Hematological Parameters and RBC TBARS Level of Q 10 Supplemented Tribal Sickle Cell Patients: A Hospital Based Study

The study has been undertaken as number of sickle cell patients in Chhattisgarh tribal population is 23.7 %. The Co enzyme Q10 is a strong antioxidant and energy producing compound. The patients were divided into three groups group A homozygous (SS), group B heterozygous (AS) and group C controls for TBARS study. The age group is 10–55 years and 200 mg of CoQ10 was given to A and B groups. The hematological parameters, C reactive protein as well as RBC TBARS level were performed by usual and standard techniques. The results were obtained as 25.37 % increased RBC level in group A and 23.24 % in group B. The increased hemoglobin level was observed as 16.73 % in group A and 10.7 % in group B. In case of WBC it was observed increased 24.38 % in group A and 12.0 % in group B. C-reactive protein was observed 7.8 times decreased in group A and 1.54 times in group B. The RBC TBARS level was also found decreased 48 % in group A and 51 % in group B as compared to group C. During the supplementation of coenzyme Q10 the pain caused by vaso-occlusive events has reduced. This significant increase in hematological parameters as well as decreased C-reactive protein and TBARS level suggest that the Q10 should be included in the diet of sickle cell patients.     

女子摔跤运动员实战训练中的机能监测与分析

本研究通过实战训练方法研究,进一步认识女子摔跤运动员在赛前训练阶段生化指标变化的规律,对国家队赛前训练阶段的重点运动员进行了部分生化指标跟踪研究,旨在为该训练方法科学的运用提供理论依据并推广该训练方法在运动训练中的运用。研究结果发现:世锦赛和奥运会选拔赛比赛即刻血乳酸要高于教学比赛后血乳酸水平,而且奥运会第二次选拔赛后即刻血乳酸水平要显著高于教学比赛各组;6分钟×4组的实战训练对于提高运动员的有氧能力也许是有帮助的。     

运动中的酸碱平衡与碱盐摄入

采用文献资料法对人体酸碱平衡机制进行分析研究,并对碱盐摄入与对运动员成绩的影响进行了探讨,结果认为适当碱盐摄入对提高运动成绩有帮助.     

硅藻土负载磷钨酸催化合成1-苯基-2-吡咯烷酮

以硅藻土为载体,磷钨酸作催化剂,γ-丁内酯和苯胺为原料,采用微波辐射技术合成了1-苯基-2-吡咯烷酮(NPP)．系统考察了催化剂负载量、催化剂用量、微波辐射功率、微波辐射时间、原料摩尔比等因素对反应产率的影响．实验结果表明,硅藻土负载磷钨酸催化剂在NPP的合成中显示良好的催化效果,实验筛选的最佳工艺条件为：磷钨酸负载量17．6％、催化剂用量1．5％(质量分数)、微波功率325W、辐射时间14min、γ-丁内酯与苯胺摩尔比1．0∶1．25．在此条件下NPP产率达96％以上,反应速率提高近10倍．     

Chlorogenic acid prevents acetaminophen-induced liver injury: the involvement of CYP450 metabolic enzymes and some antioxidant signals

Chlorogenic acid (CGA), a polyphenolic compound, is abundant in fruits, dietary vegetables, and some medicinal herbs. This study investigated the prevention of CGA against acetaminophen (AP)-induced hepatotoxicity and its engaged mechanisms. CGA reversed the decreased cell viability induced by AP in L-02 cells in vitro. In addition, CGA reduced the AP-induced increased serum levels of alanine/aspartate aminotransferase (ALT/AST) in vivo. The effect of CGA on cytochrome P450 (CYP) enzymatic (CYP2E1, CYP1A2, and CYP3A4) activities showed that CGA caused very little inhibition on CYP2E1 and CYP1A2 enzymatic activities, but not CYP3A4. The measurement of liver malondialdehyde (MDA), reactive oxygen species (ROS), and glutathione (GSH) levels showed that CGA prevented AP-induced liver oxidative stress injury. Further, CGA increased the AP-induced decreased mRNA expression of peroxiredoxin (Prx) 1, 2, 3, 5, 6, epoxide hydrolase (Ephx) 2, and polymerase (RNA) II (DNA directed) polypeptide K (Polr2k), and nuclear factor erythroid-2-related factor 2 (Nrf2). In summary, CGA ameliorates the AP-induced liver injury probably by slightly inhibiting CYP2E1 and CYP1A2 enzymatic properties. In addition, cellular important antioxidant signals such as Prx1, 2, 3, 5, 6, Ephx2, Polr2k, and Nrf2 also contributed to the protection of CGA against AP-induced oxidative stress injury.     

