The effects of order of shock durations on helplessness in rats

Whereas rats exposed to a series of progressively decreasing shock durations show deficits in shuttle-escape performance 24 h later, the same number and intensity of shocks in the reverse (increasing) order of durations does not produce the “learned helplessness” effect (Balleine & Job, 1991). We conducted two experiments to establish the generality of this shock-duration order effect on other measures of distress and helplessness in rats. In Experiment 1, rats exposed to decreasing durations of inescapable shock showed reduced consumption of quinine-adulterated water (finickiness), whereas increasing durations produced no finickiness. By contrast, increasing shock durations produced greater conditioned fear to the shock context than did decreasing shock durations in Experiment 2. The differential effects of shock-duration order on finickiness and fear are explicated in terms of the specificity of fear conditioning during exposure to increasing versus decreasing series of shock duration orders.     

Connecting the Dots Between Past and Future: Constraints in Episodic Future Thinking in Early Childhood

Preschoolers have limited capacity to use past experiences to prepare for the future. Two experiments sought to further understand these limitations. Experiment 1 (N = 42) showed that 3- to 4-year olds’ difficulty performing anticipated future actions was constrained by their memory for relevant past actions, especially those including temporal information. Experiment 2 (N = 94) sought to determine whether preschoolers fail to see that past experiences can inform future-oriented actions. When the connection between the past and future was experimentally heightened, future thinking accuracy improved, but only if preschoolers remembered past experiences. The results indicate that past recall is a prerequisite for future thinking but failure to bridge past and future further accounts for observed limitations in future thinking in early childhood.     

A low-cost 3D printed microfluidic bioreactor and imaging chamber for live-organoid imaging

Organoids are biological systems grown in vitro and are observed to self-organize into 3D cellular tissues of specific organs. Brain organoids have emerged as valuable models for the study of human brain development in health and disease. Researchers are now in need of improved culturing and imaging tools to capture the in vitro dynamics of development processes in the brain. Here, we describe the design of a microfluidic chip and bioreactor, to enable in situ tracking and imaging of brain organoids on-chip. The low-cost 3D printed microfluidic bioreactor supports organoid growth and provides an optimal imaging chamber for live-organoid imaging, with drug delivery support. This fully isolated design of a live-cell imaging and culturing platform enables long-term live-imaging of the intact live brain organoids as it grows. We can thus analyze their self-organization in a controlled environment with high temporal and spatial resolution.     

Loneliness,fear of falling,and quality of life in community-dwelling older women who live alone and live with others

Background: One of the health indexes is living arrangement and nowadays has tended toward living alone which has terrible negative impacts on the elderly’s social health in Asia. About 62.2% of lonely older adults are afraid of falling. In addition, the activity level of them is much more limited.

Aim: The aim of this article is to compare loneliness, fear of falling, and quality of life in older women who live alone and live with others.

Methods: This cross-sectional study was done on 218 accessible elderly women (116 live alone, 102 live with others) to compare loneliness, fear of falling, and quality of life by using the Farsi versions of UCLA-LS, falls efficacy scale-international (FES-I), and SF12 questionnaires, respectively.

Results: Linear regression was used to compare the means of continuous outcomes between the two groups by adjustment on probable confounder’s age and falling history.

Conclusion: Fears of falling and physical aspect of life quality in the lonely older adults were considerably higher than other group.     

A teaching skills workshop on video feedback in Western India

For the past five years he has specialized in the sociology of water resources usage in the Indian subcontinent.