Carnosine in health and disease

Abstract

Carnosine was originally discovered in skeletal muscle, where it exists in larger amounts than in other tissues. The majority of research into the physiological roles of carnosine have been conducted on skeletal muscle. Given this and the potential for muscle carnosine content to be increased with supplementation, there is now a large body of research examining the ergogenic effects (or otherwise) of carnosine. More recent research, however, points towards a potential for carnosine to exert a wider range of physiological effects in other tissues, including the brain, heart, pancreas, kidney and cancer cells. Taken together, this is suggestive of a potential for carnosine to have therapeutic benefits in health and disease, although this is by no means without complication. Herein, we will provide a review of the current literature relating to the potential therapeutic effects of carnosine in health and disease.     

Book reviews

Association of Research Libraries     

The inadvertent creation of a neocolonial culture: A study of western sojourners in India

Field work and structured interviews with 139 foreign sojourners in India were analyzed to describe the socialization of aliens into their role. Attitude scales measuring favorability toward the host country and people were also examined in relation to the respondent's occupational status and elapsed time in India. The results from the field work and interviews suggest that the privileges and high status accorded many Western visitors may contribute to the visitors' derogation of their hosts, a process which is often subtle but unmistakable. The visitors appear to become socialized into the world of aliens rather than the world of their hosts. The higher the visitor's status and the longer the elapsed time in India, the more pronounced these patterns appear. While the correlational nature of the study makes it impossible to determine whether persons with initially unfavorable attitudes are selected into the high status positions or whether the positions themselves create such attitudes, it appears reasonable to conclude that there would be less derogation and alienation if the lures of status and money were removed; persons would be neither selected nor influenced by such factors.     

Mapping the educational experiences of children with pathological demand avoidance

‘Pathological demand avoidance’ (PDA) describes a pattern of difficulties increasingly recognised as forming part of the autistic spectrum. Although clinical reports suggest that children with PDA are likely to experience considerable difficulties in education, their educational experiences have not yet been explored in any systematic way. In the current study, 42 parents of children with PDA completed a questionnaire about their child's educational experiences. Parents' responses indicated that this group of children displays high levels of problem behaviours in school, and receives corresponding high levels of special educational need support and professional involvement. Despite this support, the group had experienced high rates of exclusion and placement breakdown, with only 48% now in mainstream education. Parents reported relatively high satisfaction in their children's educational placements, with success defined by parents in terms of child outcomes, school characteristics and PDA‐specific factors. Findings are discussed with reference to what is known about the educational experiences of children with more typical autism spectrum conditions and in terms of the implications for the inclusion of this group of children with complex needs.     

Gender positioning in teacher education in England: New rhetoric,old realities

This article presents data from a series of life-history interviews with female student teachers of physical education. The intention is to forge links between the experiences of female student teachers, and their 'gender positioning' within the micro-politics of teacher education and the wider discourse that informs these interactions. On first entering teaching these women tended to adopt or enter 'survival mode', which endorsed particular professional identities that were consolidated by a form of instrumental rationality. These professional identities were closely tied to conventional conceptions of masculinity, and legitimated and contributed to, the reinforcement of particular gender inequalities in teacher education. The analysis suggests that a liberal discourse of equal opportunities masks the institutionalisation of social 'otherness' and inequality and supports the 'essentialisation' of male and female identities.     

Assessment in special schools: national early assessment procedures and pupils attending special schools in England

An implicit assumption that fostering inclusion means having shared systems encompassing the needs of all children is evident in many aspects of policy development over the past decade. Reflecting this, the implementation of ‘baseline assessment’ schemes (i.e. testing at around age 5 years) is a statutory requirement on all state-maintained special and mainstream schools in England since 1998. Our argument is that the enthusiasm for commonality has obscured the need to question the value and validity of baseline assessment schemes for children with special educational needs (and possibly some others such as children having English as an additional language). We illustrate this position with reference to data from our recent study on baseline assessment in England. The study encompassed survey data from a national sample of 982 schools, of which 107 were special schools. Between them, these special schools used 42 different baseline assessment schemes. Comparisons between our mainstream and special school respondents indicated that there were similarities in the nature and perceived value of the schemes used. However, special schools were less satisfied with their schemes. We suggest that a reappraisal of the nature and purpose of baseline assessment for pupils with special educational needs warrants greater critical debate. Without this, there is a danger that a stress on commonality, veiling an inclusion orthodoxy, will ultimately be counterproductive.