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To assess the influence of cyclosporin A (CsA) and tacrolimus (FK506) on mycophenolic acid (MPA) and correlation analysis
of the pharmacokinetic parameters and patient characteristics, clinical outcome in Chinese kidney transplant recipients, the
pharmacokinetics of 1000 mg mycophenolate mofetil (MMF) twice daily was measured by high-performance liquid chromatography
(HPLC). PKS (Pharmaceutical Kinctics Software) 1.0.2 software package was used for the calculation of pharmacokinetic parameters.
The meanC
max,t
max, and AUC(0–12) were (21.88±10.52) μg/ml, (1.20±0.95) h, and (52.546±13.215) μg·h/ml, respectively. The level of AUC(0–12) in the FK506 group was significantly higher than that in the CsA group. MPA appeared not to be affected by renal function.
MPA AUC(0–12) showed statistically significant difference according to the patient's gender.
Project (No. 20040462) supported by the Foundation of Education Bureau of Zhejiang Province, China 相似文献
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INTRODUCTION Mycophenolic acid (MPA) is the active me- tabolite of the registered prodrug mycophenolate mofetil (MMF) often used in combination with cyc- losporin A (CsA) or tacrolimus (FK506) as an im- munosuppressive agent after organ transplantation for the prophylaxis of acute rejection (Takahashi et al., 1995; Shaw et al., 1998). Following oral administra- tion, MMF is completely absorbed and rapidly hy- drolyzed to MPA by esterase present in the gut wall, liver, and possibly … 相似文献
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