Nobel prize 2010

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Nobel prize 2010     

Serum thyroglobulin antibody levels within or near to the reference range may interfere with thyroglobulin measurement

High concentration of thyroglobulin antibodies (TgAb) is a major limiting factor of thyroglobulin measurements in patients with differentiated thyroid cancer. We investigated whether thyroglobulin antibody added to serum samples could interfere with the thyroglobulin assay. Thyroglobulin levels in serum samples with different concentrations of thyroglobulin were measured by electrochemiluminescence immunoassay before and after the addition of increasing concentrations of thyroglobulin antibody using the secondary calibrator solution of the thyroglobulin assay kit containing sheep thyroglobulin antibody to reach thyroglobulin antibody levels within or near to the reference range. Thyroglobulin and thyroglobulin antibody concentrations were also measured in 134 serum samples from 27 patients after thyroid ablation. There was a strong negative association (slope = −1.179) between thyroglobulin antibody and thyroglobulin concentrations in samples with added thyroglobulin antibody (beta = −0.86; P < 0.001). Changes in thyroglobulin concentrations were described mathematically as loss of thyroglobulin% = −0.2408 × Ln(thyroglobulin antibody IU/ml) + 0.1944. Thyroglobulin concentrations were significantly lower than those calculated from experiments with added thyroglobulin antibody in 26/134 samples from patients after thyroid ablation. We conclude that if the same TgAb interference exists in the presence of naturally occurring human TgAb, our observation may prove to be useful during follow-up of patients with differentiated thyroid cancer. However, further studies are needed to explore the clinical relevance of thyroglobulin antibody levels within or near to the reference range in monitoring these patients.     

Longitudinal Trajectories,Social and Individual Antecedents,and Outcomes of Problematic Internet Use Among Late Adolescents

Given the detrimental effects associated with problematic internet use (PIU) and the need to better understand its nature and evolution, the present study examined the development of PIU in a sample of 1,750 adolescents (aged 16–19) from Finland over a 3-year period. We documented the social (loneliness, perceived maternal and paternal behaviors) and individual (sex) antecedents, as well as the outcome implications (depressive symptoms, substance use, academic achievement) of PIU trajectories. Outcomes also predicted PIU trajectories. Latent curve modeling revealed an initially moderate, and subsequently decreasing trajectory of PIU. PIU was predicted by loneliness, paternal neglect, maternal care, depressive symptoms, and being male. In turn, PIU trajectories predicted increases in depressive symptoms and substance use, but decreases in academic achievement.     

Investigating the Multidimensionality of Need Fulfillment: A Bifactor Exploratory Structural Equation Modeling Representation

This article assesses the multidimensionality of the Basic Psychological Need Satisfaction and Frustration Scale (BPNSFS) using bifactor exploratory structural equation modeling (bifactor ESEM). The first study relies on a sample of community adults (N = 2,301), and revealed the superiority of a bifactor ESEM representation, supporting the 6-factor structure of BPNSFS ratings, and the presence of a single continuum of need fulfillment relative to 2 distinct dimensions reflecting need satisfaction and frustration. These results were replicated in a second representative sample of the Hungarian adult population (N = 504), as well as across gender, and found no evidence of differential item functioning as a function of age. Relative to males, females presented higher levels of relatedness satisfaction and lower levels of competence satisfaction. Finally, autonomy frustration decreased with age, whereas competence satisfaction and frustration presented opposite curvilinear tendencies, showing that the fulfillment of this need increased sharply for younger participants, a tendency that became less pronounced with age.     

Does the repetitive use of the same test in consecutive examination sessions facilitate cheating?

This paper introduces an empirical study testing three kinds of bias in higher education student assessment. All of them are connected to the repetitive use of the same test questions which may facilitate academic cheating. The ‘same tests effect’ may appear if two or more groups of students are writing the same test one after the other and, as a result, a statistically significant improvement is detectable in the test scores of the second student group. The ‘revealed sameness effect’ is the impact of informing the students in some way that the test questions will be repeated. The ‘self selection effect’ arises when the students choose their examination turn themselves and this boosts their measured performance. The present study examines the three effects with independent t-tests and linear regression models on samples of 1221, 235, and 201 students (in this order), from four business courses in six academic semesters. The results do not support the ‘same test effect’, but support the ‘revealed sameness effect’ and the ‘self selection effect’.     

Induced beliefs about a fictive energy drink influences 200-m sprint performance†

Placebo and nocebo effects occur in response to subjective expectations and their subsequent neural actions. Research shows that information shapes expectations that, consequently, influence people’s behaviour. In this study, we examined the effects of a fictive and inert green colour energy drink provided for three groups (n?=?20/group) with different information. The first group was led to expect that the drink augments running performance (positive information), the second group was led to expect that the drink may or may not improve performance (partial-positive information), while the third group was told that earlier research could not demonstrate that the drink improves performance (neutral/control). At baseline, the three groups did not differ in their 200-m sprint performance (p?>?.05). One week later, 20-min immediately after ingesting the drink, all participants again ran 200?m. The positive information group increased its performance by 2.41?s, which was statistically significant (p?<?.001) and also perceived its sprint-time shorter (p?<?.05) than the other two groups. A better performance (0.97?s) that approached but did not reach statistical significance was also noted in the partial-positive information group, and a lesser change (0.72?s) that was statistically not significant was noted in the neutral information control group. These results reveal that drinking an inert liquid, primed with positive information, changes both the actual and the self-perceived time on a 200-m sprint. The current findings also suggest that the level of certainty of the information might be linked to the magnitude of change in performance.