循证护理应用于高血压患者的临床观察

目的:观察循证护理实践对高血压患者的影响。方法:就诊高血压病患者随机分成对照组和循证组,在药物治疗基础上,对照组采取传统护理模式,循证组实施循证护理干预,比较两组血压达标率和健康知识掌握及依从性情况。结果:循证组血压控制达标44例(70.9%),对照组27例(50.0%),两组间差异有统计学意义(χ2=5.34,P<0.05);循证组健康知识掌握及依从性均好于对照组,比较差异有统计学意义(P<0.05或P<0.01)。结论:循证护理可提高护理质量,从而使高血压的治疗获得更加满意的效果。     

150例高血压病患者并发症临床观察

目的:探讨单纯收缩期高血压、收缩压与舒张压高血压并发心脑血管病的机率。方法:将150例高血压患者分成3组:52例舒张压升高患者;15例单纯收缩期高血压;54例收缩期、舒张期均高的高血压并发心脑血管病发症的患者进行临床分析。结果:单纯舒张期高血压预后良好,而单纯收缩期高血压及收缩压合并舒张压升高者有较大的发生心脑血管病的危险性。结论:对单纯收缩期高血压、及收缩压合并舒张压升高的患者应给予足够重视,并积极治疗。     

动态血压监测评价武都力对老年高血压的降压疗效

目的：通过动态血压监测(ABPM)，对武都力治疗老年轻中度高血压的疗效进行评价．方法：48例老年高血压患者每天服用武都力一片，在治疗前后分别进行动态血压监测，观察24h的收缩压(SBP)、舒张压(DBP)及降压谷／峰比值(T／P)，并观察治疗前后对代谢的影响。结果：治疗前后24h及白昼、夜间SBP，DBP均有显著下降(P＜0．01)，T／P比值为71％．两组代谢均无明显变化．结论：武都力一次给药治疗老年性高血压，降压平稳且不影响代谢。     

芬太尼和异丙酚在高血压患者胃镜检查中的应用研究

探讨高血压患者应用芬太尼、异丙酚施行镇静无痛苦胃镜检查的安全性及可行性,将112例患者（A组）给予芬太尼-异丙酚镇静麻醉,另外108例患者（B组）常规操作.结果显示A组患者的血压、心率和SDNN均降至正常范围,100%患者认为无痛苦,愿意接受复查,B组血压升高,心率加快,SDNN下降,54.5%患者感觉不适,不愿接受复查.二组患者血氧饱和度检查中无明显变化.高血压患者施行镇静无痛苦胃镜检查是一种安全可行的方法.     

Science Letters： Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension

Idiopathic pulmonary arterial hypertension （IPAH） is a rare disease of unknown etiology. The exact pathogenesis of pulmonary arterial hypertension is still not well known. In the past decades, many protein molecules have been found to be involved in the development of IPAH. With proteomic techniques, profiling of human plasma proteome becomes more feasible in searching for disease-related markers. In present study, we showed the protein expression profiles of the serum of IPAH and healthy controls after depleting a few high-abundant proteins in serum. Thirteen spots had changed significantly in IPAH compared with healthy controls and were identified by LC-MS/MS. Alpha- 1-antitrypsin and vitronectin were down-regulated in IPAH and may be valuable candidates for further explorations of their roles in the development of IPAH.     

单纯收缩期高血压与双期高血压的情绪障碍临床观察

目的：比较单纯收缩期高血压与双期高血压情绪障碍的差异。方法：分别收集老年单纯收缩期高血压及双期高血压患者各100例,治疗前两组病人均用焦虑及抑郁量表评估情绪状态并进行组间比较,同时与正常人的常模比较。结果：两组高血压病人治疗前焦虑及抑郁均值高于常模,尤其是单纯收缩期高血压组与双期高血压相比焦虑指数有显著差异（P〈0.001）。结论：单纯收缩期高血压患者中抑郁及焦虑患病率高,尤其是焦虑障碍明显高于双期高血压,提示临床医师应对其情绪障碍进行有效干预,以提高临床疗效。     

Relationship of “weekend warrior” and regular physical activity patterns with metabolic syndrome and its associated diseases among Chinese rural adults

