Effect of antimalarials treatment on rat liver lysosomal function—Anin vivo study

Effects of treatmentin vivo with the antimalarials:chloroquine (CQ), primaquine (PQ) and quinine(Q) on lysosomal enzymes and lysosomal membrane integrity were examined. Treatment with the three antimalarials showed an apparent increase in the membrane stability. CQ treatment resulted in increase in both the ‘free’ and ‘total’ activities of all the enzymes i.e. acid phosphatase, RNase II, DNase II and cathepsin D. PQ treatment lowered the ‘free’ and ‘total’ activities of acid phosphatase and cathepsin D, but the DNase II activities increased. Treatment with Q resulted in increased ‘free’ and ‘total’ activities of RNase II and DNase II. While ‘free’ activities of acid phosphatase and cathepsin D were low; the ‘total’ activities increased significantly. Our results suggest that a generalized increase in free nucleases activities following prolonged treatment with antimalarials may lead to cell damage and/or necrosis.     

Magnetic fields and Bohr’s quantization rule

In this section of Resonance, we invite readers to pose questions likely to be raised in a classroom situation. We may suggest strategies for dealing with them, or invite responses, or both. “Classroom” is equally a forum for raising broader issues and sharing personal experiences and viewpoints on matters related to teaching and learning science.     

Correlation between serum lipid profile and carotid intima-media thickness in Polycystic Ovarian Syndrome

Abnormal lipid profile is often found in women with Polycystic Ovary Syndrome. To assess the impact of abnormal lipid profile on atherosclerosis in young Polycystic Ovary Syndrome women, carotid intima-media thickness as judged by B-mode ultrasonography were done in 30 young (18–35 yrs) Polycystic Ovary Syndrome women and in similarly age-matched 30 apparently healthy controls. Compared to controls, young Polycystic Ovary Syndrome women had significantly elevated serum total cholesterol, triglyceride and LDL-C levels and carotid intima-media thickness. HDL-C level did not differ significantly between two groups of women. In Polycystic Ovary Syndrome women carotid intima-media thickness was positively correlated with serum total cholesterol, triglyceride and LDL-C and negatively correlated with serum HDL-C. Our study suggests that even young Polycystic Ovary Syndrome women are prone to atherosclerosis from early age.     

Assessment of oxidative stress and effect of antioxidant supplementation during radiotherapy in carcinoma of upper digestive tract

Oxidative stress was studied by estimating plasma levels of malondialdehyde (MDA), beta carotene, vitamin E and erythrocytic superoxide dismutase(E-SOD) activity in 50 cases of carcinoma of upper digestive tract which included carcinoma of oral cavity, pharynx and oesophagus. While plasma MDA level was found to be increased (3.5±1.0 nmole/ml), a significant decrease in beta carotene (81.2±14.5mg%), vitamin E (8.5±1.1 mg/L) level and E-SOD activity (657.0±80.6 U/G Hb) were observed in carcinoma of upper digestive tract. Patients were treated with radiotherapy which itself was toxic enough and produced its deleterious effects by generation of reactive oxygen species (ROS). As antioxdiants can detoxify ROS, beneficial effect if any, of antioxidant administration during radiotherapy was studied in two groups of patients, group A (n=5, supplemented with antioxidants) and group B (n=5, without antioxidant supplementation). Plasma MDA level was found to be elevated in both the groups but the increase in group B was significant, compared to pretreatment level. Further, body weight was found to be significantly decreased in group B patients, which was maintained in group A patients. Moreover, group A patients showed significant elevation in beta carotene concentration, thus showing beneficial effect of administration of antioxidants during radiotherapy without disturbing the desirable therapeutic effect of radiotherapy.     