公开级赛艇优秀男子运动员500m耗时递增负荷测试的实证性研究

目的:是为了证明赛艇运动员常用的500 m耗时递增负荷方案测定个体乳酸阈(IAT)的可行性,并通过与4 mmol/L乳酸阈(AT4)的比较,进一步证明IAT的有效性。方法:以9名优秀男子公开级赛艇运动员为研究对象,实验过程包括一次2 000 m最大功(P-MAX)测试、一次500 m耗时递增负荷测试以及一次6 000 m最大功(P-6 km)测试,测试在ConceptⅡ赛艇测功仪完成。结果:500 m耗时递增负荷测试出现较为理想的乳酸-时间曲线,受试者的IAT全部出现在第4、5级负荷间,血乳酸浓度在运动后5 min低于运动结束即刻;P-IAT显著低于P-AT4(P<0.05),而两者心率间差距更加明显(P<0.01);P-IAT与P-2 km及P-6 km有较强的相关性(r=0.778,P<0.05;r=0.848,P<0.01),而P-AT4未见此相关(P>0.05)。结论:500 m耗时递增负荷测试可作为高水平男子公开级赛艇运动员进行IAT测试的负荷方案,IAT较AT4与训练实践有更为密切的关系。     

不同晶型二氧化锰的制备及其催化过氧化氢分解反应性能

制备了不同晶型的二氧化锰,并研究了不同晶型的二氧化锰对催化过氧化氢分解反应速率的影响.结果表明,β-MnO2(K2CO3)的催化活性最好.温度和用量对β-MnO2(K2CO3)催化分解过氧化氢反应有着明显的影响,随着温度和用量的增加,过氧化氢催化分解的反应速率也不断增加.催化剂的重复使用效果并不理想.     

硫酸法催化合成双酚芴的研究

以98%的浓硫酸作为催化剂合成双酚芴进行研究,分别对催化剂用量、助催化剂用量、反应时间、反应温度、酚酮摩尔比等主要因素对反应的影响,进行了试验,试验结果表明,使用浓硫酸催化合成双酚芴,最优条件下双酚芴的反应收率98.20%。制备双酚芴的最佳工艺条件为:酚酮摩尔比6:1,反应温度45℃,反应时间3h,催化剂浓硫酸用量为8.5mL/0.333mol芴酮,助催化剂β-巯基丙酸用量为0.25mL/0.333mol芴酮。     

环十二烷空气氧化制环十二醇的研究

本实验从工程放大角度出发,着重研究了以偏硼酸为催化剂,反应温度和搅拌速率对环十二烷氧化反应的影响,在搅拌鼓泡釜中,适宜反应温度为160～170℃,搅拌转速1500rpm以上,通空气量100ml/g烷.hr,催化剂用量5％,转化率可达30～32％,选择性达73～89％,总收率80～98％(重量百分比)。     

人体心肺机能第二拐点与某些生理生化指标的关系

通过采用放射免疫分析（ＲＩＡ）和乳酸分析等方法，对２０名优秀运动员的实验研究，探讨人体心肺机能达到第二拐点时，血中环－磷酸腺苷（ｃＡＭＰ）、环磷酸鸟苷（ｃＧＭＰ）、乳酸水平、以及吸氧量（绝对值和相对值）、氧脉博等指标的变化，以初步揭示人体机能第二拐点与某些生理生化指标的关系。实验结果表明：人体机能达第二拐点时，以上指标各参数值均明显高于运动起始时刻的数值（Ｐ＜０．００１）。此刻人体所承受的生理负荷强度已达到无氧阈平均水平以上，机体已由有氧供能为主过渡到无氧代谢占优势。