运动训练中补充谷氨酰胺对免疫系统的影响

采用文献资料法,通过研究谷氨酰胺（Gln）在运动训练中的主要生理作用及其对免疫细胞的影响,以及补充外源性Gln在运动免疫中的作用,可进一步探讨运动训练中合理补充Gln对免疫系统的影响,进而提高运动能力。     

穴位刺激对高特质焦虑田径运动员赛前焦虑调控的实验研究

选取上海体育学院14名高特质焦虑男性田径运动员,并对其“足三里”和“三阴交”施加电针穴位刺激,观察在心理应激条件下穴位刺激对运动员机体免疫和焦虑状况的影响,分析运动员机体免疫和焦虑状况之间的关系。通过对实验前后运动员免疫指标（血液T淋巴细胞CD3^＋％、血液辅助性T淋巴细胞亚群TCD4^＋、抑制性T淋巴细胞亚群TCD8^＋、TCD4^＋／CD8^＋％、NK％、NKT％）和心理焦虑指标的测试,为综合分析穴位刺激对高特质焦虑运动员赛前机体免疫和焦虑状况调节的效果和机制提供一定的实验依据。     

强杂波环境下网络病毒传播灰阶菌群免疫算法

网络病毒的入侵和传播通常伴随着强杂波信息的掩盖而提高其生存能力,研究一种有效的免疫算法是对抗病毒传播的关键。传统的抵御网络病毒传播的免疫方法采用人工免疫算法,该法基于熵权重属性分类时不能有效抵抗强杂波干扰的影响,抗病毒感染的免疫能力不高。本文提出一种基于自适应实时繁殖策略的灰阶菌群免疫算法,采用分段匹配白化滤波方法滤除杂波信息,构建强杂波环境下病毒传播数学演化模型,以信息熵作为病毒传播免疫分类属性,提出采用灰阶菌群聚类方法进行病毒特征免疫。进行仿真实验表明该算法能有效滤除病毒潜藏的杂波干扰,病毒信息特征菌群得到准确聚类,降低了计算机用户的感染率,实时性和稳定性好。     

大剂量干扰素治疗重症肝炎疗效观察

在综合治疗基础上加用大剂量人血白细胞干扰素治疗14例慢性重症肝炎,1例亚急性重症肝炎.前7d采用1×10~6UImq8h,以后1×10~6UImqd,总量大于30×10~6U,结果15例中存活10例,占66.7％,存活率比以往综合治疗明显提高.14例乙肝标志物检查结果:HBeAg或抗-HBcIgM有一项阳性者占100％,提示病毒处于复制状态,治疗后HBeAg阴转率为85.7％,抗-HBcIgM阴转率为100％,HBsAg阴转率为12.5％,显示抗病毒效果显著。     

生物多感觉信号变异检测方法研究与仿真

动物不同脑部感官信息在频率、振幅等属性上差异较大,多个差异性较强的单感觉信息进行融合时会发生信号排异冲突,造成转化生成的脑部衰退特征信号强度较弱。提出了一种基于人工免疫算法的生物多感觉信号变异检测方法。建立信号变异特征动态变化方程,获取信号变异特征变异的交叉点分布情况。更新信号变异特征数据库,在数据库中选取信号变异特征。克服了传统算法的弊端。实验证明,这种算法能够避免信号变异特征突变的缺陷,提高了信号变异检测的准确率。     

运动对细胞凋亡的影响(综述)

细胞凋亡(apoptosis)是一种由基因控制的细胞自主性死亡过程，其性质为生理性细胞死亡。细胞凋亡的研究已成为生物医学领域中最热门的课题之一。然而在运动医学中的研究尚不多见，为此就运动对细胞凋亡影响的一些新的研究进展进行了综述。     

对运动后上呼吸道感染发病机理的思考

运动员运动后 ,易患上呼吸道感染疾病 .本文试从运动过程中机体体温的变化特点和机体大强度运动后免疫能力下降两方面 ,对其发病机理进行了分析 ,并提出了可行的预防措施 .     

基于免疫算法的二次曲面几何参数提取

在机械产品的逆向工程中,针对测量数据提取常用二次曲面几何参数非常重要,它有助于理解设计意图,提高重建模型的精度和效率。提出了基于实数编码免疫算法针对离散数据点进行二次曲面提取的方法。数值实验结果证明了此算法的有效性、鲁棒性和精确性。     

Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors (TLRs) plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 (TLR2) ligand, Pam3CSK4, has been reported to modulate the balance of Thl/Tn2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen (HDM). Mice were sensitized and challenged with Dermatophagoides farinae allergen (Der f), and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid (BALF). Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that' IFN-γ released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

Science Letters: A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors (TLRs) plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 (TLR2) ligand, Pam3CSK4, has been reported to modulate the balance of Thl/Tn2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen (HDM). Mice were sensitized and challenged with Dermatophagoides farinae allergen (Der f), and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid (BALF). Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that' IFN-γ released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.