兔膝半月板滑膜被覆的组织学、组织化学及超微结构的研究

本文通过20支兔膝关节半月板的组织学、组织化学和特染（VG.Mal-lory,Weigert,PMF,PAS,AB,PAS-AB,Feulgen,VonKossaXiGomori等法）以及超微结构（TEM,SEM）,对被覆半月板表面的薄层组织结构性质进行研究,较有说服力地证实为滑膜组织。为长期以来认为半月板有滑膜被覆（但遭到有些学者反对）和运动医学界（含矫形外科）对半月板损伤不需作手术切除,有自行愈合可能等提供形态学理论依据。     

Transportation of AIE-visualized nanoliposomes is dominated by the protein corona

Liposomes, especially cationic liposomes, are the most common and well-investigated nanocarriers for biomedical applications, such as drug and gene delivery. Like other types of nanomaterials, once liposomes are incubated in a biological milieu, their surface can be immediately cloaked by biological components to form a protein corona, which confers a new ‘biological identity’ and modulates downstream interactions with cells. However, it remains unclear how the protein corona affects the transportation mechanism after liposomes interact with cells. Here, we employed home-made aggregation-induced-emission-visualized nanoliposomes TR4@Lipo as a model to investigate transportation with or without the protein corona by optical imaging techniques. The results show that the protein corona can change the cellular transportation mechanism of TR4@Lipo from energy-independent membrane fusion to energy-dependent endocytosis. The protein corona also modulates the intracellular distribution of loaded cargoes. This knowledge furthers our understanding of bio-nano interactions and is important for the efficient use of cationic liposomes.     

用于乙醇-水分离的SA-PVA/PSF中空纤维渗透汽化复合膜

Using polysulfone (PSF) hollow fiber ultrafiltration membranes as the substrate, sodium alginate (SA) and polyvinyl alcohol (PVA) blend solutions as the coating solution, and maleic anhydride (MAC) as the cross-linked agent, SAPVA/PSF hollow fiber composite membranes were prepared for the dehydration of ethanol-water. The effects of different sodium alginate concentration in the coating solutions and different operating temperatures on pervaporation performance were investigated. The experimental results showed that pervaporation performance of the SA-PVA/PSF composite membranes for ethanol-water solution exhibited a high separation factor although they had a relatively low permeation flux. As SA concentration in SA-PVA coating solution was 66.7% and the operating temperature was 40 ℃, SA-PVA/PSF hollow fiber composite membrane (PS4) had a separation factor of 886 and flux of 12.6 g/(m2·h). Besides, SA-PVA/PSF hollow fiber composite membranes (PS3 and PS4) were used for the investigation of the effect of ethanol concentration in the feed solution on pervaporation performance.     

膜分离技术处理新安江水

采用混凝-砂滤-超滤膜的联用工艺对新安江水进行了处理研究,结果表明混凝-砂滤作为预处理能有效地去除大分子的有机物。     

SCI在科学研究中的应用--以膜生物反应器技术为例

长期以来,SCI收录引用被用做评价科研成果的重要指标之一,但其作为权威数据库提供的检索、分析功能却未受到足够的重视。本文介绍了SCI数据库,并且以膜生物反应器技术为例说明SCI对于科研的指导意义。利用SCI提供的Analyze Results对SCI收录的705篇膜生物反应器论文进行了统汁分析,描绘了膜生物反应器的研究概貌。分析内容包括:列出了TOP2O的作者、机构和期刊,并分析了论文的年分布、学科分布、文献类型,重点分析了学科分布分析功能对科研的作用。     

不同负荷训练对大鼠骨骼肌细胞膜自由基代谢、膜流动性及Na~+-K~+-ATP酶活性的影响

探讨不同负荷游泳训练对大鼠骨骼肌细胞膜结构和功能的影响。分别测试不同负荷下膜的抗氧化酶SOD、膜脂质过氧化产物MDA、膜荧光偏振度(P)及膜Na+-K+-ATP酶活性的变化。与对照组相比,小负荷训练组骨骼肌细胞膜P值降低,膜SOD活性、Na+-K+-ATP酶活性提高,膜上MDA含量则降低;大负荷训练组较小负荷组肌膜P值增加,膜SOD活性、Na+-K+-ATP酶活性下降。适宜负荷训练可以提高骨骼肌细胞膜的抗氧化能力,改善膜脂的流动性,使膜Na+-K+-ATP酶活性增强,而过大负荷训练则使骨骼肌细胞膜的抗氧化能力、膜脂的流动性及膜酶活性降低。     

膜法回收丁二烯和氮气混合气相的研究与应用

为了回收丁二烯槽车余气,提高氮气和丁二烯的使用效率,能减少环境污染,笔者在通过现状调研的基础上,对有机蒸汽膜分离的机理进行了研究,并设计膜分离装置的工艺路线,通过技术改造,回收的氮气纯度达到95%,丁二烯的回收率达到90%以上。     

物质跨膜转运机制及最新研究进展

质膜对物质的通透性由膜和物质本身的属性来决定,脂溶性和分子直径不同的物质通过不同方式实现跨膜转运。本文综述了特跨膜转运的几种机制及春最新研究进展情况。     

Changes in erythrocyte membrane glycoproteins during leukaemia

Changes in erythrocyte membrane glycoproteins during, leukaemia were investigated in one hundred patients. Control group contained normal ones. The total protein and protein bound total carbohydrates (neutral sugars) in the glycoproteins extracted from the erythrocyte membrane showed significant reduction in total protein and protein bound total carbohydrates before radiotherapy. However, after the radiotherapy there was further reduction in total protein by 10.41% whereas there was increase in total carbohydrates by 9.98%. Qualitative analysis reveals that with the help of lectins one can pin point the sugars which appear or disappear due to leukaemia. The test could be of a diagnostic value.     

肥胖儿童少年血脂、红细胞膜脂及PS外翻的研究

目的：通过对肥胖儿童少年血脂及红细胞膜脂及磷脂酰丝氨酸（PS）外翻的研究,探讨肥胖对儿童少年脂代谢的影响,为早期监测儿童少年脂代谢紊乱提供理论依据。方法：64名肥胖儿童少年按体脂百分比分为轻度、中度和重度3组,测定其血脂六项、红细胞膜胆固醇、PS外翻量及膜Na＋K＋-ATPase和Ca2＋Mg2＋-ATPase活性。结果：①肥胖儿童少年的TC水平已超过参考标准的理想水平;②肥胖儿童少年血TG与BMI及WC、WHR明显正相关,其中和前两项指标显著性P≤0.01;③轻度肥胖组PS外翻量与其他两组肥胖者之间存在显著性差异（P≤0.05）,HDL仅在轻度肥胖者和重度肥胖者之间存在显著性差异。结论：肥胖儿童少年血脂出现紊乱的潜在可能,PS外翻异常可能比血脂指标更早表现出来,因此对儿童少年肥胖发展的预测和预防可能会有更大的价值。