武都力治疗盐敏感性高血压性价比的评定

目的:探寻治疗盐敏感性高血压最优性价比的治疗方案。方法:将急性盐水负荷试验筛选出的48例盐敏感性高血压患者随机分为实验组与对照组,实验组服用武都力治疗,对照组采用硝苯地平缓释片加依苏片治疗,治疗8周前后各行ABPM及实验室检查一次,并比较两组治疗方案每天平均药品费用。结果:ABPM显示两组8周末24 h、日间、夜间收缩压/舒张压(SPB/DBP)较治疗前分别下降:实验组(9.2±4.8/5.8±4.2)mmHg、(10.4±6.2/6.6±3.0)mmHg、(6.7±8.7/5.0±7.4)mmHg;对照组(9.4±5.4/6.2±4.1)mmHg、(10.6±6.2/6.7±4.1)mmHg、(6.8±9.1/5.0±7.7)mmHg。两组均无严重不良反应。实验组日均药费0.725元,对照组日均药费3.513元。结论:武都力是治疗盐敏感性高血压性价比较高的药物。     

妊高征患者血清免疫球蛋白及补体C_3的结果分析

目的探讨妊高征患者血清免疫球蛋白(IgG、Ig M、IgA)及补体C_3的变化规律及它们在妊高征发病中的作用。方法对75例妊高征患者(轻度25例,中度30例,重度20例),与正常妊娠组(60例)血清免疫球蛋白和补体C_3进行比较。结果与正常妊娠组比较,血IgG水平在轻、中、重度妊高征组中差异非常显著(P<0.01);血Ig M、IgA水平及补体C_3水平在轻度妊高征组中无显著差异(P>0.05),但在中、重度妊高征组中显著差异(P<0.01)。结论妊高征患者血清免疫球蛋白及补体C_3的浓度均低于正常妊娠组,其生理性免疫功能受到抑制。     

Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension

Idiopathic pulmonary arterial hypertension(IPAH) is a rare disease of unknown etiology.The exact pathogenesis of pulmonary arterial hypertension is still not well known.In the past decades,many protein molecules have been found to be in-volved in the development of IPAH.With proteomic techniques,profiling of human plasma proteome becomes more feasible in searching for disease-related markers.In present study,we showed the protein expression profiles of the serum of IPAH and healthy controls after depleting a few high-abundant proteins in serum.Thirteen spots had changed significantly in IPAH com-pared with healthy controls and were identified by LC-MS/MS.Alpha-1-antitrypsin and vitronectin were down-regulated in IPAH and may be valuable candidates for further explorations of their roles in the development of IPAH.     

原发性高血压与心理社会行为因素

原发性高血压在我国发病率高,但知晓率、治疗率和控制率很低,本文通过探讨心理社会行为因素与原发性高血压之间的关系,深入对原发性高血压的认识,加强防范意识,积极开展一级预防,在药物治疗的基础上重视心理行为治疗,降低高血压的发病率、病死率,使我国的高血压防治工作取得长足进步.     

长期运动训练与原发性高血压降压

目前原发性高血压的运动疗法越来越为人们所重视。本文就长期运动训练对血压的影响、运动训练的降压机制及运动处方的制定原则进行了阐述,旨在为科学有效的制定高血压运动处方提供理论参考。     

一种智能化NO输送系统的研制

为了满足临床吸入一氧化氮（NO）治疗安全与可靠的要求,研制一种和呼吸机同步的一氧化氮吸入装置是至关重要的．该装置使用气体流量计（GFM）检测呼吸机的吸气流量,通过气体稀释公式计算出在治疗条件下NO标气的流量,并由质量流量控制器（MFC）来控制NO标气送往呼吸回路,同时采用NO／NO2电化学传感器对进入人体前的治疗气中NO浓度和二氧化氮（NO2）浓度进行监测．试验结果表明：该一氧化氮吸入装置供N0标气相对于呼吸机供气滞后不到200ms,NO气体的用量相对于持续供气时节约了E／（I＋E）（吸呼比：I：E）、NO2的生成量〈2mg／L,从而不仅实现了监测与配气的智能化,而且也提高了NO治疗气精度、确保了治疗的可靠性与安全性．     

主要营养素对心血管疾病影响的研究进展

营养素（脂肪、维生素、矿物质、蛋白质等）影响着高血压、高血脂、冠心病等心血管疾病.肥胖、甘油三酯（TG）水平与高血压病的发生率密切相关;钠对高血压的作用强度大,钾与钠的比例以及钙的摄入量直接影响血压的高低;维生素C、维生素E可改善高血压患者受损的内皮依赖性血管舒张功能.VitC与VitE、食物纤维具有良好的降低血脂的作用;缺锌可引起血脂代谢异常.高脂肪和高胆固醇能增加冠心病的发病率;VitE具有抗动脉粥样硬化的作用;多钠能促进冠心病的发生,镁能阻止或者延缓动脉粥样硬化的发生及发展.     

血管紧张素原基因CD235Met-Thr变异与高血压脑梗塞发病的相关性

探讨汉族人群血管紧张素原(AGT)基因CD235Met-Thr变异与高血压合并脑梗塞发生的关系.采用突变基因分离聚合酶链反应(MS-PCR)方法检测82例高血压合并脑梗塞患者(BI)、67例单纯高血压患者(EH)和95例健康对照者(C)的M235T等位基因型.BI组AGT基因T/T基因型频率和T等位基因频率(分别为0.720和0.811)显著高于C组(分别为0.516和0.700,P＜0.05)和EH组(分别为0.537和0.716,P＜0.05).结果提示,AGT基因CD235Met-Thr变异增加了汉族人群高血压合并脑梗塞发病的易感性.     

CT demonstration of caput medusae

Maximum intensity and volume rendered CT displays of caput medusae are provided to demonstrate both the anatomy and physiology of this portosystemic shunt associated with portal hypertension. Anat Sci Educ 2:184–185, 2009. © 2009 American Association of Anatomists.     

Comparison of the prevalence and treatment of hypertension in two populations in the United States: Masters swimmers versus the NHANES population

Abstract

This research compares the prevalence of hypertension in a group of adult masters swimmers with an age and sex matched cohort from the 2008 NHANES (National Health and Nutrition Examination Survey), used to represent the general population in the United States. Masters swimmer data were obtained from a one-time survey of all United States Masters Swimming (USMS) members. Both datasets included demographics, drug therapy, diseases and health status. Characteristics of swimming sessions as well as perceptions of impact of medications on exercise were also collected from the USMS respondents. Of 1346 completed surveys from USMS respondents, 15.8% self-identified as having hypertension while 36.2% participants in the NHANES survey suffered from hypertension (P < 0.001). The two groups were well matched for age and gender but the USMS group was primarily Caucasian, higher income, higher education, and reported higher health status. In the USMS group, not only was hypertension less prevalent but those who suffered from hypertension took fewer medications (P = 0.04) to manage their hypertension than in the NHANES group. Additionally, The USMS group suffering from hypertension considered themselves healthier (P < 0.001) than the NHANES group.