Evaluation of the clinical chemistry tests analytical performance with Sigma Metric by using different quality specifications - Comparison of analyser actual performance with manufacturer data

IntroductionThe interest in quality management tools/methodologies is gradually increasing to ensure quality and accurate results in line with international standards in clinical laboratories. Six Sigma stands apart from other methodologies with its total quality management system approach. However, the lack of standardization in tolerance limits restricts the advantages for the process. Our study aimed both to evaluate the applicability of analytical quality goals with Roche Cobas c 702 analyser and to determine achievable goals specific to the analyser used.Materials and methodsThe study examined under two main headings as Sigma_laboratory and Sigma_analyser. Sigma_laboratory was calculated using internal and external quality control data by using Roche Cobas c 702 analyser for 21 routine biochemistry parameters and, Sigma_analyser calculation was based on the manufacturer data presented in the package inserts of the reagents used in our laboratory during the study. Sigma values were calculated with the six sigma formula.ResultsConsidering the total number of targets achieved, Sigma_analyser performed best by meeting all CLIA goals, while Sigma_laboratory showed the lowest performance relative to biological variation (BV) desirable goals.ConclusionsThe balance between the applicability and analytical assurance of “goal-setting models” should be well established. Even if the package insert data provided by the manufacturer were used in our study, it was observed that almost a quarter of the evaluated analytes failed to achieve even “acceptable” level performance according to BV-based goals. Therefore, “state-of-the-art” goals for the Six Sigma methodology are considered to be more reasonable, achievable, and compatible with today’s technologies.     

从Σ-协议到公共参考串模型下可否认零知识的高效编译器

给出公共参考串(CRS)模型下可否认零知识的一个正面结果:从Σ-协议到CRS模型下的可否认零知识的高效转化.由Pass在CRYPTO 2003中给出的下界可知,我们的编译器取得了最优的轮效率.此外,转化所增加的通信复杂度较小.     

低相位噪声Σ-Δ小数频率合成器

为使Σ-Δ小数频率合成器获得低带内相位噪声,在设计中调制器采用一种5阶4bit输出的单环Σ-Δ调制器,比3阶MASH(Multi-stAge noise-SHaping)结构有着更低的带内量化噪声.一款具有低带内相位噪声和快速锁定特点的2.6GHz Σ-Δ小数频率合成器在0.25μm CMOS工艺中实现.测试结果显示,该频率合成器在40KHz频率偏移处相噪-86.5dBc/Hz,杂散小于-65dBc.在2.5V的电源供电下,电流为25.5mA,整个芯片面积3.9mm2(核心电路面积0.63mm2).     

6西格玛管理法的特点与运用

6Sigma管理法是一种灵活的综合性系统方法.当今中国企业面对激烈的全球化竞争,要谋求长远的发展,立于不败之地,必须从根本上提高产品或服务的质量,同时又必须保证成本不会因质量的提高而增加,因此有必要引入在国内外成功大企业中颇受青睐的6Sigma管理法.但是在我国企业特殊的情况下,要以一种科学的观点,客观、公正、严慎地实施6西格玛管理,走一条适合中国特色的6西格玛管理之路.     

6 Sigma在改善自复式热敏电阻合格率中的应用

R公司生产线上生产的产品主要是运用在汽车、电子和通讯领域中的标准自复式元件,该元件在电路中平时表现为一个低电阻,一旦电路异常(如高电流,高电压),此产品在搬短的时间内骤然成为一个极高电阻,从而使电路断开,起到一个保险丝的作用,等产品内部的分子链冷却,又重新表现为一个低电阻,可反复起到电路保护的功能.本文主要研究在R生产线的整个流程中生产工艺和各种因素对电阻合格率的影响,运用6Sigma方法找到影响电阻争洛率的关键因素及其最佳的控制水平,使得生产过程受控而且稳定.6Sigma主要过程也称为DMAIC过程(D-定义、M-测量、A-分析、I-改善和C-控制).     

六西格玛理论在图书馆管理中的应用

六西格玛管理理论应用于图书馆管理中,可有效地改善图书馆业务流程、提高图书馆服务质量。介绍六西格玛的含义,阐述图书馆引入六西格玛管理的意义,以图书馆文献传递服务为例,应用六西格玛理论设计出图书馆文献传递服务管理流程,提出图书馆有效实施六西格玛管理的措施。     

基于精益六西格玛的实验教学示范中心服务质量持续改进研究

分析了目前我国普通高校实验教学示范中心服务质量的现状,给出了精益六西格玛高校实验教学示范中心服务质量的应用案例.该精益六西格玛项目通过师生满意度调查收集数据,进行指标的相关性分析,并由重要性系数和满意度指数确定出各个指标在象限图中的位置,据此确定需要改进的指标项目,并追踪改进效果,实现持续精益改进.