Fluid balance and hydration assessment during the weight-stable preparation phase in elite youth boxers

This study investigated (i) the prevalence of hypohydration and (ii) association between urinary indices of hydration status and confounding factors (e.g., urine protein content, water intake) in elite youth boxers during their weight-stable phase before competition. Sixteen national champion boxers (all male, 17 ± 1 y) were measured on 3 occasions (baseline, day 3, day 10), 30-day prior to competition. Body mass, total body water, urine specific gravity (USG), osmolality (UOSM) and total protein content (TPC) were evaluated to determine hydration status and fluid balance. Overall macronutrient and water intake were assessed using dietary records. Both UOSM and USG increased from day 3 to day 10 by 16% and 0.4% (P < 0.001), despite athletes being in their weight-stability period, and regardless of ad libitum fluid intake. Hypohydration was universally prevalent among all athletes on both test days with USG: 1.027 ± 0.003 g · mL^?1 and UOSM: 1035 ± 108 mOsmol · kg^?1. An inverse association between mean UOSM values and mean water intake was observed (R = ?0.52, P = 0.04), while TPC was not associated with any urinary dehydration markers (USG, P = 0.51; UOSM, P = 0.61). The present outcomes find that the most prevalent urinary dehydration markers used to classify hydration status in competition exhibit large variability, even during weight-stable periods.     

The effects of short versus long inter-set rest intervals in resistance training on measures of muscle hypertrophy: A systematic review

Although the effects of short versus long inter-set rest intervals in resistance training on measures of muscle hypertrophy have been investigated in several studies, the findings are equivocal and the practical implications remain unclear. In an attempt to provide clarity on the topic, we performed a systematic literature search of PubMed/MEDLINE, Scopus, Web of Science, Cochrane Library, and Physiotherapy Evidence Database (PEDro) electronic databases. Six studies were found to have met the inclusion criteria: (a) an experimental trial published in an English-language peer-reviewed journal; (b) the study compared the use of short (≤60?s) to long (>60?s) inter-set rest intervals in a traditional dynamic resistance exercise using both concentric and eccentric muscle actions, with the only difference in resistance training among groups being the inter-set rest interval duration; (c) at least one method of measuring changes in muscle mass was used in the study; (d) the study lasted for a minimum of four weeks, employed a training frequency of ≥2 resistance training days per week, and (e) used human participants without known chronic disease or injury. Current evidence indicates that both short and long inter-set rest intervals may be useful when training for achieving gains in muscle hypertrophy. Novel findings involving trained participants using measures sensitive to detect changes in muscle hypertrophy suggest a possible advantage for the use of long rest intervals to elicit hypertrophic effects. However, due to the paucity of studies with similar designs, further research is needed to provide a clear differentiation between these two approaches.     

Reliability and discriminative ability of a modified Wingate rowing test in 12- to 18-year-old rowers

We evaluated (1) the test-retest reliability of the Wingate test conducted on a rowing ergometer, and (2) the sensitivity of this test in determining the differences in performance attained by 12- to 18-year-old rowers. Altogether, 297 male rowers aged 12.0-18.9 years (mean?±?s: 14.8?±?1.7) completed a maximal 30-s test on a rowing ergometer, and 80 rowers representing all age groups were retested after 5-7 days. No change was evident in participants' performance in terms of mean power output (P?=?0.726; Cohen's d?=?0.04), maximal power output (P?=?0.567; Cohen's d?=?0.06), and minimum power output (P?=?0.318; Cohen's d?=?0.11) in the second test. The intra-class correlation coefficients were high (≥0.973) and coefficients of variation were low (≤7.3%). A series of analyses of variance were used to compare the performances among 12- to 18-year-old rowers, and age-related increases in performance were evident (P?相似文献   

Reliability and discriminative ability of a modified Wingate rowing test in 12- to 18-year-old rowers

Abstract

We evaluated (1) the test–retest reliability of the Wingate test conducted on a rowing ergometer, and (2) the sensitivity of this test in determining the differences in performance attained by 12- to 18-year-old rowers. Altogether, 297 male rowers aged 12.0–18.9 years (mean ± s: 14.8 ± 1.7) completed a maximal 30-s test on a rowing ergometer, and 80 rowers representing all age groups were retested after 5–7 days. No change was evident in participants' performance in terms of mean power output (P = 0.726; Cohen's d = 0.04), maximal power output (P = 0.567; Cohen's d = 0.06), and minimum power output (P = 0.318; Cohen's d = 0.11) in the second test. The intra-class correlation coefficients were high (≥0.973) and coefficients of variation were low (≤7.3%). A series of analyses of variance were used to compare the performances among 12- to 18-year-old rowers, and age-related increases in performance were evident (P < 0.001; Cohen's d = 1.91–1.96). The age-related increases in performance were similar, although reduced, when the effects of body mass were partitioned out when using analysis of covariance (P < 0.001; Cohen's d = 0.82–0.85). The results suggest that: (1) the described test is reliable and can be used for maximal-intensity exercise assessment in youth rowing, and (2) it discriminates performance among 12- to-18-year-old rowers.     

Paraoxonase 1 activity and phenotype distribution in premenopausal and postmenopausal women

Introduction

Postmenopausal women have higher risk of cardiovascular disease. One of the contributing factors could be reduced activity of anti-atherogenic enzyme paraoxonase 1 (PON1). The aim of this study was to examine differences in the lipid status, paraoxonase and arylesterase PON1 activities and PON1 phenotype in women with regular menstrual cycle and in postmenopausal women.

