基于二模复杂网络的隐性知识发现方法研究——以潜在药物靶点挖掘为例

[目的/意义] 通过构建二模复杂网络模型，揭示隐藏在海量文献中的隐性知识。[方法/过程] 通过NetworkX复杂网络工具包，依据任意两个节点的共现关系构建二模复杂网络模型；对网络模型中节点的共现关系进行加权，计算网络的拓扑信息并进行AP聚类，提取节点间的直接关系；采用AUC方法对AA、JC、加权改进的wAA和wJC等4种链路预测算法进行评价，遴选出最合适的预测算法，并对复杂网络的隐性关系进行预测分析。[结果/结论] 以潜在药物靶点挖掘为例进行的实证研究结果表明，wAA链路预测算法为最优的链路预测算法；二模复杂网络模型、指标和方法体系在美国化学文摘社数据库中的药物靶点挖掘中具有一定的有效性。下一步计划在其他数据库中或其他研究领域中进行尝试，以进一步验证该模型的通用性和有效性。     

Silent Mani Stones

Directors competing for the Best Maiden Director prize of China Golden Roost and Flower Blossom Awards were all big hands but only three were nominated, including prestigious photographer Gu Changwei, new star Liu Hao and nobody Wanma Caidan. When she tore open the envelope, guest announcer Siqin Gaowa said with surprise, ＂The winner is my ethnic minority compatriot.＂ It was Wanma Caidan, a Tibetan black horse who had never been heard in the star-ridden film circle.     

Li Xiaojie：A Popular Flute Performer in the Army

Li Xiaojie is a young Chinese flute performer and now serves as the Chinese flute solo performer in the Song and Dance ! Ensemble of the General Political Department of People＇s Liberation Army. She was born in Inner Mongolia and had followed her father Li Zhen, a famous Chinese flute performer to learn flute performance since her childhood. In 1983, she was admitted to the middle school affiliated to China Conservatory of Music and received an all-round training of sldlls and styles of northern schools of Chinese flute from Prof. Ma Baoshan. In 1986. Li and her schoolmate Zeng Zhaobin performed a flute duet at the Fourth North China Music Festival, which was known as the first ever bamboo flute performance by female performers in China and widely recognized by the professional circle.     

＂Peer Gynt＂ Debuts in the Peking Opera Style

From May 12 through 18, a group of senior students from the opera school of Shanghai Drama Academy, with an average age of 20, staged three opera programs in Beijing, including the Pelting opera programs in Beijing, including the experimental production ＂Peer Gynt＂, the contemporary production ＂On the Top of the Wall, on the Horseback＂ and the adapted classics ＂Qing Feng Ting＂ （Gentle Breeze Pavilion）. The three productions, all of which are original creations by those students, attracted extensive interests and positive comments by the audience, the media and the professional circle. And ＂Peer Gynt＂ captivated most attentions.     

如何从办证窗口做好图书馆的读者服务工作

从更新办证环节为读者服务的工作观念和适应图书馆的发展必须提高自身素质两个方面,阐述作为形象窗口的办证处,如何做好读者服务工作。     

A learning-based method to detect and segment text from scene images

This paper proposes a learning-based method for text detection and text segmentation in natural scene images. First, the input image is decomposed into multiple connected-components (CCs) by Niblack clustering algorithm. Then all the CCs including text CCs and non-text CCs are verified on their text features by a 2-stage classification module, where most non-text CCs are discarded by an attentional cascade classifier and remaining CCs are further verified by an SVM. All the accepted CCs are output to result in text only binary image. Experiments with many images in different scenes showed satisfactory performance of our proposed method.     

Modeling water and carbon fluxes above summer maize field in North China Plain with back-propagation neural networks

INTRODUCTION Dynamics of carbon and water vapor fluxesexchange between the atmosphere and the ecosystembiosphere, depend on complex and non-liner interplayamong physiological, ecological, biochemical andedaphic factors and meteorological conditions (Jarvis,1995; Leuning et al., 1995). There are many studiesquantifying the fluxes across different time and spacescales as well as assessing the environment con-straints on them by some kinds of biophysical orempirical models whose resul…     

ON THE MATHEMAITCAL UNDERSTANDING OF CHAOS

<正> Chaotic motion refers to complicated orbits in dynamical systems.It occurs even in deterministic system governed by simple differential equations and its present has been experimentally verified for many system in several disciplines.In this paper we discuss some of mathematical understanding of chaos.     

Cloning, expression, purification, and characterization of LC-1 ScFv with GFP tag

INTRODUCTION Because of its low molecular weight and ability to fluoresce independently (George, 1997), the new molecular tag, green fluorescent protein (GFP), has become more and more popular after Prasher et al.(1992) cloned its cDNA in 1992. There are many reports describing the co-expression of GFP and a specific antibody or cytokine gene, with the fusion protein expressing the fluorescent activity and bio-logical activity of the complement protein (Haraguchi et al., 1999; Mclean…     

A prototype of workflow management system for construction design projects

1 Introduction 1 In recent years there is a growing understanding of the importance of effective design management to facilitate a coordinated building design within budget, and to ensure the smooth operation of a project [1]. Therefore, it becomes a certain tendency that management of construction design project should combine with information technology (IT) to approach information share and process integration. Since the application of computer-aided design technology (CAD) in China at la…