Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors (TLRs) plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 (TLR2) ligand, Pam3CSK4, has been reported to modulate the balance of Thl/Tn2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen (HDM). Mice were sensitized and challenged with Dermatophagoides farinae allergen (Der f), and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid (BALF). Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that' IFN-γ released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

Science Letters: A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors (TLRs) plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 (TLR2) ligand, Pam3CSK4, has been reported to modulate the balance of Thl/Tn2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen (HDM). Mice were sensitized and challenged with Dermatophagoides farinae allergen (Der f), and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid (BALF). Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that' IFN-γ released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

计算机免疫系统中Apriori算法的应用及其改进策略

本文将Apriori算法应用于计算机免疫系统中提取规则,并详细地给出了Apriori算法,同时由于Apriori算法需要频繁扫描数据库,运行效率比较低,从而提出了Apriori算法的三种改进策略：优化连接策略,数据划分策略和减少交易数据策略。     

一种新型免疫遗传算法在图像增强上的应用

将一种新型免疫遗传算法应用到图像的增强处理中,利用其快速搜索能力,对给定测试图像,自适应地变异、搜索、直至最终确定变换函数的最佳参数α,β值,从而实现图像的增强.与穷举法相比,大大节约了求解的时间和计算的复杂度,并通过对自然图像的仿真实验论证该方法的有效性.     

中国神水对大鼠实验性胃溃疡及小鼠免疫功能的影响

中国神水最大耐受量为180ml/kg,按1/18,1/36,1/180设置药效学3个剂量组,中国神水5,10ml/kg可增强小鼠体液免疫功能及吞噬功能,对应急性胃溃疡及灌胃醋酸引起的急性胃炎均有显著抑制作用,中国神水给药30d,未发现明显毒副作用.     

补充枸杞多糖对排球运动员免疫功能的影响

目的:探讨补充枸杞多糖对排球运动员免疫功能的影响。方法实验组和对照组每天进行大强度训练。连续训练30 d。训练期间实验组每天早晚服用枸杞多糖各2.5 g,对照组每天早晚各服安慰剂2.5 g。在实验前后分别检测免疫指标CD3 %、CD4 %、CD8 %、CD4 /CD8 、IgA、IgG和IgM。结果:30 d的大强度训练后,实验组CD3 %、CD4 %、CD4 /CD8 、IgA、IgG较对照组明显升高(P<0.05);CD8 %明显低于对照组(P<0.05)。结论:补充枸杞多糖对排球运动员细胞免疫功能具有改善的作用。     

太极拳运动对Ⅱ型糖尿病患者免疫机能影响的研究

目的观察太极拳运动对Ⅱ型糖尿病患者免疫机能的影响。方法采用自身对照的方法,测定太极拳运动锻炼前后免疫机能的变化。结果太极拳运动后,补体C3、白细胞介素-2(IL-2)明显升高(P<0.05),可溶性白细胞介素-2受体(S-IL-2R)明显下降(P<0.05),淋巴细胞亚群辅助性T细胞CD4 明显升高(P<0.05)、CD4 /CD8 比值无明显变化。结论太极拳运动锻炼有助于提高2型糖尿病患者机体的免疫机能。     

鱼类干扰素系统基因的克隆鉴定及其特征分析(英文)

干扰素(IFN)系统是脊椎动物抵抗病毒入侵的第一道防御系统。除了哺乳类,有关低等脊椎动物的IFN系统基因知之甚少。在鱼类,近40年来能证明IFN系统存在的证据主要有两个：一是检测经病毒诱导后的多种鱼类机体和细胞,证明能产生类似哺乳类IFN的抗病毒活性物质;二是近年来,已经证明在少数几种鱼类中存在与哺乳类IFN系统基因Mx同源的基因。以前的研究结果表明,紫外线灭活的草鱼出血病病毒(GCHV)能够诱导鲤科鱼类培养细胞,如鲫鱼囊胚细胞(CAB)产生类IFN活性物质,并建立宿主细胞的抗病毒状态。为了揭示鱼类培养细胞抗病毒免疫的分子机制,首先建立了一个研究鱼类抗病毒免疫相关基因的细胞模型系统,通过用灭活GCHV诱导CABIFN并进行理化、生物学特性鉴定的基础上,成功建立了一个囊括鱼类细胞抗病毒基因在内的差减cDNA文库。其次,筛选文库揭示了一批与哺乳类IFN系统基因同源以及找不到同源性的EST,表达分析证实它们也是IFN刺激基因。再次,根据哺乳类IFN系统研究的最新进展,从该细胞模型系统中克隆、鉴定了19个IFN系统基因的全长cDNA序列,包括鲫鱼IFN基因,IFN信号传导通路基因STAT1,IFN诱导表达调控基因IRF7,IFN行使抗病毒作用的效应基因Mx1、Mx2、PKR、Viperin、IFI56,以及一些功能未知的IFN刺激基因,如IFI58、ISG1521、ISG1522、Gig1、Gig2等.最后,对部分基因的结构特征、表达特性、诱导机制、分子进化等进行了研究,初步揭示鱼类信号识别、信号传导和抗病毒机制与哺乳类相似。     

论经验在心理免疫能力构建中的作用

人们首次遭遇重大创伤性生活事件时,情绪活动强烈,适应和归于正常的时间较长,而当再次遭遇相似事件时,人们的情绪起伏不大,适应时间相对较短,对事件的敏感性降低,这种差异是由于人们在首次事件后获得了关于创伤事件的经验或认识,当再次面对创伤生活事件时,这些经验和认识能起到一定的指导作用,类似于生物学上的"免疫"能力的产生过程。     

心理免疫系统与心理健康

心理免疫系统是健康的心理保护系统。广义地讲,所有有利于健康维护、保持和提升的策略都是心理免疫系统的结构。心理免疫系统结构包括认知、情绪、人格和行为应对结构。依据压力事件和心理免疫系统交互作用的三种不同结果,心理免疫系统的理论模型包括健康恢复模型、健康维护模型和健康促进模型。目前,心理免疫系统的测量主要采用量表法,间接测量压力恢复的效能因素、适应性因素和压力反应类型。心理免疫系统研究仍需进一步探究其概念、结构层次、功能测定和内部机制,特别是日常烦心事压力水平下心理免疫系统的保护机制。