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Danny Bavli Elishai Ezra Daniel Kitsberg Margarita Vosk-Artzi Shashi K. Murthy Yaakov Nahmias 《Biomicrofluidics》2016,10(2)
Cell-cell interactions play a key role in regeneration, differentiation, and basic tissue function taking place under physiological shear forces. However, current solutions to mimic such interactions by micro-patterning cells within microfluidic devices have low resolution, high fabrication complexity, and are limited to one or two cell types. Here, we present a microfluidic platform capable of laminar patterning of any biotin-labeled peptide using streptavidin-based surface chemistry. The design permits the generation of arbitrary cell patterns from heterogeneous mixtures in microfluidic devices. We demonstrate the robust co-patterning of α-CD24, α-ASGPR-1, and α-Tie2 antibodies for rapid isolation and co-patterning of mixtures of hepatocytes and endothelial cells. In addition to one-step isolation and patterning, our design permits step-wise patterning of multiple cell types and empty spaces to create complex cellular geometries in vitro. In conclusion, we developed a microfluidic device that permits the generation of perfusable tissue-like patterns in microfluidic devices by directly injecting complex cell mixtures such as differentiated stem cells or tissue digests with minimal sample preparation. 相似文献
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In this critical review of literature, we summarize the major theoretical frameworks that have been used to study teacher mobility. In total we identified 40 teacher mobility studies that met our inclusion criteria. We conclude that relatively few theoretical frameworks have been used to study teacher mobility and those that have been used are lacking in several key areas. Specifically, none of the current teacher mobility theories are able to adequately account for the many teacher- and school-level factors that likely influence teachers’ professional decisions. Finally, we suggest a theoretical framework from the organizational psychology literature that can address the shortcomings of theories identified in this review. 相似文献
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The identification of children who are twice‐exceptional—those who are gifted and have concomitant learning disabilities (LDs)—has historically posed a number of challenges for school psychologists and other school personnel. With the reauthorization of the Individuals With Disabilities Education Act and the shift to the use of a Response‐to‐Intervention (RtI) model to identify students with LDs, the task of identifying those who are twice exceptional is even more daunting. This article proposes an integrated model for the identification of gifted children with LDs that blends standardized assessment methods with practices consistent with RtI. This balanced approach brings together the best of both worlds to more accurately identify twice‐exceptional students and better meet their educational needs. © 2010 Wiley Periodicals, Inc. 相似文献
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Julio Guerra Margarita Ortiz-Rojas Miguel Angel Zúñiga-Prieto Eliana Scheihing Alberto Jiménez Tom Broos Tinne De Laet Katrien Verbert 《British journal of educational technology : journal of the Council for Educational Technology》2020,51(4):973-1001
Despite the success of academic advising dashboards in several higher educational institutions (HEI), these dashboards are still under-explored in Latin American HEI's. To close this gap, three different Latin American universities adapted an existing advising dashboard, originally deployed at the KU Leuven to their own context. In all three cases, the context was the main ruling factor to these adaptations. In this paper, we describe these adaptions using a framework that focuses on four different elements of the context: Objectives, Stakeholders, Key moment and Interactions. Evaluation of the adapted dashboards in the three different Latin American universities is conducted through pilots. This evaluation shows the value of the dashboard approach in different contexts in terms of satisfaction, usefulness and impact in academic decision-making and advising tasks. The main contribution of this paper is the systematic reporting of the adaptations to an academic advising dashboard and showing the value of an academic advising dashboard on academic decision-making and advising tasks. 相似文献
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Julia Crespo Comesa?a Margarita Pino Juste 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》2007,24(1):205-218
The objective of this study is to offer a view on the different environmental factors that affect health (sound, light, colour,
temperature) in the design, planning and organization of school premises. To achieve this, the authors first outline the problems
leading to unhealthy situations. They subsequently analyse all the building and planning factors behind those problems based
on a study carried out in the Autonomous Community of Galicia, in the north west of Spain. The study took as its subject all
secondary-level education centres built in Galicia since the Spanish Basic Act on the Educational System (LOGSE) was passed
by the Spanish Parliament in 1990. To conclude, the article offers a number of guidelines to be taken into account when designing
a school environment. 相似文献
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Tiberio Garza Margarita Huerta Tracy G. Spies Rafael Lara-Alecio Beverly J. Irby Fuhui Tong 《International Journal of Science and Mathematics Education》2018,16(8):1499-1519
Academic language is critical for English learners (ELs) to succeed in the science classroom. This study analyzed the instructional practices centered around academic language taking place in eight, fifth-grade classrooms during a grant-funded project. Observational data collected through a classroom observation instrument were analyzed to describe and compare the instructional practices occurring in treatment and control classrooms when teachers and students used academic language. Our findings show both treatment and control classrooms using academic language during the course of the intervention study, but the instruction looked markedly different in each setting. These differences provide valuable insight for practitioners and researchers concerned with the academic language development of ELs in science classrooms. 相似文献
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Malva Villalón Bravo Corresponding author Margarita Silva Tonia Razmilic Stanley L. Swartz 《Early Years: An International Journal of Research and Development》2005,25(2):97-111
After one year of implementation, this paper describes a programme designed to support literacy learning in low performing schools from poor sectors in Santiago, Chile. School‐based intensive training on theory and practice of a literacy learning framework for classroom instruction and long‐term support were used to impact the achievement of students from disadvantaged families in 16 kindergarten classrooms and 16 1st‐grade classrooms in nine primary schools. Preliminary results showed an improvement in learning achievement positively related to level of implementation of the literacy instruction framework in the classrooms and teachers' perception of an improvement in their knowledge and classroom practices. Although findings from this study cannot support definite conclusions, because of the lack of experimental conditions, they provide relevant information for future experimental studies on how to meet the literacy learning needs of children from disadvantaged backgrounds. 相似文献
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Three‐Year‐Olds’ Reactions to a Partner's Failure to Perform Her Role in a Joint Commitment 下载免费PDF全文
When children make a joint commitment to collaborate, obligations are created. Pairs of 3‐year‐old children (N = 144) made a joint commitment to play a game. In three different conditions the game was interrupted in the middle either because: (a) the partner child intentionally defected, (b) the partner child was ignorant about how to play, or (c) the apparatus broke. The subject child reacted differently in the three cases, protesting normatively against defection (with emotional arousal and later tattling), teaching when the partner seemed to be ignorant, or simply blaming the apparatus when it broke. These results suggest that 3‐year‐old children are competent in making appropriate normative evaluations of intentions and obligations of collaborative partners. 相似文献