Little is known about the “weekend warrior” pattern of physical activity (PA) where people perform all their PA in 1 or 2 sessions per week. We investigated the relationship of weekend warrior and other PA patterns with metabolic syndrome (MS) and its associated diseases. Data on sociodemographic and lifestyle characteristics were collected from the Nantong Metabolic Syndrome Study that included 13,505 women and 6,997 men between 2007 and 2008. Compared with inactive participants, weekend warriors were at lower risk of MS, diabetes, and hypertension; respective odds ratios (95% confidence intervals) for men and women were 0.58 (0.43–0.79) and 0.67 (0.52–0.86), 0.52 (0.34–0.79) and 0.52 (0.33–0.83), and 0.79 (0.63–0.99) and 0.71 (0.57–0.89). Similar results were observed with regular activity, at a frequency of >3 sessions per week. Both weekend warrior and regular PA patterns showed a 10–60% decrease in abnormal triglycerides, glucose, and blood pressure in both sexes; abnormal waist circumference in men only; and abnormal high-density lipoprotein in women only. Our observed cross-sectional relationships reflect that >150 min/week of moderate PA or 75 min/week vigorous-intensity PA is needed to prevent MS and its component diseases, even if in a short-bout, intermittent PA pattern.

Abbreviations: MS: Metabolic syndrome; WC: Waist circumference; TG: Triglycerides; HDL-c: High-density lipoprotein cholesterol; BP: Blood pressure; SBP: Systolic blood pressure, DBP: Diastolic blood pressure; PA: Physical activity; JIS: Joint Interim Statement; CVD: Cardiovascular disease; ATP III: US Third Report of the National Cholesterol Education Program, the Adult Treatment Panel; IDF: International Diabetes Federation; IPAQ: International Physical Activity Questionnaire; BMI: Body mass index; CDC: the Nantong Centers for Disease Control; OR: Odds ratio; CI: Confidence interval; SD: Standard deviation; IQR: Interquartile range.     

体力活动和力量训练对血压的影响

采用文献资料法,探讨了体力活动和力量训练对血压的影响,指出身体活动水平的低下与发展高血压的高危险性密切相关,力量训练对休息状态的舒张压有一定的降低作用。     

不同年龄自发性高血压大鼠心肌ATP酶活性变化

目的 :探讨高血压心肌肥厚过程中Na+ -K+ -ATPase活性的变化。方法 :用酶活性测定的方法 ,测定 12周、16周自发性高血压大鼠 (SHR)大鼠和Wistar大鼠的心肌Na+ -K+-ATPase酶的活性。结果 :(1)不同年龄SHR大鼠血压和左心室肥厚指数明显高于同龄Wis tar大鼠 ,但SHR大鼠间无显著差异。 (2 )SHR大鼠心肌Na+ -K+ -ATPase活性随年龄增加而明显降低 ,但两种大鼠 12周龄、16周龄间无显著差异。结论 :SHR大鼠血压和左心室肥厚指数明显增加 ,Na+ -K+ -ATPase活性发生下降 ,但是 12周与 16周间无明显差异。     

压力后负荷增高性高血压大鼠心肌胶原网络重建

目的:观察在高血压不同时期心肌胶原网络的改变,为高血压的治疗及心脏功能的早期保护提供基础资料.方法:用Masson三色法染色、光镜观察和天狼猩红-苦味酸饱和液染色、偏振光显微镜观察两种方法,对压力后负荷增高性高血压大鼠动物模型术后2周、4周、8周心肌胶原进行观察,采用计算机图象分析方法,对高血压不同时期心肌胶原总量和Ⅰ/Ⅲ型胶原比例的改变进行观测.结果:4周时心肌胶原总量较2周时增多,Ⅰ/Ⅲ型胶原量比例无显著改变.8周时,血管周围胶原增生显著,且向周围心肌间质中蔓延,出现了大面积的心肌细胞消失,取而代之为胶原纤维.胶原纤维互相交织,排列杂乱无章.Ⅰ型胶原增多,Ⅰ/Ⅲ型胶原量比例增大.结论:在高血压时,心肌胶原网络重建与血压增速和病程关系密切.血压增高越快,病程越长,胶原网络破坏越严重.