分子伴侣的作用探析

分子伴侣不仅是一大类在蛋白质折叠、组装、复性、转运和降解等方面具有重要功能的蛋白质,随着研究的深入,还发现分子伴侣而且是在病毒感染、DNA复制、转录、抗衰老和信号转导等方面也具有重要的功能,本文对此进行了综述。     

基于建构主义的分子生物学教学探索

基于认知心理学理论,结合建构主义的优势,对传统的分子生物学的教学模式进行改革和探索。由于分子生物学课程体系庞大,知识点繁多且抽象,易使学生对其产生厌倦感,影响学习兴趣。我们通过在教学改革实践中依据课程内容特点,随机选择试点班级进行构建主义教学模式探索,教师采用引导学生进入课程主体,培养学生的主动参与自我构建,增强学生的综合素质的教学模式,使得实验班与对照班相比,在分子生物学的期末考试成绩上有显著提高(P<0.05)。因此,科学、合理的分子生物学教学体系,对培养适应现代生命科学技术发展需求、适应市场发展需要的生物技术创新人才具有重要意义,值得应用和大力推广。     

思维导图在高校生物类分子生物学教学中的应用

思维导图作为一种思维工具和辅助学习工具,通过直观化、发散化和非线性方式来帮助掌握学习内容。在分子生物学教学中使用思维导图,可以帮助学生掌握学习重点,提高学习效率,更有效地训练学生的高级思维技能。     

物理原理与工程实践相结合案例浅析

本文结合中国民航大学物理教学实践项目,介绍应用经典力学方法编写符合实际需要的分子动力学模拟程序的基本思路,同时本文给出了具体的模拟结果,该结果与实验监测相符合,达到了预期的目标。本文表明物理基本原理完全可以通过具体的实践项目跳出课堂走入实际应用。     

Theoretical study of NO adsorbed on the surface of TiO2(110) cluster model

The chemisorption properties of N18O adsorption on TiO2(110) surface were investigated by experimental and theoretical methods. The results of temperature programmed desorption (TPD) indicated that the temperatures of the three desorption peaks of the main N2 molecules were at (low) temperature of 230 K, 450 K, and (high) temperature of 980 K. This meant that N18O decomposed and recombined during the process of N2 desorption after N18O was exposed. Analysis of the stable combination and orbital theory calculation of the surface reaction of NO adsorption on the TiO2(110) cluster model showed that there was clear preference for the Ti-NO orientation.     

苹果中赤霉素生物合成途径研究进展

赤霉素是一类植物内源激素,影响植物的生长和发育．“绿色革命”使一年生作物的产量大幅度提高,人们因此认识到赤霉素在生产中的巨大作用,也使赤霉素的研究得到进一步的加强．随着分子生物学的发展,赤霉素生物合成途径中的基因在拟南芥、烟草、水稻等植物中被逐渐克隆出来．文章介绍了赤霉素的生物合成途径在拟南芥、南瓜等作物中的研究情况以及一些矮化突变体,着重概述了苹果中赤霉素生物合成途径的研究进展,为苹果矮化的分子育种提供理论支持．     

西南地区常春藤炭疽病病原鉴定

为弄清引起云南、贵州和四川3省常春藤炭疽病的病原菌种类,采用单胞分离法对引起3省炭疽病的常春藤病原进行了分离。通过显微形态特征和ITS分子系统学研究表明,常春藤炭疽病病原为常春藤炭疽菌(Colletotrichum trichellum(Fr.)Duke)。     

维格纳表象中的量子波包动力学

在文中,发展了纠缠轨线动力学的一般形式。轨线的运动形式适用于一般的势能系统。使用这种改进的轨线动力学方法计算了一个模型势（三次多项势）的反应几率,所得出的结果与精确的量子计算结果符合的非常好。     

Detection of human papillomavirus in oropharyngeal squamous cell carcinoma

Worldwide there has been a significant increase in the incidence of oropharyngeal squamous cell carcinoma (OPSCC) etiologically attributed to oncogenic human papillomavirus (HPV). Reliable and accurate identification and detection tools are important as the incidence of HPV-related cancer is on the rise. Several HPV detection methods for OPSCC have been developed and each has its own advantages and disadvantages in regard to sensitivity, specificity, and technical difficulty. This review summarizes our current knowledge of molecular methods for detecting HPV in OPSCC, including HPV DNA/RNA polymerase chain reaction (PCR), loop-mediated isothermal amplification (LAMP), p16 immunohistochemistry (IHC), and DNA/RNA in situ hybridization (ISH) assays. This summary may facilitate the selection of a suitable method for detecting HPV infection, and therefore may help in the early diagnosis of HPV-related carcinoma to reduce its mortality, incidence, and morbidity.     

Roles and molecular mechanisms of physical exercise in cancer prevention and treatment

Exercise can enhance motivation to change lifestyle behaviors, improve aerobic fitness, improve physical function, control fatigue, and enhance quality of life. Studies have demonstrated the benefits to be gained from physical exercise, highlighting the importance of popularizing the concept of physical exercise for individuals and making professional exercise-treatment programs available to patients with cancer. However, the correlation between physical exercise and carcinogenesis is easily overlooked, and exercise interventions are not routinely provided to patients with cancer, especially those with advanced cancer. In this article, we present a literature review of the effects of exercise on cancer development and progression and give recent evidence for the type of exercise best suited for different types of cancer and in different disease stages. Moreover, the molecular mechanisms about regulating metabolism and systemic immune function in cancer are summarized and discussed. In conclusion, physical exercise should be considered as an important intervention for preventing and treating cancer and its complications.