通心络胶囊对老年原发性高血压患者左心室肥厚及C反应蛋白的影响

目的：探讨通心络胶囊对老年高血压患者左心室肥厚及C反应蛋白的影响。方法：将90例老年原发性高血压患者随机分成治疗组和对照组,对照组给予厄贝沙坦常规治疗,治疗组在常规治疗基础上加用通心络胶囊,疗程6个月。分别于治疗前和治疗6个月后检测左心室肥厚指标和C反应蛋白（CRP）,并观察患者的血压变化及不良反应。结果：两组治疗后左心室肥厚指标较治疗前均降低,且治疗组疗效优于对照组。对照组治疗后CRP未见明显下降,而治疗组CRP下降明显,与对照组比较有显著性差异（P〈0.05）。不良反应均较少,两者比较无统计学意义。结论：通心络胶囊和厄贝沙坦均能有效改善原发性高血压患者的左心室肥厚,其中通心络胶囊加厄贝沙坦疗效更为明显,且通心络胶囊可有效降低老年高血压患者CRP。     

Uric acid as one of the important factors in multifactorial disorders--facts and controversies

With considering serum concentration of the uric acid in humans we are observing hyperuricemia and possible gout development. Many epidemiological studies have shown the relationship between the uric acid and different disorders such are obesity, metabolic syndrome, hypertension and coronary artery disease. Clinicians and investigators recognized serum uric acid concentration as very important diagnostic and prognostic factor of many multifactorial disorders. This review presented few clinical conditions which are not directly related to uric acid, but the concentrations of uric acid might have a great impact in observing, monitoring, prognosis and therapy of such disorders. Uric acid is recognized as a marker of oxidative stress. Production of the uric acid includes enzyme xanthine oxidase which is involved in producing of radical-oxigen species (ROS). As by-products ROS have a significant role in the increased vascular oxidative stress and might be involved in atherogenesis. Uric acid may inhibit endothelial function by inhibition of nitric oxide-function under conditions of oxidative stress. Down regulation of nitric oxide and induction of endothelial dysfunction might also be involved in pathogenesis of hypertension. The most important and well evidenced is possible predictive role of uric acid in predicting short-term outcome (mortality) in acute myocardial infarction (AMI) patients and stroke. Nephrolithiasis of uric acid origin is significantly more common among patients with the metabolic syndrome and obesity. On contrary to this, uric acid also acts is an "antioxidant", a free radical scavenger and a chelator of transitional metal ions which are converted to poorly reactive forms.     

高血压血管内皮损伤和胰岛素抵抗机制与运动干预的研究进展

通过探讨高血压内皮损伤与胰岛素抵抗的关系,追究运动干预的应用前景。研究方法：采用文献回顾与前瞻性分析及逻辑推理相结合的方法,跟踪高血压内皮损伤与胰岛素抵抗的研究进展及其在运动医学领域中的作用。结论：原发性高血压可以通过炎症因子损伤内皮细胞继而产生胰岛素抵抗,胰岛素抵抗也可以通过内皮细胞损伤引发高血压,而有氧运动干预后,缓解了高血压内皮细胞损伤,进而减轻胰岛素抵抗,缓解高血压的症状。     

Acute pancreatitis associated left-sided portal hypertension with severe gastrointestinal bleeding treated by transcatheter splenic artery embolization: a case report and literature review

Left-sided portal hypertension (LSPH) followed by acute pancreatitis is a rare condition with most patients being asymptomatic. In cases where gastrointestinal (GI) bleeding is present, however, the condition is more complicated and the mortality is very high because of the difficulty in diagnosing and selecting optimal treatment. A successfully treated case with severe GI bleeding by transcatheter splenic artery embolization is reported in this article. The patient exhibited severe uncontrollable GI bleeding and was confirmed as gastric varices secondary to LSPH by enhanced computed tomography (CT) scan and CT-angiography. After embolization, the bleeding stopped and stabilized for the entire follow-up period without any severe complications. In conclusion, embolization of the splenic artery is a simple, safe, and effective method of controlling gastric variceal bleeding caused by LSPH in acute pancreatitis.     

2000年国民体质监测中的成年人和老年人高血压检出人群体质现状分析

本研究利用2000年国民体质监测的资料，对我国17．7万成年人和老年人进行高血压人群的筛选。并在此基础上，分析不同血压类型人群的体质特征，以掌握高血压对体质各方面造成的影响。     

有氧运动防治高血压机制的探讨

有氧运动是抗高血压病非药物疗法的最有效有段,是有效的降压干预措施之一。探讨高血压病的发病机制以及有氧运动对高血压病的影响、降压机制及降压的效果和意义,对提高中国原发性高血治疗的效价比、更好地控制原发性高血压蔓延、预防心脑血管疾病具有现实意义。     

中老年高血压病临床特点的对比观察

本文对45例中老年人高血压病的临床观察,结果表明:老年病人平均收缩压、脉压差均明显高于中青年人;且左心室受累,血脂增高,心脑、肾动脉硬化,合并症多,死亡率高。     

影响原发性高血压患者服药依从性相关因素的调查研究

目的:了解原发性高血压患者服药依从性的情况,探讨影响原发性高血压患者服药依从性的相关因素。方法:采用自制问卷调查巴彦淖尔市地区高血压患者的服药情况并分析相关因素。结果:发放300份问卷,回收有效问卷285份,其中服药依从性好的有91例,服药依从性差的有194例。性别、文化程度与人均月收入对服药依从性的影响具有统计学差异(P<0.05);服药知识的掌握情况与服药依从性呈显著的正相关(r=0.315,P<0.01)。结论:巴彦淖尔市地区原发性高血压患者的服药依从性差,影响服药依从性的因素较多。     

门脉高压征门奇静脉断流术后胃破裂的防治

目的:探讨门奇静脉断流术后胃破裂的原因和防治措施.方法:回顾分析1995.1～2003.2月我院65例门脉高压征行门奇静脉断流术 脾切除术后胃破裂的患者.结果:65例患者中2例患者术后发生胃底破裂,1例经二次开腹修补破裂口痊愈,后因肝功能衰竭死亡,另一例二次术后痊愈出院,随访至今无严重并发症出现.结论:门奇静脉断流术 脾切除术中离断脾胃韧带时尽量靠脾侧切断韧带,近胃侧断端贯穿缝扎并包埋于浆膜腔内,术后持续胃肠减压,同时给予止酸保护胃粘膜药物治疗,可有效防止该并发症的发生.     

Science Letters: Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension

Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease of unknown etiology. The exact pathogenesis of pulmonary arterial hypertension is still not well known. In the past decades, many protein molecules have been found to be involved in the development of IPAH. With proteomic techniques, profiling of human plasma proteome becomes more feasible in searching for disease-related markers. In present study, we showed the protein expression profiles of the serum of IPAH and healthy controls after depleting a few high-abundant proteins in serum. Thirteen spots had changed significantly in IPAH compared with healthy controls and were identified by LC-MS/MS. Alpha-1-antitrypsin and vitronectin were down-regulated in IPAH and may be valuable candidates for further explorations of their roles in the development of IPAH.