The celestial mechanics of Newton

Newton’s law of universal gravitation laid the physical foundation of celestial mechanics. This article reviews the steps towards the law of gravitation, and highlights some applications to celestial mechanics found in Newton’sPrincipia. His research interests cover all types of cosmic explosions and their remnants.     

解决分布式需求的内在冲突

2006年8月,GEN(I网络创新的全球化环境)项目组公布其项目的设计原则。来自普林斯顿大学、麻省理工大学、华盛顿大学等学校的十二位专家编写了这份报告。该报告阐述了GENI的研究范围、用户的需求、需求的内在压力,以及工程设计的原则。报告指出了GENI的价值主张,广泛的部署、多样化可扩展的网络技术集合、对真实用户流量的支持仍是GENI关注的原则和方向。上期已经介绍第一部分——“分布式需求定义GENI的重心”,本期刊出第二部分——“解决分布式需求的内在冲突”。     

The major players in adaptive immunity

How do we remain healthy, for the most parts, in the midst of an environment teeming with opportunistic and infectious microbes, potential carcinogens and allergens? The fact is that our immune system, by and large, does a fine job in protecting us. It is therefore important to understand the organization of the immune network, which is broadly categorized into two groups: innate and adaptive. Cells involved in innate immunity are the first to come into contact with invading microbes, similar to the border security force, and respond rapidly but in a non-specific manner. On the other hand, the cells involved in adaptive immunity are slower to respond but act in a very specific manner. Though the primary response is slow, the secondary response is much faster and demonstrates memory. This article will focus on some important features and key players involved in the adaptive immune response. The first part deals with the humoral immune response mediated mainly by immunoglobulins produced by the B cells. The second part deals with T cells, the Major Histocompatibility Complex (MHC)-encoded molecules, and Recombination Activating Genes (RAG) responsible for generating diverse B-cell receptors (BCR) and T-cell receptors (TCR). With the advent of newer and smarter infectious agents, it is important to understand the working of the immune network as more research in this area may facilitate the development of better protective strategies.     

Innate immunity and the 2011 Nobel Prize

The 2011 Nobel Prize inMedicine or Physiology was awarded to Jules Hoffmann, Bruce Beutler and Ralph Steinman for their contributions in the area of Innate Immunity. This review introduces the readers to innate immunity and links the studies of the awardees to this area of research. The cells and mechanisms involved in the innate immune response are reviewed with a special emphasis on the discovery of the Toll receptors in Drosophila and the Toll-like receptors in mammals. The importance of the innate response during inflammatory conditions is discussed and examples of genes related to innate immunity that cause disease are also highlighted. Finally, the roles of innate immunity in modulating adaptive immune response, especially with respect to dendritic cells, are discussed. Further studies in this area are likely to enhance our understanding of the immune response and may lead to drugs to ameliorate excessive inflammatory responses.     

Capacity building of a district education system: insights from Kenya

Both (a) in-school factors such as over-focus on academic performance, absence of uniform, and corporal punishment, and (b) out-of school factors such as caring for ailing parents, child labour, etc., hinder participation of orphan and vulnerable children (OVC) in Free Primary Education (FPE) system in Nyanza Province, Kenya. In this context Concern Worldwide Kenya undertook an appreciative capacity building approach and appropriately positioned District Education Office (DEO) of the Ministry of Education and local civil society organisations (CSOs) to address in-school and out-of-school factors, respectively, to ensure quality education for OVC. The outcome of the programme is promising and has demonstrated the need for greater cooperation between CSOs and the government to develop creative strategies in overcoming the causes of marginalisation within the contexts of the growing AIDS pandemic and poverty in Kenya.     

Sapria Himalayana

Sighting Sapria in the wild is a lifetime experience for a botanist. Because this rare, parasitic flowering plant is one of the lesser known and poorly understood taxa, which is on the brink of extinction. In India, Sapria is only found in the forests of Namdapha National Park in Arunachal Pradesh. In this article, an attempt has been made to document the diversity, distribution, ecology, and conservation need of this valuable plant.     

‘If the child cannot come to the school,then the school must go to the child’: The railway station platform schools in Odisha,India

Despite its constitutional obligation of ensuring universal primary education, the Indian Government has not been able to find a way to educate its 18 million street children. It is widely accepted that the government lacks the capacity – financial, managerial and human resource – to provide meaningful education to those who are left out of the formal education system. Many civil society organisations across India are trying to bridge the gap by educating children living in high-risk settings. One such initiative, the Railway Platform School started by Ruchika, proves that quality bridge or condensed courses are an effective way of encouraging children to access the formal education system. This article argues that the government needs to appreciate and support this kind of innovative initiatives, and also government and other civil society actors needs to operate under a collaborative framework to ensure reach out to children, who have been left out of the Government schooling system.     

The major players in adaptive immunity

Our immune system, by and large, does a fine job in protecting us from opportunistic and infectious microbes, potential carcinogens and allergens. It is therefore crucial to understand the organization of the immune network. This article focuses on some important features and key players involved in adaptive immune response. The first part of the article dealt with the humoral immune response mediated mainly by immunoglobulins produced by the B cells. The second part deals with T cells, the Major Histocompatibility Complex (MHC)-encoded molecules, and Recombination Activating Genes (RAG) responsible for generating diverse B-cell receptors (BCR) and T-cell receptors (TCR). With the advent of newer and smarter infectious agents, it is important to understand the working of the immune network as more research in this area may facilitate the development of better protective strategies.     

GENI的设计原则(一)分布式需求定义GENI的重心

2006年8月,GEN(I网络创新的全球化环境)公布其项目的设计原则。来自普林斯顿大学、麻省理工大学、华盛顿大学等学校的十二位专家编写了这份报告。该报告阐述了GENI的研究范围、用户的需求、需求的内在压力以及工程设计的原则。报告指出了GENI的价值主张,广泛的部署、多样化可扩展的网络技术集合、对真实用户流量的支持仍是GENI关注的原则和方向。本刊将分两期连载这一报告,从“分布式需求定义GENI的重心”、“解决分布式需求的内在冲突”等两部分,将这一报告与大家共享。     

Thymus

The immune system protects our bodies against infections and cancers. This review introduce readers to the thymus – a primary lymphoid organ – which is the site of development and maturation of functional T lymphocytes. Progenitor stem cells arise from the bone marrow and undergo sequential development in the thymus where non-self-reactive T cells are selected. Subsequently, post selection and maturation, the mature T cells exit the thymus as naïve T cells into the peripheral lymph nodes. Studies on the thymus are likely to enhance our understanding of T cell development and reduce disease burdens by improving the cellular immune response.