从馆藏图书借阅状况分析我校读者借阅需求

通过对我馆馆藏图书借阅状况统计的分析,了解、掌握我校读者的借阅需求,从而为图书的采访、藏书整合、读者导读提供依据。     

Herceptin functionalized microfluidic polydimethylsiloxane devices for the capture of human epidermal growth factor receptor 2 positive circulating breast cancer cells

Building on recent breakthroughs in the field of microfluidic-based capture of rare cancer cells circulating in the blood, the present article reports on the use of Herceptin functionalized PDMS devices designed to efficiently capture from blood cancer cells, overexpressing the tyrosine kinase human epidermal growth factor receptor (HER2). The identification of patients overexpressing HER2 is critical as it typically associates with an aggressive disease course in breast cancer and poor prognosis. Importantly, HER2 positive patients have been found to significantly benefit from Herceptin (Trastuzumab), a humanized monoclonal antibody (MAb) against HER2. Disposable PDMS devices prepared using standard soft lithography were functionalized by the plasma polymerization of an epoxy-containing monomer. The epoxy-rich thin film (AGEpp) thus created could be conjugated with Herceptin either directly or through a polyethylene glycol interlayer. The properties and reactivity toward the monoclonal antibody conjugation of these coatings were determined using x-ray photoelectron spectroscopy; direct conjugation provided a good compromise in reactivity and resistance to biologically nonspecific fouling and was selected. Using the breast cancer cell line SK-BR-3 as a model for cells overexpressing HER2, the immunocapture efficacy of the Herceptin functionalized PDMS was demonstrated in model studies. Validation studies confirmed the ability of the device to efficiently capture (～80% capture yield) HER2 positive cells from full blood.     

Small and Medium-Sized Enterprises in Rural Business Clusters: The Relation Between ICT Adoption and Benefits Derived From Cluster Membership

This study examines the relationships between information and communication technologies (ICT) usage, the benefits a company derives from membership in a rural business cluster, and the success of rural companies. Analysis of 333 rural businesses located in northern lower Michigan showed a strong relationship between (a) ICT adoption and benefits derived from the membership in business clusters, (b) ICT adoption and self-reported business success, and (c) benefits derived from business clusters and business success. Although analysis indicates that these relationships may be industry specific, results suggest that ICT adoption by rural enterprises may have advantages for the region's social capital and business success and may help reduce the digital divide experienced in rural communities.     

The use of public computing facilities by library patrons: demography,motivations, and barriers

Public libraries play an important part in the development of a community. Today, they are seen as more than store houses of books; they are also responsible for the dissemination of online, and offline information. Public access computers are becoming increasingly popular as more and more people understand the need for internet access. Using a series of surveys conducted in 12 libraries across the state of Michigan, the current study is a step towards understanding why the computing facilities are widely used, and what are the motivations behind their use. In addition, barriers and other factors that hinder usage are also discussed. The findings from this study will help policy makers and library administrators evaluate the current allocation of scarce resources, help them promote greater use of the library's resources, and guide their future course of action. The study is conducted as part of a federally funded public computing center grant.     

Public broadband investment priorities in the United States: an analysis of the broadband technology opportunities program

In 2009, U.S. Congress approved $7.2 billion to accelerate the deployment of advanced broadband networks and services to unserved and underserved regions of the country. Although primarily a short-term response to the economic crisis, the appropriation also indicates a willingness to seek a new balance between private sector and public sector initiatives in the development of the nation's broadband infrastructure. This paper is a first step in assessing the potential impact of the new government initiatives. It discusses in detail one component of the overall program, the Broadband Technology Opportunities Program (BTOP). The rationales and objectives of BTOP and its initial implementation are explored. Based on information in the BTOP database, 265 awards were examined to document award types, target communities, applications, technology, and access speeds. Whereas it is too early to assess the initiatives' effects on employment and other important social and economic objectives, it is appropriate to consider whether the awards made under the BTOP program advance a national broadband development agenda. Overall, they appear to. However, the present analysis found that projects focusing on minority populations may have received less emphasis in the BTOP awards than that announced in the stated goals of the program.