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A Methylome‐Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder
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Edward D. Barker Esther Walton Charlotte A.M. Cecil Richard Rowe Sara R. Jaffee Barbara Maughan Thomas G. O'Connor Argyris Stringaris Alan J. Meehan Wendy McArdle Caroline L. Relton Tom R. Gaunt 《Child development》2018,89(5):1839-1855
In 671 mother–child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7–13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome‐wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong). 相似文献
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Jennifer Meehan 《Archival Science》2009,9(3-4):157-164
This article traces an alternative to the evidence/memory dichotomy in archival discourse by highlighting the nexus between archival ideas about the nature, value, and use of records as viewed and imagined through the lens of an archival concept of evidence as a relation between record and event. This article then explores how “the archival nexus” provides a different framework for understanding the various meaning-making processes surrounding archives both within and outside the archival repository, and for rethinking the role of the archivist and the position of the archival discipline with regard to other disciplines that explicitly address and engage with the archive. 相似文献
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Christopher Meehan 《Pastoral Care in Education》2002,20(1):16-24
This paper asserts that the spiritual is rooted in the essence of being human. Human beings search for meaning, purpose and direction in life and spiritual development is inextricably linked with this process. The spiritual manifests itself in the feelings and emotions of human beings, as well as the values, beliefs, aspirations and intellect. Spiritual development in this sense must be holistic. The spiritual dimension of education must engage the body, mind and heart. Spiritual development implies change, with a progression from immaturity towards maturity, from the simple to the complex, from the superficial to the profound. In relation to this the writer discusses what spiritual education should involve and the contribution different aspects of the curriculum can make. 相似文献
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Membership in civil rights and women's liberation organizations in the United States was tracked over a period of 22 years. Men's social and fraternal organizations were also tracked as a comparison group. Systematic fluctuations in membership suggest that this criterion would be useful for identifying the developmental stages of a movement. In addition, peaks in membership were correlated with historical events. Implications and directions for future research are discussed. 相似文献
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Measuring student experience in terms of satisfaction is a national measure used by prospective students when considering their higher education choices. Increasingly league tables are used as a means to rank universities with a limited interrogation of the reality of students’ experiences. This study explored the question ‘What really matters to freshers?’ during their transition into higher education through to completion. Students on an academic undergraduate Early Childhood Studies degree (n = 530) over a five-year period completed a Student Experience Evaluation in their first term and this data was correlated with the National Student Survey data collected about their cohorts in the final term of their degree. During the five year period, a number of interventions were undertaken by the academic staff to develop a learning community, based on the values linked to ‘being, belonging, and becoming’. The results of this study suggest that three things matter to students about their experience, that is, the academic staff they work with, the nature of their academic study and feeling like they belong. A model is proposed which aims to demonstrate the impact of academic staff, studies and the learning community that develops through social and academic experiences at University. 相似文献
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Emma Howard Maria Meehan Andrew Parnell 《Assessment & Evaluation in Higher Education》2019,44(1):97-110
In Maths for Business, a large first-year mathematics module, the continuous assessment component comprises 10 weekly quizzes which combine to contribute 40% of the final module mark. If students did not receive the full five marks on their weekly quiz, they were provided with the opportunity to resubmit their corrected weekly quiz with an explanation of their error(s) for one additional mark. We refer to this process as ‘remediation’. Of the students who had the opportunity to remediate, ~70% did. Through examining learning management system data, we show that the remediation process encouraged students to access module resources. Furthermore, by using a Bayesian hierarchical model to account for students’ level of participation, achievement and prior knowledge, we show that participation in the remediation process positively impacted the final examination marks of moderate to high-achieving students (based on initial continuous assessment marks). However, participation in the remediation process provided limited benefit to low-achieving students. We conjecture this is because these students had not achieved a level of understanding whereby participation in the remediation process could progress their knowledge. 相似文献
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This 2-year prospective investigation examined the association between the quality of teacher-student relationships and children's levels of aggression in a sample of 140 second- and third-grade aggressive children (M age = 8.18). Consistent with the proposed dual-risk compensatory hypothesis, positive teacher-student relationships were more beneficial for aggressive African American and Hispanic children than for aggressive Caucasian children. Data did not support a moderating effect of negative parent-child relationship quality on the association between supportive teacher-student relationships and aggression. Findings underscore the importance of recruiting and preparing teachers capable of establishing supportive relationships with aggressive African American and Hispanic children. Results also suggest the need for multiple reporters of relationship quality in future research. 相似文献
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Early Childhood Education Journal - In-person safety programs for pre-kindergarten children were not able to go on in their usual way during the summer of 2020 due to the Covid-19 pandemic. While... 相似文献