Homoharringtonine induces apoptosis of endothelium and down-regulates VEGF expression of K562 cells

Homoharringtonine (HHT) has currently been used successfully in the treatment of acute and chronic myeloid leukemias and has been shown to induce apoptosis of different types of leukemic cells in vitro. Emerging evidence suggests that angiogenesis may play an important role in hematological malignancies, such as leukemia. How ever, whether HHT can relieve leukemia by anti-angiogenesis is still unknown. We investigated the anti-angiogenesis potential of HHT with the human umbilical vein endothelial cell line (ECV304) and leukemic cell line (K562) in vitro. Cellular proliferation was determined by MTT assay and apoptosis was analyzed by flow cytometry. The mRNA expression of vascular endothelial growth factor (VEGF) was assessed by RT-PCR and VEGF protein production was detected by Western blot. Inhibition of cell proliferation and induction of apoptosis by HHT were discovered in ECV304 cells, and appeared in a dose- and time-dependent manner. Also, treatment with HHT caused down-regulation of VEGF mRNA expression in K562 cells in similar dose- and time-dependent manner and inhibition of VEGF protein production in K562 cells in response to the enhancing concentration of HHT. The results demonstrated that HHT could also induce apoptosis in endothelium and down-regulate VEGF expression in K562 cells. In conclusion, we believe HHT has anti-angiogenesis potential and speculate that HHT might exert its anti-leukemia effects via reduction of angiogenesis.     

知识经济时代成人教育发展初探

知识经济时代已经来临,中国的经济体制改革正在向深层次推进,加入WTO后意味着中国将与国际经济接轨,机遇和挑战并存,中国要想在激烈的国际竞争中立于不败之地,必须尽快提高国民素质,大力发展成人教育,探索新型教学方式,培养同知识经济时代相适应的高素质新型人才.     

举办对口招生预科班,提高生源质量

对口招生是职技高师为探索培养有理论,有实践,留得住,用得上的职教师资而进行的一项重要改革。为了提高对口招生生源质量,进一步完善此项改革,今年我院首次举办了对口招生预科班。本文着重从举办预科班的原因、预科班的基本做法、预科班教学计划和培养目标、现状与反映、思考与探索等方面全面介绍预科班的情况。     

Physical design method of MPSoC

Floorplan, clock network and power plan are crucial steps in deep sub-micron system-on-chip design. A novel di- agonal floorplan is integrated to enhance the data sharing between different cores in system-on-chip. Custom clock network con- taining hand-adjusted buffers and variable routing rules is constructed to realize balanced synchronization. Effective power plan considering both IR drop and electromigration achieves high utilization and maintains power integrity in our MediaSoC. Using such methods, deep sub-micron design challenges are managed under a fast prototyping methodology, which greatly shortens the design cycle.     

当代新易家的理论建构——评张其成博士后的易学四书

当代新易家的理论建构为 :中华文化的主干既不是儒家 ,也不是道家 ,而是通贯儒道二家的“易道”。易符、易图、象数是“易道”的载体和表达形式。易学与中国传统生命科学紧密结合在一起。消解科学文化与人文文化的对立 ,消解中国文化与西方文化的冲突 ,促进人与自然的和谐、科学与人文的互补、中西文化的融合是当代新易家的追求目标     

长光程薄层光谱电化学技术及应用

提供电子转移反应实验研究的实验装置及技术，依此可获得电子转移数、式电极电势、式异相电子转移速率常数、电子传递系数及还原态和氧化态的扩散系数等一系列重要的电化学参数。还可依此为基础设计出新颖、实用的教学实验。     

新世纪关于写意花鸟画的思考

当前,写意花鸟画裹足不前,难以发展;写意花鸟画要获得发展,应解决以下问题:向外发展,拓展空间;提高素养,务实创作;精练书法,发挥特长;深入生活,刻苦实践;扩大视野,开拓题材。     

Predicting transition and adjustment to college: biomedical and behavioral science aspirants’ and minority students’ first year of college

The purpose of this study is to explore key factors that impact the college transition of aspiring underrepresented minority students in the biomedical and behavioral sciences, in comparison with White, Asian students and non-science minority students. We examined successful management of the academic environment and sense of belonging during the first college year. Longitudinal data were derived from the Higher Education Research Institute’s (HERI) 2004 Cooperative Institutional Research Program (CIRP) Freshman Survey and the 2005 Your First College Year (YFCY) Survey. Using a reformulation of the integration model (Nora, Barlow, and Crisp, 2005), we find concerns about college financing, negotiating family support and responsibility, and campus racial dynamics (perceived and behavioral) affect student adjustment and sense of integration in the first year. This study was made possible by the support of the National Institute of General Medical Sciences, NIH Grant Number 1 RO1 GMO71968-01. This independent research and the views expressed here do not indicate endorsement by the sponsor.     

课程改革中教师关注阶段理论的研究述评

本文介绍了"关注阶段"的理论架构与评定方法,回顾并分析了它在美国、比利时、荷兰、香港以及澳大利亚等文化情境中的运用与发展.在我国新课程改革背景下进行关注阶段研究不仅有利于我们了解新课程实施情况,而且有助于这一理论自身的发展.     

建设新农村重在培育新农民

建设社会主义新农村需要新型农民。新型农民必须具备较高的思想道德素质，较深的科技文化知识和敏感的市场意识。新型农民的培养一定要强化农村的文化建设、抓好文化知识和职业技术培训以及开展经营素质培训。真正造就有文化、懂技术、会经营的社会主义新型农民。