Treatment and follow-up of children with transient congenital hypothyroidism

Objective: To study the clinical therapy and prognosis in children with transient congenital hypothyroidism (CH).Methods: Fifty-seven children with CH diagnosed after neonatal screening were treated with low-dosage levothyroxine (L-T4).Follow-up evaluation included the determination of TT3, TT4 and TSH serum levels and the assessment of thyroid gland morphology, bone age, growth development and development quotients (DQ). A full check-up was performed at age 2, when the affected children first discontinued the L-T4 treatment for 1 month, and one year later. Development quotients were compared (16.25±3.87) μg/d. Mean duration of therapy was (28.09±9.56) months. No significant difference was found between study group and control group in the DQ test (average score (106.58± 14.40) vs (102.4±8.6), P＞0.05) and 96.49% of the CH children achieved a test score above 85. Bone age, 99mTc scans and ultrasonographic findings were all normal, and evaluation of physical development was normal too, as were the serum levels of TT3, TT4 and TSH after one year of follow-up. Conclusion: A L-T4 dosage of and physical development at age 2. So it is possible for CH children to stop taking medicine if their laboratory findings and physical development are all normal after regular treatment and 2～3 years of follow-up.     

夏季宝宝饮食的医生提要

营养——丰富均衡。以牛奶、豆腐、鱼蛋等高蛋白食物来取代肉类,是保证孩子营养均衡的一大佳法。口感——清凉爽口。建议妈妈们在替孩子准备餐点时,谨记“开胃、好看”的原则,时常准备一些清凉、爽口的食品,如凉拌蔬菜、蔬菜泥、果汁、果泥等。清洁卫生——夏天应保护好小宝贝的肠胃道。购买食物时,应从新鲜度着眼,并避免选购热狗、香肠等具有化学物或添加物的再制品。食用菌类——蘑菇、木耳、金针菇等食用菌类均含有氨基酸和多种维生素,以及铁、镁、钙、磷等多种矿物质元素,是夏季为宝宝补充营养的上佳选择。水分——夏季儿童出汗较多时最…