CD19-positive acute myeloblastic leukemia with trisomy 21 as a sole acquired karyotypic abnormality

We report that a 63-year-old Chinese female had acute myeloblastic leukemia (AML) in which trisomy 21 (+21) was found as the sole acquired karyotypic abnormality. The blasts were positive for myeloperoxidase, and the immunophenotype was positive for cluster of differentiation 19 (CD19), CD33, CD34, and human leukocyte antigens (HLA)-DR. The chromosomal analysis of bone marrow showed 47,XX,+21[2]/46,XX[18]. Fluorescent in situ hybridization (FISH) showed that three copies of AML1 were situated in separate chromosomes, and that t(8;21) was negative. The patient did not have any features of Down syndrome. A diagnosis of CD19-positive AML-M5 was established with trisomy 21 as a sole acquired karyotypic abnormality. The patient did not respond well to chemotherapy and died three months after the diagnosis. This is the first reported case of CD19-positive AML with trisomy 21 as the sole cytogenetic abnormality. The possible prognostic significance of the finding in AML with +21 as the sole acquired karyotypic abnormality was discussed.     

新疆各地州市区域经济发展的多元统计分析

本文结合新疆实际,选取了9项适当的主要经济指标对新疆15个地州区域经济发展水平进行了聚类分析和主成份分析。先确立指标体系,用聚类分析法宏观地将新疆15个地州市进行分类,划分的两类具体为：乌鲁木齐、克拉玛依为一类;其余13个地州为一类。接着用主成份分析法微观地对新疆各地州经济发展水平进行排名,最后对结果进行分析。     

知识型人才流动与产业集群发展互动关系研究

知识型人才与产业集群发展密切相关。通过论述知识型人才流动和产业集群发展的现状,分析知识型人才流动对产业集群发展的促进、阻碍影响。运用生命周期理论分析产业集群在发展的不同阶段对知识型人才流动的吸引与排斥影响,发现当前知识型人才流动与产业集群发展互动过程中产生的缺乏合作观念、区域发展不平衡、创新能力不足以及人才市场不完善等问题。提出加大宣传力度、树立合作共赢观念,全面统筹规划、促进区域协调发展,推动机制改革、加强提高自主创新能力,加强引导、完善人才网络等解决措施。     

武汉城市圈网络平台的现状分析及建构设想

受主办单位性质及地域局限性的影响,本应成为武汉城市圈最大信息平台的城市圈综合性网站,在网站设计、信息传播及功能发挥上还存在许多值得改进的地方。文章在分析相关网站的基础上,提出了打造武汉城市圈综合性网络平台的新构想。     

广东省科技期刊集群化发展意愿及构建模式研究

以第一批广东科技类学术期刊(除医学期刊外)为研究对象,调查了期刊编辑对刊群建设的意愿、动机和行为以及在刊群建设中的主要困难及政策需求。结果表明,63%的受访者且大多为非高校学报编辑认为有必要进行集群化建设,他们均认为"编辑出版团队和人才是必须要整合的一项资源";58%的受访者认为集群化建设适合"相同领域且同为核心"的期刊;98%的受访者表示所在期刊未与其他期刊开展合作。提出根据专业领域的不同,以自愿为前提,构设6个系列科技期刊集群。     

Case Report: CD19-positive acute myeloblastic leukemia with trisomy 21 as a sole acquired karyotypic abnormality

We report that a 63-year-old Chinese female had acute myeloblastic leukemia (AML) in which trisomy 21 (+21) was found as the sole acquired karyotypic abnormality. The blasts were positive for myeloperoxidase, and the immunophenotype was positive for cluster of differentiation 19 (CDI9), CD33, CD34, and human leukocyte antigens (HLA)-DR. The chromosomal analysis of bone marrow showed 47,XX,+21 [2]/46,XX[18]. Fluorescent in situ hybridization (FISH) showed that three copies of AML1 were situated in separate chromosomes, and that t(8;21) was negative. The patient did not have any features of Down syndrome. A diagnosis of CD19-positive AML-M5 was established with trisomy 21 as a sole acquired karyotypic abnormality. The patient did not respond well to chemotherapy and died three months after the diagnosis. This is the first reported case of CD19-positive AM L with trisomy 21 as the sole cytogenetic abnormality. The possible prognostic significance of the finding in AML with +21 as the sole acquired karyotypic abnormality was discussed.     

Multivariate statistical analysis for the surface water quality of the Luan River, China

In order to analyze the characteristics of surface water resource quality for the reconstruction of old water treatment plant, multivariate statistical techniques such as cluster analysis and factor analysis were applied to the data of Yuqiao Reservoir-- surface water resource of the Luan River, China. The results of cluster analysis demonstrate that the months of one year were divided into 3 groups and the characteristic of clusters was agreed with the seasonal characteristics in North China. Three factors were derived from the complicated set using factor analysis. Factor 1 included turbidity and chlorophyll, which seemed to be related to the anthropogenic activities; factor 2 included alkaline and hardness, which were related to the natural characteristic of surface water; and factor 3 included Cl and NO2-N affected by mineral and agricultural activities. The sinusoidal shape of the score plots of the three factors shows that the temporal variations caused by natural and human factors are linked to seasonality.     

皖江城市带产业集群发展的“钻石模型”分析

基于皖江城市带产业集群的具体情况,对钻石模型进行修正。随后从资源要素、需求条件、相关与支持性产业、集群的战略结构与竞争、政府作用、机遇、区域文化与外来投资八个方面分析了皖江城市带产业集群的发展,从而提出一些对集群发展有利的对策与建议。     

R&D产业内涵探讨和耦合机制研究

本文通过追溯R&D产业化的演进过程,深入探讨了R&D产业的本质内涵,发现市场导向的R&D产品交易是R&D产业形成的重要标志.R&D产业是以R&D活动为基础,向市场提供具有创意性质的R&D产品作为交易品的经济活动和经济联系.在R&D市场化和产业化过程中,存在两种耦合机制:一是R&D产业价值链中的产品价值创造耦合,另一个是为实现R&D产品创造的产业组织集群创新耦合.我国研发产业发展的战略重点是构建以R&D产业化网络为基础的枢纽-网络结构,区域研发产业发展的政策要点是实施有效的区域知识管理.     

Conceptions of Biology and Approaches to Learning of First Year Biology Students: Introducing a technique for tracking changes in learner profiles over time

We surveyed first year students at the start and at the end of their first semester of university biology (n?=?285) as to their approaches to study (surface, deep) and their conceptions of biology (fragmented, cohesive). Hierarchical cluster analysis was used to group students who responded similarly to the survey; this resolved four Learner Profiles based on specific combinations of approach to study and conception of biology. By comparing cluster membership at the start and end of the semester we could assess whether students (1) maintained their incoming approach to study and conception of the discipline of biology, i.e. their ‘Learner Profile’ and (2) whether certain Learner Profiles were more persistent than others. Approximately half the student cohort did not alter their approach to study or conceptions of biology by semester's end. Students in the disengaged profile, i.e. who returned mostly negative responses to survey items, appeared the most resistant to changing their Learner Profile; while the greatest migration occurred towards less than desirable learning strategies (particularly to the disengaged profile). We were able to confirm the significant migration patterns by assessing the heterogeneity of each cluster at the start of semester clusters with respect to the students' approaches and conceptions at the end of semester. Thus we present a process to accurately track Learner Profile changes that may tell us more about how we can enhance students' learning and provide a means by which to gather the empirical data to support decisions relating to curriculum change.