The neural correlates of working memory training in typically developing children

Working memory training improves children's cognitive performance on untrained tasks; however, little is known about the underlying neural mechanisms. This was investigated in 32 typically developing children aged 10–14 years (19 girls and 13 boys) using a randomized controlled design and multi-modal magnetic resonance imaging (Devon, UK; 2015–2016). Training improved working memory performance and increased intrinsic functional connectivity between the bilateral intraparietal sulci. Furthermore, improvements in working memory were associated with greater recruitment of the left middle frontal gyrus on a complex span task. Repeated engagement of fronto-parietal regions during training may increase their activity and functional connectivity over time, affording greater working memory performance. The plausibility of generalizable cognitive benefits from a neurobiological perspective and implications for neurodevelopmental theory are discussed.     

Carnosine in health and disease

Abstract

Carnosine was originally discovered in skeletal muscle, where it exists in larger amounts than in other tissues. The majority of research into the physiological roles of carnosine have been conducted on skeletal muscle. Given this and the potential for muscle carnosine content to be increased with supplementation, there is now a large body of research examining the ergogenic effects (or otherwise) of carnosine. More recent research, however, points towards a potential for carnosine to exert a wider range of physiological effects in other tissues, including the brain, heart, pancreas, kidney and cancer cells. Taken together, this is suggestive of a potential for carnosine to have therapeutic benefits in health and disease, although this is by no means without complication. Herein, we will provide a review of the current literature relating to the potential therapeutic effects of carnosine in health and disease.     

A Corpus-Based Learning Method of Compound Noun Indexing Rules for Korean

In Korean information retrieval, compound nouns play an important role in improving precision in search experiments. There are two major approaches to compound noun indexing in Korean: statistical and linguistic. Each method, however, has its own shortcomings, such as limitations when indexing diverse types of compound nouns, over-generation of compound nouns, and data sparseness in training. In this paper, we propose a corpus-based learning method, which can index diverse types of compound nouns using rules automatically extracted from a large corpus. The automatic learning method is more portable and requires less human effort, although it exhibits a performance level similar to the manual-linguistic approach. We also present a new filtering method to solve the problems of compound noun over-generation and data sparseness.     

A focus on quality--the library's role in occurrence screening

One of the highest priorities in today's hospitals is the provision of quality care to patients. The medical librarian has an increased responsibility to furnish quality information to the medical staff. Traditional methods of reference service continue to work well, but it is increasingly important for librarians to become more directly involved in hospital quality assurance (QA) activities. Occurrence screening is one system of QA where the librarian can make a difference.