The Complicated Symptoms of Sick Buildings

SUMMARY

When the symptoms of a possible sick building syndrome appeared in a library building more than twenty years ago, it was thought that the situation could be easily fixed. Instead, we are still managing a problem building although extensive work has been done and much progress has been made to moderate the physical reactions of staff and building users. Looking after the well being of our staff has been the primary motivation.     

Children's attitudes toward their peers with Down Syndrome in schools in rural Ireland: an exploratory study

Increasingly, children with Down Syndrome are attending mainstream schools, but evidence suggests that these children are more prone to peer rejection and other problems when compared with their non‐disabled counterparts. However, relatively little is known about children's attitudes toward their peers with moderate to serious learning disabilities, including Down Syndrome. This study assessed the attitudes of non‐disabled primary school children (n = 118) in mainstream education toward their peers with Down Syndrome. A secondary aim was to assess whether exposure to audiovisual material promoting inclusion had any immediate effects on overall attitudes. A cross‐sectional, questionnaire‐based survey was administered in four rural‐based schools. The results showed that female participants over 10 were the most sociable. Overall attitudes toward inclusion were consistently and statistically significantly more negative than those toward sociability. Other factors, such as contact with peers with Down Syndrome, were not related to attitudes. Neither was there any change in overall attitudes following exposure to the promotional material. Further work is needed to identify factors underpinning the attitudes of non‐disabled children to their peers with Down Syndrome and how best to promote inclusion in mainstream schools.     

Correlation between serum lipid profile and carotid intima-media thickness in Polycystic Ovarian Syndrome

Abnormal lipid profile is often found in women with Polycystic Ovary Syndrome. To assess the impact of abnormal lipid profile on atherosclerosis in young Polycystic Ovary Syndrome women, carotid intima-media thickness as judged by B-mode ultrasonography were done in 30 young (18–35 yrs) Polycystic Ovary Syndrome women and in similarly age-matched 30 apparently healthy controls. Compared to controls, young Polycystic Ovary Syndrome women had significantly elevated serum total cholesterol, triglyceride and LDL-C levels and carotid intima-media thickness. HDL-C level did not differ significantly between two groups of women. In Polycystic Ovary Syndrome women carotid intima-media thickness was positively correlated with serum total cholesterol, triglyceride and LDL-C and negatively correlated with serum HDL-C. Our study suggests that even young Polycystic Ovary Syndrome women are prone to atherosclerosis from early age.     

WILSONLINE

No abstract available for this article.     

高血压中医证型与血液指标的相关性研究进展

近些年来关于高血压中医证型与客观血液生化指标的相关性研究广泛开展并已取得一些进展,血液指标能反映出高血压中医辨证分型的分布规律,文章就高血压中医证型与血液指标的相关性研究作一综述,但由于采用的证型缺乏统一性,与高血压发病密切相关的一些血液指标与中医证型相关性研究仍缺乏可比性。     

阳虚症的生理探讨

阳虚症是中医辩证论治的症型之一，历代历版中医著作（教材）对阳虚症的病因病理从中医的角度阐述较祥，而对其生理现象剖析甚微，本文拟从病症生理、病案生理、治疗用药生理等三个方面试用现代医学之能量代谢原理作一新的探讨。     

The Curious Incidence of Novels About Asperger's Syndrome

Since Asperger's Syndrome was formally recognised in 1994, several novels featuring characters with the syndrome have appeared. Bill Greenwell's article discusses these books in providing a context for a closer consideration of the British publishing sensation of 2003, Mark Haddon's The Curious Incident of the Dog in the Night-Time. The reasons for the success of this suburban comedy, Greenwell argues, include the consequences for the reader of Haddon's choice of the sufferer from Asperger's as narrator, especially the generation of unconscious humour and the range of literary forms he uses to tell his story. Nicholas Tucker adds an Afterword from his perspective as an educational psychologist as well as a literary critic, finding in the novel a rich mixture of heroism, mystery and love mediated through narrrative ingenuity.     

Application of a recombinant replicase to localize the Trionyx sinensis hemorrhagic syndrome virus and evaluate its effects on antiviral genes of T. sinensis

Trionyx sinensis Hemorrhagic Syndrome Virus(TSHSV) is an arterivirus newly discovered in Chinese softshell turtles. Little is known about the effect of antibodies against the virus or the distribution of the virus in different organs of infected turtles. In this study, a partial protein of TSHSV-HP4 was produced using a prokaryotic expression system, and its polyclonal antibody was generated. The polyclonal antibody was confirmed by western blot and dot enzyme-linked immunosorbent assay(dot-ELISA). The distribution of TSHSV in different organs of T. sinensis was examined by immunohistochemistry(IHC) and the expression of immune-related genes was analyzed using quantitative real-time polymerase chain reaction(qRT-PCR). The results indicated that the recombinant TSHSV-HP4 protein was successfully expressed, and the generated polyclonal antibody showed specific binding to viral particles in the lung tissues of infected turtles. The IHC assay indicated that the virus was highly localized in various cells, including intestinal lymphocytes,enterocytes, kidney epithelial cells, spleen cells, lung macrophages, and cardiomyocytes. The qRT-PCR analysis revealed that TSHSV was detected in all organs tested, including the lungs, liver, kidneys, spleen, and heart. The numbers of viral mRNA copies in lung and heart tissues were significantly higher in the virus-antibody group than in the virus group. The interferonstimulated genes(ISGs), myxovirus resistance protein 2(MX2) and radical S-adenosyl methionine domain containing 2(RSAD2) were highly upregulated in all groups of infected turtles. Antibody-dependent enhancement(ADE) seemed to occur after stimulation by the polyclonal antibody, because significantly greater expression of the two genes was detected in the virus-antibody group than in the virus group. Overall, these results are important in understanding the cell localization of TSHSV and the immune response of infected turtles.     

一个伴有夹腿综合症唐氏女生的个案研究报告

本文通过分析一个9岁伴有夹腿综合症的唐氏女生的教育康复过程,探讨对伴有夹腿综合症的智能障碍儿童进行教育训练的可行性方法,并为此类儿童的康复提出有针对性的建议。     

老年急性冠脉综合征79例临床分析

目的:探讨老年急性冠脉综合征的临床特点,为临床诊治该病提供参考依据。方法:收集2003～2007年79例老年急性冠脉综合征患者,74例老年稳定性心绞痛患者临床资料,比较两组的基线情况。结果:老年急性冠脉综合征组并存高血压、糖尿病、脑梗死,高FG、高hs-CRP者与老年稳定性心绞痛组比较明显增多,血脂明显升高;心律失常的严重程度明显增高,心功能不良程度明显加重。结论:高血压、糖尿病、脑血管病,高FG、高hs-CR、高血脂症及心律失常等与老年急性冠脉综合征密切相关,临床诊治该病应考虑其易患因素,早期诊断和及时治疗,可降低患者的病死率。