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Objective: To investigate changes in magnetic resonance spectroscopy (MRS) of lentiform nucleus during the early stage of Parkinson's disease. Methods: Twenty-five patients with idiopathic Parkinson disease with unilateral symptoms (IPDUS) and 25 healthy volunteers were enrolled in this study. MRS of the lentiform nucleus in each patient was taken and then concentrations of N-acetylaspartate (NAA), Creatine (Cr) and Choline (Cho) were calculated. Results: Compared to that in the control, NAA/(Cho Cr) was significantly lower in the lentiform nucleus contralateral to symptoms and even that in the ipsilateral side in IPDUS patients (all P＜0.05); while there was no difference between the two sides in the healthy volunteer (P＞0.05). The ratio of NAA/(Cho Cr) ipsilateral to the sympatomatic side of the patient was also lower than that of the control (P＜0.05). Conclusions: there might be some changes with MRS on the lentiform nucleus during the early stage of idiopathic Parkinson's disease with unilateral symptom. MRS may be one of the reliable methods for early or even sub-clinical diagnosis. 相似文献
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INTRODUCTION Along with the coming of the aged society, the morbidity of Parkinson抯 disease is also raised. But there is lack of objective experimental diagnostic indexes for it during the early stage. Magnetic resonance spectroscopy (MRS) is a noninvasive technique for measuring the chemical compounds in the human body. 1H MRS can be used to analyze many metabolites, such as N-acetyaspartate (NAA), Creatine (Cr), Choline (Cho) and so on. In Parkin-son抯 disease, the concentratio… 相似文献
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