Materials and methods:

The study included 51 women in reproductive age (25 in follicular and 26 in luteal phase of the menstrual cycle) and 23 women in postmenopause. Lipid parameters in sera were determined using original reagents and according to manufacturer protocol. PON1 activity in serum was assessed by spectrophotometric method with substrates: paraoxon and phenylacetate. PON1 phenotype was determined by double substrate method.

Results:

Compared to the women in follicular and luteal phase, postmenopausal women have significantly higher concentration of triglyceride [0.9 (0.7–1.3), 0.7 (0.6–1.0) vs. 1.5 (0.9–1.7) mmol/L; P = 0.002], cholesterol [5.10 (4.78–6.10), 5.05 (4.70–5.40) vs. 6.30 (5.73–7.23) mmol/L; P < 0.001], LDL [3.00 (2.56–3.63), 3.00 (2.70–3.70) vs. 3.90 (3.23–4.50) mmol/L; P < 0.001], and apolipoprotein B [0.88 (0.75–1.00), 0.79 (0.68–1.00) vs. 1.07 (0.90–1.24) mmol/L; P = 0.002]. PON1 basal [104 (66–260), 106 (63–250) vs. 93 (71–165) U/L; P = 0.847] and salt-stimulated paraoxonase activity [210 (131–462), 211 (120–442) vs. 180 (139–296) U/L; P = 0.857] as well as arylesterase activity [74 (63–82), 70 (54–91) vs. 70 (60–81) kU/L; P = 0.906] and PON1 phenotype (P = 0.810) were not different in the study groups.

Conclusion:

There are no differences in PON1 activity and PON1 phenotype between women with regular menstrual cycle and postmenopausal women.     

Different statistical measures create different perceptions of the digital divide

Simultaneous two-dimensional comparisons of time series data—vertically (static difference) and horizontally (Sicherl-time-distance)—for numerous ITU and Eurostat datasets show that estimates of the magnitude of digital divide can differ substantially between conventional static measures and Sicherl-time-distance, a dynamic measure of disparity. Comparing digital divide indicators with other indicators of social inequality (life expectancy, infant mortality), the analysis shows that high ICT growth rate improved well-being in developing countries and reduced some world inequalities. This methodology enables researchers, policy makers, and business managers how to draw new insights from existing data, including monitoring the attainment of targets.     

Use of biochemical parameters for non-invasive screening of oesophageal varices in comparison to elastography-based approach in patients with compensated advanced chronic liver disease

IntroductionOesophageal varices are routinely diagnosed by esophagogastroduodenoscopy (EGD), and their bleeding has high mortality. We aimed to evaluate diagnostic performance of biochemical tests in comparison to elastography-based approaches, as non-invasive alternatives to EGD, for ruling-out high risk oesophageal varices (HRV).Material and methodsRetrospective analysis of patients (N = 861) who underwent liver stiffness measurement (LSM) by transient elastography (TE) in a single centre over 5-year period, with available results of EGD (within 3 months from LSM). Only patients with suspicion of compensated advanced chronic liver disease (cACLD) defined by LSM ≥ 10 kPa were included comprising the final cohort of 73 subjects. Original and expanded Baveno VI criteria (B6C), controlled attenuation parameter (CAP), platelet count (PLT), aspartate aminotransferase to PLT ratio index (APRI), Fibrosis-4 index (FIB4), model for end stage liver disease (MELD) score were evaluated against the results of EGD that served as the reference method.ResultsAnalysed patients had median age 62 years, 59/73 (0.81) were males, 54/73 (0.74) had alcoholic/non-alcoholic fatty liver disease, and 21/73 (0.29) had HRV. In multivariate logistic regression analysis only LSM and PLT were independently associated with HRV. The best performing tests for ruling-out HRV (% of spared EGD; % of missed HRV) were respectively: LSM < 20 kPa (53.4%; 0%), B6C (38%; 0%), Expanded B6C (47.9%; 4.8%); PLT > 214x10⁹/L (21.9%; 0%); FIB4 ≤ 1.8 (21.4%; 0%), APRI ≤ 0.34 (12.3%; 0%). CAP, MELD = 6 alone or combined with PLT > 150(x10⁹/L) did not show acceptable performance.ConclusionThe best performing biochemical tests for ruling-out HRV in our cohort of patients were PLT and FIB-4, but they were still outperformed by elastography-based approaches.Keyword: portal hypertension, cirrhosis, platelet count, esophageal varices, non-invasive tests     

Methodological Challenges of Digital Divide Measurements

The term “digital divide” has been used for almost a decade and typically relates to sociodemographic differences in the use of information and communication technology. However, the corresponding measurement is still relatively imprecise. Very often it is simply reduced to comparisons of Internet penetration rates. This article extends the measurements above the usual bivariate comparisons. Within this context, three essential approaches are presented and critically evaluated. First, loglinear modeling is used to address the interactions among the factors affecting the digital divide. Second, compound measures (i.e., the Digital Divide Index) that integrate a number of variables into a single indicator are discussed. Third, time-distance methodology is applied to analyze changes in the digital divide. The article argues that these approaches often yield entirely different conclusions compared to simple bivariate analysis. The examples are presented as a general warning against an oversimplified methodological approach to digital divide studies.