Science Letters:Brain metastases of melanoma-mechanisms of attack on their defence system by engineered stem cells in the microenvironment

This report gives a better emphasis on the role of targeted effectors (e.g. a combination of 5-FC with CD-NSPCs as compared to the application of NSPCs alone) and how such delivery of pro-drug activating enzymes and other tumor-killing substances may overcome melanocytic defence system, interact with and promote the host defence and immune response modulations not only in melanoma but, potentially, in other highly-metastatic cancers.     

A CAD Software Package for Education in the Discipline of Machine Element Design

This paper outlines the experience in developing and teaching with a CAD software package for education in the discipline of machine element design. The package was designed in the Machine Element Department at the Technical University Sofia, Bulgaria, and has been used by students in developing their projects on the subject for 3 years. The advanced scientific and industrial methods of machine elements design are used in the package. The purpose of creating the package is to stimulate creativity and flexibility in the students’ imagination. It gives new opportunities for teaching machine elements design in higher education.     

Processing Times Modeled by Reliability Systems with a Random Number of Spare Units

A processing job with high reliability of final results is requested. It is performed as a multi-stage process. The facility at each stage may work correctly or malfunction. To enter any subsequent stage a secure result from the previous stage is required. This leads to the necessity of duplication of jobs at each stage many (random number of) times to provide two coinciding results, and a successful and reliable end. Then the total processing time, the quality of total processing of the job and related characteristics are modeled like those in a reliability system with random redundancy. Some analogies with the conventional results in reliability theory apply. Optimization problems are formulated and examples from information traffic are shown.