不同运动负荷对血清过氧化脂质、血尿素的影响及与疲劳出现的关系

采用ＴＢＡ荧光沉淀分析并结合临床观察，对１３８名优秀竞技运动员大负荷训练课前后，冬训不同阶段；大负荷一周、二周、三周及主诉疲劳者的血清过氧化脂质、血尿素的变化进行研究。研究表明，不同方式大负荷后过氧化脂质和血尿素明显升高；运动员出现疲劳的程度不一；冬训中后期，机体自由基和过氧化脂质明显升高是造成器官受损和出现疲劳的重要因素，补充抗氧化药物是非常重要的恢复手段；９３０型荧光光度计适用于过氧化脂质的测定。提示，过氧化脂质、血尿素的变化可做为疲劳出现、过度训练的一项生化诊断指标。     

不同强度有氧运动对青年学生血脂的影响

适宜的有氧运动,可以改善血脂蛋白水平,对预防和治疗心血管疾病具有积极作用.从不同强度的有氧运动入手,探讨其对青年学生血脂水平的影响,并就青年学生适宜的有氧运动的强度和方法提出较为具体的建议.     

运动时大学生血浆脂质过氧化物和血液抗氧化系统的变化

本文报导了运动后即刻及恢复期中血浆脂质过氧化物(MDA),血液多种抗氧化酶活性及抗氧化物浓度的变化,及血浆肌酸激酶(CK)、乳酸脱氢酶(DH)、肌红蛋白(Mb)的变化。动态观察表明,运动诱发的自由基反应可以使人体产生一定程度的组织细胞损伤,抗氧化机制具有一定的防护作用。     

体育锻炼对老年人血清某些微量元素和脂质代谢的影响

对60名不同身体状况老年人的血清Zn、Cu等微量元素和TC、Ch、HDL、LDL等的测定结果表明,高血脂症患者血清Zn/Cu比值明显升高,而血浆HDL/Ch比值、HDL/LDL比值明显下降;长期坚持体育锻炼,可使血清某些微量元素、血浆脂质和脂蛋白向有益于机体健康的方向转化,这对防止或减轻AS的发生和发展有积极作用。     

肥胖相关基因的生物信息学研究

目的:筛选肥胖易感基因,探讨基因对肥胖形成的影响以及肥胖的分子机制.方法:利用美国生物技术信息中心(NCBI)、欧洲生物信息研究所(EBI)及其他公共数据库对肥胖相关基因进行检索,根据基因分子功能的不同,筛选出直接调控脂代谢的肥胖基因作为候选基因进行分析讨论.结果:筛选出与肥胖相关的基因总共233个,根据不同功能分类,直接参与脂肪的生成与分解的基因有11个,其余的基因在不同的组织中发挥不同的功能对肥胖进行调控.结论:肥胖是由多基因调控形成的,并没有发现肥胖是由单个基因突变造成的,有些基因与基因相互作用,共同控制着肥胖的发生,而有些基因与环境因素相互适应影响着肥胖的形成.     

In vitro inhibition of lipid peroxidation in fish by turmeric (Curcuma longa)

The beneficial effects of ∈-3 fatty acids on human health have been well documented. Fish and fish oils are the richest sources of ∈-3 fatty acids. However, due to their high degree of unsaturation, they are highly susceptible to lipid peroxidation. Regular consumption of peroxidised oils may represent a risk factor for the induction and development of atherosclerosis. In view of the above reports, it was considered necessary to study the effects of tumeric on fish lipid peroxidation during standard cooking practices and on time-dependent changes in the peroxidation of fish homogenate. The antioxidant effect of α-tocopherol was also studied to confirm the relevance of the study. The results suggest that turmeric may be considered as a safe, cheap and readily usable antioxidant for food preparations.     

Effect of vitamin E on the platelet xanthine oxidase and lipid peroxidation in the patients of myocardial infarction

Platelets play important role in precipitating ischaemic myocardial syndromes in many ways. One of the consequences of ischaemic diseases is excessive generation of oxygen derived free radicals that have numerous pathophysiological consequences. Platelet pro-oxidant enzyme, xanthine oxidase is one of the sources of generation of free radicals. In the present paper, we report the effect of administration of vitamin E along with aspirin on the levels of platelet xanthine oxidase and extent of free radical mediated damage in the patients reperfused after myocardial infarction. Our findings show that administration of 400 mg. vitamin E for six days along with 80 mg. aspirin has an excellent anti-oxidant effect as evidenced by reduced platelet xanthine oxidase activity and lowering of malondialdehdye (MDA) levels which is an index of the extent of free radical mediated damage.     

Plasma antioxidant vitamins and lipid peroxidation products in pregnancy induced hypertension

It has been suggested that antioxidant systems are impaired in pregnancy induced hypertension and hence patients are exposed to oxidative stress. In order to investigate the relationship between lipid peroxidation and certain antioxidant parameters in blood of pregnancy induced hypertension (PIH) cases, 25 normotensive and 23 PIH samples were studied. In the present study, thiobarbituric acid reactive substances showed a tendency to increase, however the increase remained statistically insignificant. Plasma ascorbic acid level remained unaltered and Vitamin E showed a tendency to increase in the study group. The findings implicate oxidative stress in the disease and cite the biochemical rationale for clinical trials of antioxidants to prevent and treat pregnancy induced hypertension.     

自拟“参田方”治疗高血压病血脂升高的临床疗效观察与研究

目的旨在观察参田方在治疗高血压病血脂升高的疗效。方法将2005年7月到2007年7月岳阳市中医院的内科住院病人中符合高血压病和高血脂症的病人随机分为2组,观察2组病人使用参田方和尼群地平片．不同药物的治疗后血压和血脂的变化结果。结果参田方治疗组的降压效果显著优于对照组,降低高血压病患者血清总胆固醇、甘油三脂显著优于对照组。结论参田方组合治疗高血压病血脂升高疗效可靠,经得起重复。     

Interactions between Macromole cules and Membranes

<正>The Partner Group aims at research on hybrid systems built from two types of soft matter systems:water-soluble polymers and biomimetic membranes.The main goal of the group is to investigate the macromolecule-membrane interactions and their roles in the transformation of lipid bilayers in contact with aqueous polymer solutions.The experimental investigations are