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One of the most salient arguments in favor of a semiotic approach, put forward on various occasions among others by Luis Radford, claims that semiotics is most appropriate to treat the interaction between socio-cultural and objective aspects of knowledge problems. But if we want to take such claims seriously, we have to undertake revisions of our basic conceptions about reality, existence, cognition, and cultural development. The semiotic evolutionary realism of Charles S. Peirce provides, or so it appears, an appropriate basis to such intentions. Man is a sign, Peirce had famously said, and ??thought is more without us than within. It is we that are in it, rather than it in any of us?? (Peirce CP 8.256). And as there is no thought without a sign, we have to accept thoughts, concepts, theories, or works of art as realities sui generis. Concepts or theories have to be recognized as real before we can ask for their meaning or relevance. This was the problem that concerned critics and protagonists of the New Math Reform of the 1960s and 1970s of the twentieth century, like Thom or Bruner.  相似文献   
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This conceptual article discusses strategies of corporations in the information and communication technologies (ICT) sector and their role in the conflict over access to knowledge in the digital environment. Its main hypothesis is that ICT corporations are very capable actors when it comes to bridging digital divides in both developed and developing countries??maybe even the most capable actors. Therefore, it is argued that ICT corporations could use their capabilities to help citizens gain sustainable access to knowledge in order to enable them to lead self-sufficient lives. In a nutshell, capabilities are presented as both the input (capabilities of ICT corporations) as well as the output (capability building for empowering citizens) of corporate strategy-making focusing on fair ICT. Corporate citizenship is put forth as the theoretical concept bridging corporate strategies and access to knowledge: If ICT corporations act in accordance with their self-understanding of being ??good corporate citizens??, they could be crucial partners in lessening digital divides and helping citizens gain access to knowledge. From the perspective of ??integrative economic ethics?? (Ulrich 2008), it is argued that ICT corporations have good reason to actively empower citizens in both developed and developing countries by pursuing ??inclusive?? strategies in many fields, such as open-source software development. That way, ICT corporations could enable, support and provide citizens with capabilities enabling them to help themselves. In order to make inclusive business models work, the rules and regulations companies find themselves in today must enable them to act responsibly without getting penalized by more ruthless competitors. This article explores several cases from the ICT field to illustrate the interplay between a responsible business model and the rules and regulations of the industry. From a capabilities perspective, the most desirable mix of corporate strategies and industry regulation is one that results in the highest level of generativity (Zittrain 2008). Thus, ICT should not be closed systems only driven by the company behind them. Instead, they need to be open for the highest possible level of third-party innovation.  相似文献   
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Separation and sorting of biological entities (viruses, bacteria, and cells) is a critical step in any microfluidic lab-on-a-chip device. Acoustofluidics platforms have demonstrated their ability to use physical characteristics of cells to perform label-free separation. Bandpass-type sorting methods of medium-sized entities from a mixture have been presented using acoustic techniques; however, they require multiple transducers, lack support for various target populations, can be sensitive to flow variations, or have not been verified for continuous flow sorting of biological cells. To our knowledge, this paper presents the first acoustic bandpass method that overcomes all these limitations and presents an inherently reconfigurable technique with a single transducer pair for stable continuous flow sorting of blood cells. The sorting method is first demonstrated for polystyrene particles of sizes 6, 10, and 14.5 μm in diameter with measured purity and efficiency coefficients above 75 ± 6% and 85 ± 9%, respectively. The sorting strategy was further validated in the separation of red blood cells from white blood cells and 1 μm polystyrene particles with 78 ± 8% efficiency and 74 ± 6% purity, respectively, at a flow rate of at least 1 μl/min, enabling to process finger prick blood samples within minutes.  相似文献   
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The unification of the two German states in October 1990 had a significant impact on educational politics. The combination of two educational and university systems that were based on clearly divergent political and social foundations lay ahead. The thesis is discussed here that the unification of FRG and GDR could not lead to the renewal of universities in Germany but only to an adaptation of eastern society to western society. But with the foundation of a Faculty of Educational Sciences at the Technical University of Dresden (Land Saxony) successful attempts to renewals at an intermediate level are also presented. The author describes the production and realization of a project he helped to develop and at the same time addresses the emerging problems the new faculty triggered.  相似文献   
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