Effects of insulin, glimepiride and combination therapy of insulin and metformin on blood sugar and lipid profile of NIDDM patients

In the present study the efficacies of therapy with insulin, sulphonylurea or insulin + metformin on NIDDM patients are compared. One group which was on a definite dose of insulin therapy, but with uncontrolled diabetes was treated by doubling the insulin dose, a second group whose diabetes was not controlled by glibenclamide was switched over to another sulphonylurea viz; glimepiride and a third group whose diabetes was not controlled by insulin therapy was switched over to a combination therapy with insulin +metformin. After recording their initial blood parameters all the groups were treated as above for 3 months, and the parameters were again determined. The fasting blood sugar and serum lipids of the first group were controlled significantly, but the values were far above normal range. However HDL Cholesterol and atherogenic index were near normal range. In glimepiride treated group, none of the parameters showed any amelioration. In the combined therapy group, control of blood sugar and atherogenic index was more or less the same as for group 1, but hyperlipidemia remained slightly above that of the same. From the findings we can infer that in long term diabetes treatment higher doses of insulin and combined therapy with insulin and metformin may be more beneficial than with low doses of insulin or sulfonyl urea alone     

Hypoadiponectinemia in Obesity: Association with Insulin Resistance

Obesity is risk factor for insulin resistance, diabetes, and other chronic diseases. Adiponectin, an adipose-specific protein with antiatherogenic and antiinflammatory effects, were found to be associated with obesity, type 2 diabetes, and insulin resistance. Our aim to identify possible relationships between circulating adiponectin and obesity as well as obesity related phenotypes. A total of 642, obese and non-obese individuals were included in this cross-sectional study. Hormone and glucose levels were estimated using standard protocols. The adiponectin levels showed a significant decrease with increasing quartiles of insulin resistance index. Subjects in lowest quartile of adiponectin level had a significantly higher risk than those in the highest quartile, with higher body mass index, waist circumference, blood pressure, percentage body fat, fat mass, fasting insulin, insulin resistance index, total cholesterol (p < 0.001), low density lipoprotein–cholesterol (p = 0.001), very low density lipoprotein–cholesterol (p = 0.002), and Triglyceride (p = 0.002). The present study indicates that adiponectin is significantly associated with obesity, insulin resistance and other obesity related phenotypes.     

运动锻炼的阻力--当代中国人"运动缺乏"现象的社会学追问

大多数国人都知道，自己需要更多的体育锻炼。但不幸的是，许多人的这一意识并未最终转化为积极的身体锻炼行为。主要就困扰现代中国人的“运动缺乏”现象和一些流行的观点展开追问。诸如，为什么人们明明知道自己缺乏运动却没有实际改变“究竟是什么妨碍了人们建立积极运动的生活方式？在发达国家（如美国）出现的“运动消极”式的生活方式在我国能否避免？如何使国人建构起积极运动的生活方式？研究认为：当前迫切需要的是对上述问题做出深层次的社会学解释。     

Line‐Fitting with Outliers

This article illustrates a method for fitting straight lines to data that is resistant to outliers and might therefore sometimes be preferred to the customary least squares procedure.     

RC选频射极输出器的分析

本文讨论了一种设有电流移相后并联反馈的射极输出器。它既具有一般射极输出器的特点，又在不使用LC调频回路的情况下具有较好的选频作用。     

抗日战争时期的贵州将士--以102师为例

抗战时期,原属黔军体系的贵州将士,不计前嫌,在共赴国难的意识下,自愿要求上前线杀敌报国。在残酷的战争岁月中,贵州将士服从中央国民政府的调遣,先后参加了国内的多次重要战役和中国远征军赴缅作战。战斗中,贵州将士不怕牺牲,奋勇杀敌,屡立战功,表现出顽强的战斗精神和爱国品质,赢得了友军的尊重和上级的褒奖。     

傅作义集团的特点与中共消灭国民党军队的“三种方式”

傅作义是中国现代史中的著名人物。他领导的军事集团在发展壮大过程中逐渐形成了三个显著特点，即鲜明的地方性，强烈的团结性和对外表现出的相对独立性。解放战争后期，在中共中央提出并胜利实施消灭华北地区国民党军队的“天津方式”，“北平方式”和“绥远方式”的过程中，除了毛泽东和中央军委的正确领导以及人民军队的强大等因素发挥作用外，傅作义集团的上述特点也为“三种方式”的出现提供了客观前提。     

从抗战诗歌看当代诗歌的精神缺失

抗战时期，诗歌创作能紧密联系社会、时代，成为进军的鼓点、号角；今天的诗歌，未能喊出时代的强音，而呈现出空前的玄妙、虚无、错乱，大肆张扬“小我”，从而失去了广大读者远离了社会。     

论瓦窑堡会议与抗日民族统一战线

1935年12月召开的瓦窑堡会议是我党历史上一次至关重要的会议.这次会议确立了"抗日反蒋"的政治路线,解决了遵义会议未能解决的党的政治路线问题.并对党建理论进行了大胆创新,坚决纠正了党内长期存在的左的"唯成分论"思想,从而确保了党在抗日民族统一战线中的领导地位,保证了抗日战争的胜利.     

Calcineurin activity as an indicator of oxidative stress in normal islet cells and insulinoma cells

A comparative study was conducted to evaluate calcineurin activity in normal pancreatic beta cells and insulinoma cells in relation to their oxidative state. In comparison to normal islets, insulinoma cells had enhanced oxidative stress as evidenced by increased content of thiobarbituric acid reactive substances. In addition, diminished activity of calcineurin in insulinoma cells was concomitant with decreased content of reduced glutathione and glutathione peroxidase activity signifying diminished antioxidant status in these cells. Culturing insulinoma cells in presence of the calcineurin inhibitor cyclosporin A resulted in further decrease of calcineurin activity with restoration of glutathione peroxidase but without restoration of reduced glutathione levels. These results indicate that an estimate of oxidative stress in pancreatic islets and insulinoma cells can be obtained by assaying calcineurin activity.