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5 Benzylidene 2 ,4 thiazolidinedionederivativesarere portedtohavediversebiologicalactivities[1] suchasantidia betic[2 ] ,antibacterial[3] andanticonvulsant[4 ] activities .Forexample,pioglitazoneandrosiglitazonehavebeenlaunchedrecentlyfortypeⅡdiabetesmellitus[2 ] .Theyalsocanbeusedforthetreatmentofpsoriasis[5] andobesity[6 ] . Thegeneralmethodsforthesynthesisof 5 benzylidene 2 ,4 thiazolidinedionewasKnoevenagelcondensationof 2 ,4 thiazolidinedionewitharomaticaldehyde . Inrecentyear… 相似文献
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