Regularities in the E. coli promoters composition in connection with the DNA strands interaction and promoter activity

INTRODUCTION It is well known that the physical properties, namely DNA strands interaction in promoter are connected with their activity. As it was established the two promoter regions ?35 and ?10 are the most important for the promoter functioning, all bases in the ?35 (TTGACA) and ?10 (TATAAT) hexamers were highly conserved (Harley and Reynolds, 1987; Hawley and McClure, 1983). The functional impor- tance of these sequences was proved in many inves- tigations (Record et al., 199…