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Tadej Stegu 《British Journal of Religious Education》2015,37(1):53-63
The Catholic Church in Slovenia is facing the challenge of the new evangelisation in the area of religious education which, at present, is mainly confined to the parish catechesis. She recognises the urgent need to pass from the religious education of children to adult catechesis. The latter is already being implemented in various forms by a number of movements and new realities, which are mostly addressed to adults, indicating new catechetical approaches in a dechristianised environment. 相似文献
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Today’s software industry requires individuals who are proficient in as many programming languages as possible. Structured query language (SQL), as an adopted standard, is no exception, as it is the most widely used query language to retrieve and manipulate data. However, the process of learning SQL turns out to be challenging. The need for a computer-aided solution to help users learn SQL and improve their proficiency is vital. In this study, we present a new approach to help users conceptualize basic building blocks of the language faster and more efficiently. The adaptive design of the proposed approach aids users in learning SQL by supporting their own path to the solution and employing successful previous attempts, while not enforcing the ideal solution provided by the instructor. Furthermore, we perform an empirical evaluation with 93 participants and demonstrate that the employment of hints is successful, being especially beneficial for users with lower prior knowledge. 相似文献
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Convexity in a network (graph) has been recently defined as a property of each of its subgraphs to include all shortest paths between the nodes of that subgraph. It can be measured on the scale [0, 1] with 1 being assigned to fully convex networks. The largest convex component of a graph that emerges after the removal of the least number of edges is called a convex skeleton. It is basically a tree of cliques, which has been shown to have many interesting features. In this article the notions of convexity and convex skeletons in the context of scientific collaboration networks are discussed. More specifically, we analyze the co-authorship networks of Slovenian researchers in computer science, physics, sociology, mathematics, and economics and extract convex skeletons from them. We then compare these convex skeletons with the residual graphs (remainders) in terms of collaboration frequency distributions by various parameters such as the publication year and type, co-authors’ birth year, status, gender, discipline, etc. We also show the top-ranked scientists by four basic centrality measures as calculated on the original networks and their skeletons and conclude that convex skeletons may help detect influential scholars that are hardly identifiable in the original collaboration network. As their inherent feature, convex skeletons retain the properties of collaboration networks. These include high-level structural properties but also the fact that the same authors are highlighted by centrality measures. Moreover, the most important ties and thus the most important collaborations are retained in the skeletons. 相似文献
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Barbka Repic Lampret Simona Murko Marusa Debeljak Mojca Zerjav Tansek Petja Fister Tadej Battelino 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2015,25(2):279-284
Background
Short-chain acyl-CoA dehydrogenase deficiency (SCADD) is a rare inherited mitochondrial fatty acid oxidation disorder associated with variations in the ACADS (Acyl-CoA dehydrogenase, C-2 to C-3 short chain) gene. SCADD has highly variable biochemical, genetic and clinical characteristics. Phenotypes vary from fatal metabolic decompensation to asymptomatic individuals.Subject and methods
A Romani boy presented at 3 days after birth with hypoglycaemia, hypotonia and respiratory pauses with brief generalized seizures. Afterwards the failure to thrive and developmental delay were present. Organic acids analysis with gas chromatography-mass spectrometry (GS/MS) in urine and acylcarnitines analysis with liquid chromatography-tandem mass spectrometry (LC-MS/MS) in dried blood spot were measured. Deoxyribonucleic acid (DNA) was isolated from blood and polymerase chain reactions (PCRs) were performed for all exons. Sequence analysis of all exons and flanking intron sequences of ACADS gene was performed.Results
Organic acids analysis revealed increased concentration of ethylmalonic acid. Acylcarnitines analysis showed increase of butyrylcarnitine, C4-carnitine. C4-carnitine was 3.5 times above the reference range (<0.68 µmol/L). Confirmation analysis for organic acids and acylcarnitine profile was performed on the second independent sample and showed the same pattern of increased metabolites. Sequence analysis revealed 3-bp deletion at position 310-312 in homozygous state (c.310_312delGAG). Mutation was previously described as pathogenic in heterozygous state, while it is in homozygous state in our patient.Conclusions
In our case clinical features of a patient, biochemical parameters and genetic data were consistent and showed definitely SCAD deficiency.Key words: SCAD deficiency, short chain acyl-CoA dehydrogenase deficiency, screening, acylcarnitine, polymorphism, genetic 相似文献
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