Application of collagen-chitosan/fibrin glue asymmetric scaffolds in skin tissue engineering

To create a scaffold that is suitable for the construction of tissue-engineered skin, a novel asymmetric porous scaffold with different pore sizes on either side was prepared by combining a collagen-chitosan porous membrane with fibrin glue. Tissue-engineered skin was fabricated using this asymmetric scaffold, fibroblasts, and a human keratinocyte line (HaCaT). Epidermal cells could be seen growing easily and achieved confluence on the fibrin glue on the upper surface of the scaffold. Scanning electron microscopy showed typical shuttle-like fibroblasts adhering to the wall of the scaffold and fluorescence microscopy showed them growing in the dermal layer of the scaffold. The constructed composite skin substitute had a histological structure similar to that of normal skin tissue after three weeks of culture. The results of our study suggest that the asymmetric scaffold is a promising biologically functional material for skin tissue engineering, with prospects for clinical applications.     

The role of callous/unemotional traits in mediating the association between animal abuse exposure and behavior problems among children exposed to intimate partner violence

Children exposed to intimate partner violence are at increased risk for concomitant exposure to maltreatment of companion animals. There is emerging evidence that childhood exposure to maltreatment of companion animals is associated with psychopathology in childhood and adulthood. However, few studies have explored developmental factors that might help to explain pathways from animal maltreatment exposure to children’s maladjustment. The present study addresses this gap in the literature by examining relations between children’s exposure to animal maltreatment, callous/unemotional traits (i.e., callousness, uncaring traits, and unemotional traits), and externalizing and internalizing behavior problems. A sample of 291 ethnically diverse children (55% Latino or Hispanic) between the ages of 7 and 12 was recruited from community-based domestic violence services. A meditational path model indicated that child exposure to animal maltreatment was associated with callousness (β = 0.14), which in turn was associated with greater internalizing (β = 0.32) and externalizing problems (β = 0.47). The effect of animal maltreatment exposure on externalizing problems was mediated through callousness. Results suggest that callous/unemotional traits are a potential mechanism through which childhood exposure to animal maltreatment influences subsequent behavior problems. Future research is needed to evaluate the extent to which exposure to animal maltreatment affects children’s adjustment over time in the context of other co-occurring adverse childhood experiences.     

抑制素免疫对繁殖调控的研究进展

抑制素是一种主要由动物性腺分泌的异二聚体蛋白激素,它通过选择性抑制垂体促性腺激素(主要是FSH)的分泌,进而影响动物的生殖活动。而利用抑制素对动物主动或被动免疫,可增加排卵率,提高繁殖力的独特功能越来越受到人们的重视。本文就近年来有关抑制素免疫对动物生殖功能影响的研究作一综述。     

论我国动物保护立法的基本原则——源于对美国联邦动物福利法的思考

有关我国动物保护法专家建议稿的主要争议在于其是否适应我国国情。美国动物福利法以维护动物福利为目的,以《动物福利法》、《人道屠宰法》和《1877年28小时法》为其主要构成,具体规定了相应的许可、登记、标识、记录、法定标准、执法检查、报告等制度。我国应当予以借鉴,并立足中国国情,在立法设计上坚持有限调整、多层管理、便于操作和责任适当的基本原则。     

动物医学本科专业高素质实践创新人才培养方案研究

实践教学是对学生进行能力培养的重要教学内容。本文就动物医学本科专业高素质实践创新人才的培养方案进行了研究,内容包括构建创新型人才培养的新模式,夯实动物医学本科专业高素质创新人才的培养基础;以现代高新技术强化实践教学内容与环节的改革;建立适合动物医学本科专业实践教学质量保障机制、实践教学管理体系以及实践教学保障条件体系等。     

优秀实验动物站点集锦

介绍了杰克逊实验室等国外实验动物研究机构在因特网 (internet)上建立的站点 ,为加强学术交流 ,发展实验动物科学提供参考。     

影像监控系统在标准化实验动物中的应用

介绍了第四军医大学的综合实验动物大楼内多媒体影像控制系统 ,追踪观察结果表明 :具有可进行实点、滚动监视等 7大技术特点及操作简单 4个功能特点。     

开放系统中层流架饲养清洁级小鼠的微生物控制

在开放或半开放系统中 ,采取对动物引入前驱虫及灭菌、引入后的微生物控制等 5项措施 ,可达到清洁级实验动物的标准。     

西藏农牧业发展的可持续性分析与对策

西藏农牧业可持续发展既有许多有利的因子,如土地、劳动力、生物等资源丰富,环境状况良好,国家优惠政策等;也有其不利的因子,如土地质量差、气候高寒、劳动力素质差、经济基础弱等。西藏农牧业发展,要抓住国家西部大开发和农业结构调整的机遇,对农牧业重新正确定位,加快农牧业制度建设和改革,转变政府农牧业工作思路,在开发资源时注重生态环境保护,发展特色农牧业及相关加工业。     

奥威尔的反极权主义思想——再评被误读的《动物庄园》与《一九八四》

《动物庄园》与《一九八四》是奥威尔的反极权主义小说,一直仅被视作反苏反共反斯大林,这种误读与曲解有其深刻的时代历史原因。《动物庄园》讽喻历史上无数次革命起义所经历的循环模式;《一九八四》既是现代极权社会的真实写照,也是对其未来发展的预言。这两部小说反映出作者对自法国大革命以来整个世界范围各种形态的现代极权社会更宏大深入的思考。