+ were increased and K+ were decreased. Hyperlipidaemia and increased levels of lipid peroxides were observed in the diabetic subjects. There was
a significant increase in erythrocyte catalase activity in diabetics which positively correlated with their lipid peroxides.
There was no change in GPx activities between controls and diabetics. 相似文献
100.
Anitha Devanath Somdattaa Ray Ravi Kumar B. S. Prarthana 《Indian journal of clinical biochemistry : IJCB》2014,29(1):45-50
HIV infection is associated with lipid abnormalities in treatment naïve patients. CD4 count is used for monitoring the HIV infection. Primary objective was to evaluate and correlate lipid profile and CD4 counts in HIV infection. Secondary objective was to evaluate the feasibility of using Lipid profile to monitor the HIV infected treatment naïve patients instead of CD4 counts. 112 patients were selected based on a criteria from ART center in tertiary care center. CD4 counts were assessed and Lipid profile was evaluated enzymatically. A correlation study was done between the lipid profile and the CD4 count and clinical stages of infection. Cholesterol showed no significant correlation in any stage. HDL-C showed significant correlation (p < 0.05) with stage 2 and 4 disease. LDL-C showed no significant correlation in any stage. TGL showed significant correlation (p < 0.05) at stage 4 disease. Hence, HDL-C and TGL can be used as indicators of lipid status and for infection progression in treatment naive HIV patients, while Cholesterol and LDL-C has no role to play. 相似文献