Combination of Se-methylselenocysteine,D-α-tocopheryl succinate, β-carotene,and L-lysine can prevent cancer metastases using as an adjuvant therapy

ObjectivePrimary tumor treatment through surgical resection and adjuvant therapy has been extensively studied, but there is a lack of effective strategies and drugs for the treatment of tumor metastases. Here, we describe a functional product based on a combination of compounds, which can be used as an adjuvant therapy and has well-known mechanisms for inhibiting cancer metastases, improving anti-cancer treatment, and enhancing immunity and antioxidant capacity. Our designed combination, named MVBL, consists of four inexpensive compounds: L-selenium-methylselenocysteine (MSC), D-‍α‍-tocopheryl succinic acid (VES), β‍-carotene (β‍-Ca), and L-lysine (Lys).MethodsThe effects of MVBL on cell viability, cell cycle, cell apoptosis, cell migration, cell invasion, reactive oxygen species (ROS), and paclitaxel (PTX)-combined treatment were studied in vitro. The inhibition of tumor metastasis, antioxidation, and immune enhancement capacity of MVBL were determined in vivo.ResultsMVBL exhibited higher toxicity to tumor cells than to normal cells. It did not significantly affect the cell cycle of cancer cells, but increased their apoptosis. Wound healing, adhesion, and transwell assays showed that MVBL significantly inhibited tumor cell migration, adhesion, and invasion. MVBL sensitized MDA-MB-231 breast cancer cells to PTX, indicating that it can be used as an adjuvant to enhance the therapeutic effect of chemotherapy drugs. In mice, experimental data showed that MVBL inhibited tumor metastasis, prolonged their survival time, and enhanced their antioxidant capacity and immune function.ConclusionsThis study revealed the roles of MVBL in improving immunity and antioxidation, preventing tumor growth, and inhibiting metastasis in vitro and in vivo. MVBL may be used as an adjuvant drug in cancer therapy for improving the survival and quality of life of cancer patients.     

Transportation of AIE-visualized nanoliposomes is dominated by the protein corona

Liposomes, especially cationic liposomes, are the most common and well-investigated nanocarriers for biomedical applications, such as drug and gene delivery. Like other types of nanomaterials, once liposomes are incubated in a biological milieu, their surface can be immediately cloaked by biological components to form a protein corona, which confers a new ‘biological identity’ and modulates downstream interactions with cells. However, it remains unclear how the protein corona affects the transportation mechanism after liposomes interact with cells. Here, we employed home-made aggregation-induced-emission-visualized nanoliposomes TR4@Lipo as a model to investigate transportation with or without the protein corona by optical imaging techniques. The results show that the protein corona can change the cellular transportation mechanism of TR4@Lipo from energy-independent membrane fusion to energy-dependent endocytosis. The protein corona also modulates the intracellular distribution of loaded cargoes. This knowledge furthers our understanding of bio-nano interactions and is important for the efficient use of cationic liposomes.     

一种基于视频的DEW水印算法

采用差分能量水印(DEW)算法,对视频数字作品进行了数字水印的嵌入、检测和提取研究。实验结果表明,该算法计算简单、速度快、易于实现,视频信号里可编码的数据量大,可以隐藏较多的信息,并且还可以满足水印的实时嵌入和提取。     

校园网防范ARP欺骗攻击

目前ARP欺骗攻击呈现出越来越严重的趋势,已成为导致校园网大面积断网甚至瘫痪的首要原因。本文针对校园网中遭受ARP欺骗攻击,分析了其攻击原理、现象,并提出了切实可行的解决方法和防范策略。     

美国国家科学基金会对融合研究的资助及启示

融合研究是促进科学技术发展的新范式,不仅会促进科学技术取得突破性发展,而且是解决21世纪人类面临宏大挑战的一种重要途径。文章考察了融合研究的内涵和特点,以及美国国家科学基金会(NSF)融合研究的概念;根据NSF十大投入计划和新的战略规划(2018—2022年),指出发展融合研究在NSF中的战略地位;分析NSF支持融合研究的基础和融合项目的特点,并对第一批融合项目的实施作了介绍;总结出NSF支持融合研究可供借鉴的若干结论,并对我国发展融合研究提出若干建议。     

基于波士顿咨询集团矩阵的大学学科规划研究

波士顿咨询集团矩阵是对企业经营的全部产品或者业务组合进行整体分析的一种重要的战略工具。本文分析大学利用波士顿咨询集团矩阵进行学科规划的情况,并且对大学利用波士顿咨询集团矩阵进行学科和专业规划的情况进行评价。     

学生科学探究的自主性辨析

我国基础教育各门课程均强调科学探究,但对科学探究的界定却不甚明了,以致一些研究者片面强调学生与科学家的相似性以及学生的自主探究。通过国际研究发现,受学生认知水平、班额大小和课时等内外因素的影响,学生的科学探究需要在教师指导下进行,其指导程度应根据实际情况进行调整。     

Wiki在大学英语写作教学中的应用与实践

Wiki作为一种面向社群的协作式写作系统越来越受到教育工作者的关注,其对大学英语写作教学改革也有着直接的启示.wiki的开放性和协作性有效地弥补了传统英语写作教学中对作文阅读、反馈与修改等提高性措施方面关注不够的缺陷,实践证明,Wiki与英语写作教学相结合,可以充分发挥读、写、改间的交互性、参与性与合作性,对培养英语的写作能力优势明显.因此本文针对当前大学英语写作教学中存在的问题,提出了Wiki在英语写作教学中的应用模式,并进行了实践教学的总结.     

普适计算中资源发现与交互技术的研究

资源发现与交互技术是普适计算的基础。通过在系统级和应用级分析资源发现与交互技术需要解决的问题,在此基础上对现有的协议进行横向比较分析,包括资源描述、发布、查找、状态质询、选择、交互,以及异构性、安全性、自动配置、QoS等方面。基于比较分析结果提出了目前还没有解决的具体问题。     

考虑碳排放成本的长江铁矿石运输研究

为降低钢铁企业采购和运输铁矿石的综合成本,考虑船型、航速和碳排放等因素,建立长江铁矿石运输的混合整数非线性规划模型。将模型中的非线性项转化为线性项,运用CPLEX求解器求解。针对CPLEX求解中大型规模算例的局限性,引入标准粒子群优化（particle swarm optimization, PSO）算法提高求解精度。针对标准PSO算法容易陷入局部最优的问题,提出一种基于自适应策略的改进PSO算法,动态调整惯性权重,提高算法的收敛性和全局寻优能力。通过数值实验发现,改进后的算法在全局寻优能力和收敛能力上有一定的提高。