乙二醇壳聚糖接枝羧甲基β-环糊精用于运载疏水性抗癌药物甲氨蝶呤

利用简单的交联反应合成乙二醇壳聚糖接枝羧甲基β-环糊精(GCH-g-CM β-CD),通过红外光谱、核磁共振谱和浓硫酸-苯酚降解法对其进行表征.将GCH-g-CM β-CD用于运载疏水性抗癌药物甲氨蝶呤(MTX),应用表面等离子体激元共振仪在线原位监测其与MTX的结合,紫外吸收分光光度法测定主客体分子的结合比为1:1.证明GCH-g-CM β-CD通过CM β-CD的疏水空腔与MTX结合,形成稳定的水溶性复合物.因此,GCH-g-CM β-CD有望用于疏水性抗肿瘤药物的运载.     

一种降低复杂度的迭代载波同步算法

针对低信噪比环境下编码辅助载波同步算法存在复杂度高和实时性差的问题, 本工作引入估计积分器不断补偿信号向量、减小待估偏移值. 在此基础上,提出新的同步迭代停止准则;当LDPC码的各变量节点的对数似然比绝对值的均值趋于稳定时,提前停止迭代. 仿真结果表明,该算法在缩小频率搜索范围的同时,大大减少同步迭代次数,且与理想同步译码相比,性能损失不超过0.12 dB.     

环糊精固载量不同的壳聚糖药物载体合成及性能

以乙二醇壳聚糖(GCS)为母体,通过控制交联反应条件,合成固载不同数量羧甲基β环糊精(CMβ-CD)的壳聚糖-环糊精结合物(GCS_n-CMβ-CD).用核磁共振、浓硫酸-苯酚降解法等对结合物进行表征.以5-氟尿嘧啶为模型药物,用表面等离子体激元共振仪在线检测不同结合物与药物的作用.结果表明,不同结合物对药物的运载能力随环糊精数量的增加而增强,对药物的吸附规律符合Langmuir等温方程.为GCS_n-CMβ-CD作为药物载体的进一步应用提供了依据.     

Hydrodynamics and oxygen transfer in a novel extra-loop fluidized bed bioreactor

In this paper, the characteristics of fluid mixing time in a novel extra-loop fluidized bed were studied. The results showed that the mixing time was shortened with the increase of fluid velocity. All the discrete numbers of the reactor were above 0.2. The serial number n was 2.5 -3.0. It was judged accordingly that the reactor fluid state was continous stirred tank reactor （CSTR） mainly. When the inspiratory capacity increased the mixing time of the reactor was shortened. Thus the air input was beneficial for the fluid mixing. During the three phases mixing process, the mixing time of the reactor could be decreased by the n increase of carrier and air loading together, but the change was not significant. The parameters affecting the reactor fluid state were fluid velocity, inspiratory capacity and carrier. KLa could be increased with the air loading increase, and at the same gas/liquid ratio when the pressure drop was high, KL~ value was increased. The amount of carrier complex influence on KLa. As the carrier loading continued to increase, its value had been dropped but the changes was not significant, and optimization condition was found at above 800 1 000 g carrier loading （pouzzolane） or 600 g PVC. Under gas/liquid ratio of 0.8% -5.2%, KLa was （0.62-1.37）×10^-2· s^-1.     

Simulation of dual transponder carrier ranging measurements

The most dominant error source for microwave ranging is the frequency instability of the oscillator that generates the carrier phase signal. The oscillator noise is very difficult to filter due to its extremely low frequency. A dual transponder carrier ranging method can effectively minimize the oscillator noise by combing the reference phase and the to-and-fro measurement phase from the same single oscillator. This method does not require an accurate time tagging system, since it extracts phases on the same satellite. This paper analyzes the dual transponder carrier ranging system by simulation of the phase measurements with comprehensive error models. Both frequency domain and time domain noise transfer characteristics were simulated to compare them with dual one-way ranging. The simulation results in the two domains conformed to each other and demonstrated that a high level of accuracy can also be achieved by use of the dual transponder carder ranging system, with relatively simple instruments.     

大学新生社会实践活动的原则与载体

大学新生社会实践活动必须紧紧围绕中心工作,切实融入到高校人才培养的过程中,不能仅为“活动”而“活动”。在具体工作中,一方面常规载体不能丢,另一方面,要精心设计,创新出能践行整体教育思路的有效载体。     

基于网络载体的高校学生工作平台的构建与思考

随着网络信息化的不断发展,网络日益受到大学生的青睐,成为日常交流的重要工具。利用现有网络载体构建基于网络载体的高校学生工作平台可有效地开展学生工作,方便快捷地了解学生思想动态,成为学生工作者和学生间良好的沟通交流工具。最后,对该工作平台应用过程中所遇到的问题进行思考,获得两点急需解决的任务。     

山水文化——山水城市的核心精神

山水城市的概念融合了中国传统文化中的多种艺术形式的精神内涵,它应具有中国传统文化中"山水文化"的特征。"山水文化"是由于中华民族对于山水的特殊情感而产生的,表现为多姿多彩的思维形态,其中尤以宗教、哲学、美学三大领域与山水的关系最为密切,并成为了"山水文化"的载体;正确地、全面地理解山水城市的核心精神,有助于构画"天人合一"的新型山水城市。     

论李白诗歌豪放飘逸的风格

豪放飘逸的诗风是李白诗歌的显著特色,他豪放飘逸诗风的形成有其客观基础、思想内核和艺术载体。     

新闻博客:一种全新的信息传播方式

新闻博客作为博客当中的一种形式,已经成为当下一种全新的信息传播载体,并越来越普遍地出现在我们的媒介生活中,甚至在一定意义上改变着新闻报道的方式。于是,对新闻博客进行探讨和研究不仅非常必要,而且相当紧迫。