Predictors of student Internet use: data from three developing countries 1

Training, organizational support, attitude and national culture were explored in relation to college students’ Internet usage. Samples were drawn from India, Mauritius and Reunion Island (an overseas Department of France). Each nation differs culturally from the others. Questionnaire data was collected on students’ Internet usage as well as the predictor variables. Data was analyzed using hierarchical multiple regression. The country groups were dummy‐coded. Results suggested that attitude, training and university support were positively related to students’ Internet use. Non‐significant interaction terms suggested that these relationships did not change according to country sample. The present findings are consistent with previous reports using samples from Western, economically developed countries.     

Symmetries and conservation laws in classical and quantum mechanics 2. Quantum mechanics

In Part 1 of this two-part article we have spelt out, in some detail, the link between symmetries and conservation principles in the Lagrangian and Hamiltonian formulations of classical mechanics (CM). In this second part, we turn our attention to the corresponding question in quantum mechanics (QM). The generalization we embark upon will proceed in two directions: from the classical formulation to the quantum mechanical one, and from a single (infinitesimal) symmetry to a multi-dimensional Lie group of symmetries. Of course, we always have some definite physical system in mind. We also assume that the reader is familiar with the elements of quantum mechanics at the level of a standard first course on the subject. Operators will be denoted with an overhead caret, e.g., $ \hat A,\hat G,\hat U $ \hat A,\hat G,\hat U , etc., while $ [\hat A,\hat B] = \hat A\hat B - \hat B\hat A $ [\hat A,\hat B] = \hat A\hat B - \hat B\hat A is the commutator of $ \hat A $ \hat A and $ \hat B $ \hat B .     

Filaria associated clinical manifestations in children in an endemic area and morbidity control by immunomonitoring and optimal DEC therapy: Sevagram experience

Lymphatic filariasis is a major public health problem in India with 412 million people living in bancroftian endemic areas and is a major cause of clinical morbidity. Twenty million people are reported to suffer from chronic disease manifestations such as lymphoedema, hydrocele or elephantiasis. At least twice the number have been shown to suffer from acute and occult filarial infections in an endemic area without diagnosis. Due to non-availability of suitable diagnostic test for confirming filaria aetiology other than parasitological examination, no significant study on filariasis in children has been reported earlier. Studies in our laboratory for more than a decade showed usefulness of microfilarial excretory-secretory antigen in confirming filarial aetiology in acute and occult infections in adults as well as in children. This study reports acute and atypical manifestations such as lymphadenopathy, asthmatic bronchitis, pulmonary eosinophilia, mono-arthritis, recurrent URI, pneumonia, nutritional anemia, pain in abdomen etc. in children living in filaria endemic area having no microfilaraemia but showing filaria aetiology by immunomonitoring for the presence of antibody or antigen and responding to optimal DEC therapy.     

中印传统医药合作推进行动的政策建议

本文针对以西药为基础的发展中国家医疗保健高费用问题,提出建立"中印传统医药合作推进行动",借鉴健康影响基金的机制,通过中印两国在传统医药研究开发、质量控制、标准化、临床试验、监管体系、知识产权保护等方面的合作,探索面向低收入人群的、以传统医药为基础的医药创新、知识产权保护与医疗保健服务模式.     

Bayesian network based extreme learning machine for subjectivity detection

Subjectivity detection is a task of natural language processing that aims to remove ‘factual’ or ‘neutral’ content, i.e., objective text that does not contain any opinion, from online product reviews. Such a pre-processing step is crucial to increase the accuracy of sentiment analysis systems, as these are usually optimized for the binary classification task of distinguishing between positive and negative content. In this paper, we extend the extreme learning machine (ELM) paradigm to a novel framework that exploits the features of both Bayesian networks and fuzzy recurrent neural networks to perform subjectivity detection. In particular, Bayesian networks are used to build a network of connections among the hidden neurons of the conventional ELM configuration in order to capture dependencies in high-dimensional data. Next, a fuzzy recurrent neural network inherits the overall structure generated by the Bayesian networks to model temporal features in the predictor. Experimental results confirmed the ability of the proposed framework to deal with standard subjectivity detection problems and also proved its capacity to address portability across languages in translation tasks.